Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf &amp; Leechman and underlying mechanisms

Barbosa, Jéssica Andréia Pereira; Santana, Marllon Alex Nascimento; Leite, Tonny Cley Campos; Oliveira, Tatiane Bezerra de; Mota, Fernanda Virgínia Barreto; Bastos, Isla Vanessa Gomes Alves; Corrêa, Allan Jonathan Chernichiarro; Amorim, Elba Lúcia Cavalcanti de; Vieira, Jeymesson Raphael Cardoso; Silva, Tânia Maria Sarmento; Santana, Andréa Lopes Bandeira Delmiro; Nascimento, Márcia Silva do; Silva, Teresinha Gonçalves da

doi:10.1016/j.biopha.2019.01.043

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…Instead, MDA is a product of lipid peroxidation, which indirectly reflects the ability of metabolism to scavenge free radicals. These indices are commonly used to measure oxidative damage in the body [ 37 – 39 ]. PGE2 is considered a gastric protective factor by regulating gastric pH, mucus secretion and maintaining the integrity of gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Wang

Zhang

et al. 2021

BioMed Research International

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Background. Magnolia officinalis Rehd. and Wils. is widely used in Asian countries because of its multiple pharmacological effects. This study investigated the gastroprotective effect and mechanisms of the ethanol extracts from the bark of Magnolia officinalis (MOE) against ethanol-induced gastric mucosal damage in rats. Methods. MOE was prepared by reflux extraction with 70% ethanol, and its main compounds were analyzed by UPLC-Q-Exactive Orbitrap-MS. DPPH, ABTS, and FRAP methods were used to evaluate the antioxidant capacity of MOE in vitro. The gastroprotective effects of MOE were evaluated by the area of gastric injury, H&E (hematoxylin-eosin), and PAS (periodic acid-Schiff). The mechanism was explored by measuring the levels of cytokines and protein in the NF-κB signaling pathway. Results. 30 compounds were identified from MOE, mainly including lignans and alkaloids. MOE presented a high antioxidant activity in several oxidant in vitro systems. Gastric ulcer index and histological examination showed that MOE reduced ethanol-induced gastric mucosal injury in a dose-dependent manner. MOE pretreatment significantly restored the depleted activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzymes, reduced malondialdehyde (MDA), and prostaglandin E2 (PGE2) levels in the gastric tissue in rats. In addition, MOE also inhibited the activation of nuclear factor kappa B (NF-κB) pathway and decreased the production of proinflammatory cytokines. Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.

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Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Wang

Zhang

et al. 2021

BioMed Research International

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“…These findings augment previous reports on the gastroprotective effect of Avicennia sp. leaves [28]. At the neurological level, alcoholic leaf extract of A. marina has a mild effect on the locomotory activity of SW mice, either diabetic or not.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice

Okla

Alamri

Alatar

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals. Streptozotocin-induced diabetes is considered an autoimmune disease. The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes. The animals were divided into four groups: a control group (A), an A. marina receiving nondiabetic group (B), a diabetic group (C), and a DM group orally supplemented with A. marina alcoholic leaf extract (D). The DM group of animals receiving the alcoholic extract of A. marina leaves had reduced blood glucose levels, improved blood picture, and organ functions. This group also showed improvement in locomotory behavior. The results of this study showed that supplementation with the alcoholic extract of A. marina leaves reduced oxidative stress and blood sugar levels, protected the liver, and improved the neurobehavioral changes associated with diabetes in mice. Introducing alcoholic leaf extract of A. marina to diabetic mice decreased inflammatory cells aggregation, vacuolation, and hemorrhage. Additionally, a positive effect of the alcoholic leaf extract on the histopathological changes was observed in the testicular tissue of treated mice.

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Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Hossen

Reza

Ahmed

et al. 2021

Biomedicine & Pharmacotherapy

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Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms

Cited by 8 publications

References 46 publications

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats

Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice

Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

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