Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats

Abstract

Polygonum cuspidatum is widely used as food and medicine in Korea, China, and Japan. Its major bioactive components, resveratrol and emodin, reportedly protect against gastric lesions. We therefore aimed to investigate: (1) the gastroprotective effects of P. cuspidatum roots in hydrochloric acid/ethanol (HCl/EtOH)- and indomethacin-induced acute gastric ulcer rat models; (2) the healing effects in an acetic acid-induced ulcer model; and (3) potential mechanisms by measuring gastric acid secretion-related parameters in a pyloric ligation-induced ulcer model, and by measuring antioxidant enzyme and prostaglandin E2 levels in the gastric tissue of HCl/EtOH-treated rats. Oral administration of P. cuspidatum extract (PCE) at doses of 100 and 300 mg/kg significantly decreased HCl/EtOH- and indomethacin-induced gastric lesions. PCE at 300 mg/kg significantly reduced gastric lesions in acetic acid-induced ulcers. PCE increased superoxide dismutase (SOD) activity and glutathione (GSH) and prostaglandin E2 levels in gastric tissue, whereas it did not alter gastric acid secretion-related parameters. Our findings indicate that PCE has gastroprotective effects against HCl/EtOH and non-steroidal anti-inflammatory drugs (NSAIDs) and promotes healing of acetic acid-induced ulcers. These gastric mucosal protection and ulcer healing effects are associated with antioxidant effects and the augmentation of prostaglandin E2 and suggest that P. cuspidatum might be a promising preventive and therapeutic agent for treating gastric ulcers.

Therapeutic strategies of Moringa oleifera Lam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model

“…Our findings are consistent with the data obtained by Ganesan et al (2010) indicated that HCl/EtOH reduce the levels of GSH dependent antioxidant enzymes (GPx and GST), GSH and antiperoxidative enzymes, such as SOD and CAT in ulcerated rats. Recently, the work done by Kim et al (2020) , demonstrated that the GSH levels and SOD activities were markedly elevated in the stomach tissues of HCl/EtOH-ulcerated rats. Further, it was observed that in acidified EtOH- administered rats there was increased ROS generation assessed by increased level of TBARS and attenuated levels of CAT, SOD, GSH and GPx activities and GST along with decreased mucus secretion ( Guesmi et al, 2014 ).…”

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

“…However, Phy-Blica-D treatment did not affect the gastric pH. Normally, acid secretion is suppressed by standard drugs, such as OMZ, through proton-pump inhibition [ 9 ]. Therefore, we concluded that gastric acid inhibition is unlikely to be a mechanism underlying the beneficial effects of Phy-Blica-D.…”

“…Several modern drugs, such as antacids, antibiotics, H2 receptor antagonists, and proton-pump inhibitors (PPIs), are widely used for the treatment of gastritis [ 7 ]. Omeprazole (OMZ), a PPI, has been reported to exert a gastroprotective effect in numerous published studies [ 7 , 8 , 9 , 10 , 11 ]. However, long-term treatment with modern drugs can cause adverse effects [ 12 ].…”

Essential Oils Derived from Momordica charantia Seeds Exhibited Antiulcer Activity against Hydrogen Chloride/Ethanol and Indomethacin

“…The experiment was performed based on a slight modification of the method described by Mizui and Doteuchi [ 22 ]. Briefly, experimental animals were fasted for 24 hours with free access to water.…”