Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

“…However, no studies thus far have reported on the in vitro cytotoxic activity of this natural compound for normal liver cells to demonstrate its ability to prevent acute tissue damage (12). The low toxicity of arbutin is in accordance with previous in vitro studies on human melanocytes that were exposed to arbutin (31).…”

“…This plant has a variety of pharmacological and therapeutic properties, including anti-inflammatory, antiviral, anti-hyperglycemic, anti-hyperlipidemic, and antioxidant activity (10). It has been shown to scavenge free radicals (11), be gastroprotective (12), and exhibit alpha-glycosidase and alpha-amylase inhibitory activity (13). Previous studies have revealed that plants containing polyphenols demonstrate clear anti-hepatotoxic properties (14).…”

Antioxidant and anti-inflammatory activities contribute to the prophylactic effect of semi-purified fractions obtained from the crude methanol extract of Muntingia calabura leaves against gastric ulceration in rats

“…Ethanol effectively reduces the flow of gastric blood and level of NO in gastric mucosa, causing the development of hemorrhagic necrosis. This subsequently leads to the solubilization of gastric mucus constituents, resulting in increased pepsin secretion and flow of Na þ and K þ ions, while causing loss of H þ ions and histamine into the lumen (Taha et al, 2012). Szabo (1987) has reported that ethanol damage to the gastrointestinal mucosa begins with microvascular injury, including epithelial lifting, edema formation and disruption of the vascular endothelium that causes an increase in vascular permeability.…”

Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats

“…It is suggested that the pro-inflammatory cytokines TNF-a and IL-6 are important in regulating the severity of gastric ulcers, which can enhance the effects of oxidative stress by inducing mitochondrial ROS generation and cytotoxicity [33,34]. IL-10 is one of the most important antiinflammatory cytokines and could suppress the inflammatory response.…”