Gastrointestinal transport of calcium and phosphate in lactating goats

Starke, S.; Reimers, J. H. W. Th.; Muscher-Banse, Alexandra S.; Schröder, Bernd; Breves, Gerhard; Wilkens, Mirja R.

doi:10.1016/j.livsci.2016.04.023

Cited by 4 publications

(8 citation statements)

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“…In lactating goats, P i flux rates from the mucosal to the serosal side of the epithelium, determined in the duodenum and jejunum, were significantly smaller in comparison to dried-off animals, resulting in a reduced net absorption (Figure 8). This was accompanied by a downregulation of jejunal NaP i IIb, both on RNA and protein levels, probably as a consequence of either higher P intake or enhanced mobilisation of P i from the skeleton (Starke et al, 2016). In line with other studies, NaP i IIb was not detectable in the duodenum (Huber et al, 2002).…”

Section: Sites and Mechanisms Of Gastrointestinal Phosphorus Absorptionsupporting

confidence: 86%

“…Taken together with results from lactating and dried-off sheep and goats, it might be concluded that the responsiveness of intestinal Ca absorption to enhanced demand or restricted supply varies between different species and ages (Wilkens et al, 2014;Klinger et al, 2016;Starke et al, 2016). In lactating and non-lactating cows, balance studies demonstrated that Ca digestibility is not increased with dietary Ca restriction, although lactation itself seems to enhance gastrointestinal absorption (Table 1).…”

Section: Transcellular Intestinal Calcium Absorptionmentioning

confidence: 89%

“…As also shown in Table 1, these findings show that rumen Ca transport depends on luminal abundance of different factors and nutrients. Therefore, greater Ca flux rates determined for rumen tissue of lactating goats in comparison to dried-off animals (2.28 ± 0.35 v. 6.75 ± 1.16 nmol/cm 2 •h) could be either a direct effect of lactation or be caused by the different feeding regime and/or an enlargement of the luminal surface (Starke et al, 2016). In cows, rumen Ca transport estimated by the administration of stable strontium is stimulated by lactation and decreased when forestomach motility is reduced (Hyde et al, 2019).…”

Section: Transcellular Pre-intestinal Calcium Absorptionmentioning

confidence: 91%

“…Means ± SEM; *, P < 0.05. Modified from Starke et al (2016). small ruminants (sheep: 0.83 ± 0.22 v. 1.06 ± 0.24%, goats: 0.71 ± 0.13 v. 1.03 ± 0.21%).…”

Section: Renal Handling Of Calciummentioning

confidence: 99%

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Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants

Wilkens¹,

Muscher-Banse²

2020

Animal

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In comparison to monogastric animals, ruminants show some peculiarities in respect to the regulation of mineral homeostasis, which can be regarded as a concerted interplay between gastrointestinal absorption, renal excretion and bone mobilisation to maintain physiological Ca and phosphate (Pi) concentrations in serum. Intestinal absorption of Ca or Pi is mediated by two general mechanisms: paracellular, passive transport dominates when luminal Ca or Pi concentrations are high and transcellular. The contribution of active transport becomes more important when dietary Ca or Pi supply is restricted or the demand increased. Both pathways are modulated directly by dietary interventions, influenced by age and regulated by endocrine factors such as 1,25-dihydroxyvitamin D3. Similar transport processes are observed in the kidney. After filtration, Ca and Pi are resorbed along the nephron. However, as urinary Ca and Pi excretion is very low in ruminants, the regulation of these renal pathways differs from that described for monogastric species, too. Furthermore, salivary secretion, as part of endogenous Pi recycling, and bone mobilisation participate in the maintenance of Ca and Pi homeostasis in ruminants. Saliva contains large amounts of Pi for buffering rumen pH and to ensure optimal conditions for the rumen microbiome. The skeleton is a major reservoir of Ca and Pi to compensate for discrepancies between demand and uptake. But alterations of the regulation of mineral homeostasis induced by other dietary factors such as a low protein diet were observed in growing ruminants. In addition, metabolic changes, for example, at the onset of lactation have pronounced effects on gastrointestinal mineral transport processes in some ruminant species. As disturbances of mineral homeostasis do not only increase the risk of the animals to develop other diseases, but are also associated with protein and energy metabolism, further research is needed to improve our knowledge of its complex regulation.

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Section: Sites and Mechanisms Of Gastrointestinal Phosphorus Absorptionsupporting

confidence: 86%

Section: Transcellular Intestinal Calcium Absorptionmentioning

confidence: 89%

Section: Transcellular Pre-intestinal Calcium Absorptionmentioning

confidence: 91%

“…Means ± SEM; *, P < 0.05. Modified from Starke et al (2016). small ruminants (sheep: 0.83 ± 0.22 v. 1.06 ± 0.24%, goats: 0.71 ± 0.13 v. 1.03 ± 0.21%).…”

Section: Renal Handling Of Calciummentioning

confidence: 99%

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Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants

Wilkens¹,

Muscher-Banse²

2020

Animal

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“…In the present study, the duodenal P i flux rates were relatively low compared to the jejunum [ 62 ] and ileum and were in a similar range to duodenal P i transport from previous experiments with goats [ 3 , 4 ], indicating that the duodenum is of minor importance for intestinal P i absorption. The applied feeding regime had no effect on P i transport in the duodenum.…”

Section: Discussionsupporting

confidence: 80%

Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet

Behrens¹,

Schnepel²,

Hansen³

et al. 2021

IJMS

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The intestinal absorption of phosphate (Pi) takes place transcellularly through the active NaPi-cotransporters type IIb (NaPiIIb) and III (PiT1 and PiT2) and paracellularly by diffusion through tight junction (TJ) proteins. The localisation along the intestines and the regulation of Pi absorption differ between species and are not fully understood. It is known that 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3) and phosphorus (P) depletion modulate intestinal Pi absorption in vertebrates in different ways. In addition to the apical uptake into the enterocytes, there are uncertainties regarding the basolateral excretion of Pi. Functional ex vivo experiments in Ussing chambers and molecular studies of small intestinal epithelia were carried out on P-deficient goats in order to elucidate the transepithelial Pi route in the intestine as well as the underlying mechanisms of its regulation and the proteins, which may be involved. The dietary P reduction had no effect on the duodenal and ileal Pi transport rate in growing goats. The ileal PiT1 and PiT2 mRNA expressions increased significantly, while the ileal PiT1 protein expression, the mid jejunal claudin-2 mRNA expression and the serum 1,25-(OH)2D3 levels were significantly reduced. These results advance the state of knowledge concerning the complex mechanisms of the Pi homeostasis in vertebrates.

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Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology

Muscher-Banse

Breves

2018

Pflugers Arch - Eur J Physiol

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Ruminants have a unique utilization of phosphate (P) based on the so-called endogenous P recycling to guarantee adequate P supply for ruminal microbial growth and for buffering short-chain fatty acids. Large amounts of P enter the gastrointestinal tract by salivary secretion. The high saliva P concentrations are generated by active secretion of P from blood into primary saliva via basolateral sodium (Na)-dependent P transporter type II. The following subsequent intestinal absorption of P is mainly carried out in the jejunum by the apical located secondary active Na-dependent P transporters NaPi IIb (SLC34A2) and PiT1 (SLC20A1). A reduction in dietary P intake stimulates the intestinal P absorption by increasing the expression of NaPi IIb despite unchanged plasma 1,25-dihydroxyvitamin D concentrations, which modulate P homeostasis in monogastric species. Reabsorption of glomerular filtrated plasma P is mainly mediated by the P transporters NaPi IIa (SLC34A1) and NaPi IIc (SLC34A3) in proximal tubule apical cells. The expression of NaPi IIa and the corresponding renal Na-dependent P capacity were modulated by high dietary phosphorus (P) intake in a parathyroid-dependent manner. In response to reduced dietary P intake, the expression of NaPi IIa was not adapted indicating that renal P reabsorption in ruminants runs at a high level allowing no further increase when P intake is diminished. In bones and in the mammary glands, Na-dependent P transporters are able to contribute to maintaining P homeostasis. Overall, the regulation of P transporter activity and expression by hormonal modulators confirms substantial differences between ruminant and non-ruminant species.

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Gastrointestinal transport of calcium and phosphate in lactating goats

Cited by 4 publications

References 50 publications

Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants

Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants

Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet

Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology

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