Gastrointestinal stromal tumor of the anal canal: an unusual presentation

Nigri, Giuseppe; Dente, Mario; Valabrega, Stefano; Aurello, Paolo; D’Angelo, Francesco; Montrone, Giuseppe; Ercolani, Giorgio; Ramacciato, Giovanni

doi:10.1186/1477-7819-5-20

Cited by 29 publications

(23 citation statements)

References 22 publications

(21 reference statements)

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“…La protéine c-kit est un récepteur transmembranaire dont le ligand est un facteur de croissance. Dans les cellules exprimant le gène c-kit muté, l'activation non régulée de la protéine est à l'origine d'une prolifération cellulaire incontrôlable aboutissant à l'apparition d'une tumeur [1,[6][7][8].…”

Section: Discussionunclassified

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Tumeur stromale anorectale: à propos d’une localisation rare des GIST

et al. 2010

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Les tumeurs stromales du tube digestif ou GIST sont des tumeurs indifférenciées rares : 1-3 % des tumeurs malignes gastro-intestinales. La localisation anorectale est très rare. Du fait d'un potentiel de récidive très important, les tumeurs stromales de haut grade de malignité doivent bénéficier d'une chirurgie agressive encadrée d'une chimiothérapie néoadjuvante ou adjuvante pour améliorer la résé-cabilité et diminuer le risque de récidive. Nous rapportons une observation de tumeur stromale anorectale et nous en discutons les particularités diagnostique, thérapeutique et pronostique à la lumière des données de la littérature. Mots clés Anorectale · Stromale · Tumeur · Chirurgie · ImatinibAbstract Gastrointestinal stromal tumours (GIST) are uncommon, undifferentiated lesions, representing 1-3% of gastrointestinal malignancy. Localisation in the anorectal area is very rare. The chances of recurrence are substantial, so high-grade stromal tumours require aggressive surgery accompanied by neoadjuvant or adjuvant chemotherapy, so as to improve resectability and reduce the risk of relapse. We report a case of anorectal stromal tumour and discuss the diagnostic, therapeutic and prognostic features in the light of information available in the literature.

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Section: Discussionunclassified

“…Les autres localisations, notamment anorectales, sont rares, représentant 5 % environ de l'ensemble des localisations [1,6].…”

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Tumeur stromale anorectale: à propos d’une localisation rare des GIST

et al. 2010

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“…They arise from the interstitial cells of Cajal and they account for 0.1 % to 3 % of all G.I malignancies [2]. The site distribution of these tumours is as follows: Esophagus (3 %-5 %),stomach(60 %), small intestine(25 %-30 %), colon and rectum(1 %-5 %),others(2 %-6 %)- [1][2][3]. Gastrointestinal stromal tumors of the small intestine presenting with perforation can be found as isolated reports [5,8].…”

Section: Discussionmentioning

confidence: 99%

“…They commonly originate in the stomach, followed by small intestine [1][2][3][4]. They rarely arise in the caecum, with the entire colon and rectum contributing to less than 5 % of all GISTs [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Caecal Gastrointestinal Stromal Tumor with Perforation and Obstruction

Sreevathsa

2012

Indian J Surg Oncol

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“…It has recently been suggested that ICC or their precursor matrix mesenchymal cell may be the origin of the stroma tumors. Therefore, GIST are sometimes called the gastrointestinal pacemaker cell tumors (GIPACT) (4,5,(14)(15)(16)(17).…”

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Influence of Location and Mitotic Index on Prognosis in Patients with Gastrointestinal Stromal Tumors

Mrowiec¹,

Jabłońska²,

Leidgens³

et al. 2008

Polish Journal of Surgery

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Gastrointestinal stroma tumors (GIST) arise from the pacemaker, the interstitial Wells of Cajal. These tumors constitute 1 to 3% of gastrointestinal neoplasms, and may occur in each portion of the gastrointestinal tract. The most useful prognostic factors are tumor size, mitotic index, cell structure and location within the gastrointestinal tract. The aim of the study was to assess the chosen prognostic factors (location in the gastrointestinal tract and mitotic index) in patients with GIST. Material and methods. Between 1989 and 2002, 74 patients (37 men and 37 women) with an average age of 54.9 years (range from 13 to 89 years) were operated for GIST in the Department of Gastrointestinal Surgery. Two-and five-year survival rates during observation were analyzed, as well as the location within the gastrointestinal tract and mitotic index. Based on the intraoperative and postoperative investigations, the tumor size, presence of metastases and histological type of predominant cells were estimated in each patent. Results were subjected to statistics, where p£0.05 was considered to be significant. Results. Of the 74 patients included in the study, 3 patients (4%) had a primary tumor located in the lower oesophagus, 42 patients (56.8%) in the stomach, 4 patients (5.4%) in the duodenum, and 13 patients (17.6%) had tumors originated from the small intestine. In an additional 12 patients (16.2%), the tumor originated from the large intestine. The most frequent (51%) mitotic index was 2, and 9/50 hpf was considered an intermediate malignant potential risk. Two-year survival was common in patients with GIST located in the oesophagus, stomach, and duodenum, totalling 34 (79%) patients. A lower than two-year survival rate was noted in patients with GIST arising from the small intestine: 7 (63.6%) patients had tumors arising from the colon and 4 (36.3%) patients had rectal tumors. Five-year survival was also the most frequent in patients with GIST located in the upper part of gastrointestinal tract (37.2%), in the median part of gastrointestinal tract (36.3%), and in the lower part of the gastrointestinal tract (27.7%). Correlation between location, mitotic index and survival of patients was assessed. The correlation studies showed a statistically significant influence of tumor location in the gastrointestinal tract (p=0.0264) and mitotic index (p=0.0003) with the survival of patients operated for GIST. Thus, the lower location and higher mitotic index of GIST are associated with shorter survival of patients. Conclusions. The mitotic index and location in the gastrointestinal tract are essential prognostic factors in analyzed patients with GIST. In the analyzed group, the lower locations and higher mitotic indices of GIST were associated with shorter survival of patients.

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Gastrointestinal stromal tumor of the anal canal: an unusual presentation

Cited by 29 publications

References 22 publications

Tumeur stromale anorectale: à propos d’une localisation rare des GIST

Tumeur stromale anorectale: à propos d’une localisation rare des GIST

Caecal Gastrointestinal Stromal Tumor with Perforation and Obstruction

Influence of Location and Mitotic Index on Prognosis in Patients with Gastrointestinal Stromal Tumors

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