Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage

Kim, Kyu-Jong; Moon, Won; Park, Moo In; Park, Seun Ja; Lee, Seung Hyun; Chun, Bong Kwon

doi:10.3748/wjg.v13.i23.3265

Cited by 22 publications

(14 citation statements)

References 19 publications

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“…GISTs of the vermiform appendix constitute only 0.1% of all GISTs (1), with only 16 cases reported in the English literature to date (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The characteristics of these 17 GIST cases (including the present case) are listed in Table I.…”

Section: Discussionmentioning

confidence: 87%

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Kaneko

Kawai

Murono

et al. 2017

Molecular and Clinical Oncology

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Abstract.Gastrointestinal stromal tumors (GISTs) of the vermiform appendix are rare, measuring <3 cm in 82.4% of the reported cases. Neoadjuvant therapy with the receptor tyrosine kinase inhibitor imatinib mesylate has the potential to improve resectability and organ preservation rates in locally advanced or metastatic/recurrent GISTs. We herein report the case of a 67-year-old male patient with an unusually large GIST (22 cm in diameter) of uncertain origin in the right lower abdominal quadrant, with a solitary peritoneal metastasis. Due to the size of this GIST and presence of metastatic disease, neoadjuvant therapy with imatinib (400 mg/day orally) was administered. Follow-up imaging studies revealed marked shrinkage of the primary and metastatic tumors. Subsequently, laparoscopic exploration revealed that the main tumor originated from the tip of the vermiform appendix, and that the peritoneal metastasis was located in the ascending mesocolon. The patient underwent laparoscopic appendectomy and excision of the peritoneal metastasis, without tumor rupture. Therefore, in appropriately selected patients, neoadjuvant imatinib for borderline resectable or oligometastatic GISTs may be a reasonable choice.

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Section: Discussionmentioning

confidence: 87%

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Kaneko

Kawai

Murono

et al. 2017

Molecular and Clinical Oncology

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“…Appendiceal GISTs are extremely rare making up approximately 0.1% of all cases [7], with less than ten cases reported in the literature thus far, all of which were benign and measuring less that 3 cm in diameter. Reported presentations include appendicitis-like symptoms, incidental finding during unrelated work-up [8,9], and spontaneous hemorrhage [10].…”

Section: Discussionmentioning

confidence: 99%

Malignant Appendiceal GIST: Case Report and Review of the Literature

Elazary

Schlager

Khalaileh

et al. 2009

J Gastrointest Canc

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“…Surprisingly, there are also at least 3 case reports of aorto‐appendiceal fistulas as a cause of LGIB 13–15. Less common causes include medication‐induced ulcers,16 tumors,17 endometriosis,18 mucoceles,19 and intussusception 20…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of lower gastrointestinal bleeding

et al. 2008

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Objective Clinical magnetic resonance studies show delayed and ongoing neurodegeneration after neonatal hypoxia‐ischemia (HI), but the mechanisms and timing of this neurodegeneration remain unclear. We used ex vivo diffusion tensor imaging (DTI) and brain neuropathology to determine whether selective injury to white matter tracts occurs after neonatal HI in mice resulting in neural system–associated attrition in remote regions and at delayed times. Methods The Rice–Vannucci model (unilateral carotid ligation + 45 minutes of hypoxia FiO2 = 0.08) was used to cause brain injury in postnatal day 7 (p7) C57BL6 mice, and ex vivo DTI and correlative neuropathology were performed at p8, p11, p15, p21, p28, and p42. Results DTI provides excellent contrast visualization of unmyelinated white matter in the immature mouse brain. Severe ipsilateral injury to the hippocampus is seen with both histopathology and diffusion‐weighted magnetic resonance imaging 24 hours after injury. Injury to axons is evident 24 hours after HI in the hippocampal alveus. By p11 and continuing until p28, the ipsilateral fimbria fornix degenerates. At p15, there is injury and loss of axons entering the ipsilateral septal nucleus followed by ipsilateral septal atrophy. Volume loss in the hippocampus is rapid and severe, but is subacute and significantly slower in the ipsilateral septum. Neonatal HI also interrupts the normal developmental increase in fractional anisotropy in the ipsilateral fimbria but not in the contralateral fimbria from p8 to p42. Interpretation In neonatal brain, there is progressive systems‐preferential injury after HI. DTI allows unparalleled visualization of this neural network–associated attrition so that it can be followed longitudinally in developing brain. Ann Neurol 2008;64:535–546

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Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage

Cited by 22 publications

References 19 publications

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Malignant Appendiceal GIST: Case Report and Review of the Literature

An unusual cause of lower gastrointestinal bleeding

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