Gastrointestinal satiety signals

Chaudhri, Owais B.; Field, Benjamin; Bloom, Stephen R.

doi:10.1038/ijo.2008.235

Cited by 46 publications

(24 citation statements)

References 38 publications

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“…Several mechanisms could have been responsible for these differences. Enhanced satiety and reduced hunger immediately after HENSD supplementation can be attributed to significantly higher plasma concentrations of PYY and CCK, which are known to elicit anorexigenic effects (Chaudhri, Field, & Bloom, 2008;Suzuki, Simpson, Minnion, Shillito, & Bloom, 2010) and to insulin, which plays a role in appetite regulation of lean individuals (A. Flint et al, 2007).…”

Section: Hensd Placebomentioning

confidence: 99%

Response of appetite and potential appetite regulators following intake of high energy nutritional supplements

et al. 2015

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Keywords:High energy supplements Appetite Appetite hormones Gastric emptying Thermogenesis Control of food intake a b s t r a c t Background:The net clinical benefit of high-energy nutritional supplements (HENSDs) consumption is lower than expected. Objectives: To investigate the extent to which consumption of oral HENSD in the fasted state reduces energy intake in slim females during consecutive breakfast and lunch, and whether this relates to changes in appetite and metabolic appetite regulators. Design: Twenty three females of 24.4 ± 2.8 years with BMI of 18.2 ± 0.8 kg/m 2 consumed HENSD (2.5 MJ) or PLACEBO (0.4 MJ) in fasted state in a single blind randomized cross-over study. Appetite and metabolic rate measurements and blood collection were conducted prior to and during 240 min after the intake of the supplements. Energy intake was recorded during ad libitum buffet breakfast and lunch served 60 min and 240 min post supplementation respectively. Results: Energy intake during breakfast was significantly (P < 0.01) lower in the HENSD trial but the net cumulative effect on energy intake was 1.07 ± 0.34 MJ higher in the HENSD compared to PLACEBO. Plasma concentration of CCK and PYY and insulin and were significantly (P < 0.05) higher in the HENSD trial while appetite measures were not significantly different between HENSD and PLACEBO trials. Correlations for the within participant relations between the responses of plasma hormones and appetite scores were significant (P < 0.05) for PYY and insulin but not CCK. The energy expended above resting metabolic rate was significantly (P < 0.05) higher in the HENDS trial but relative increase in energy expenditure was not significantly different between the two trials. Conclusion: Oral high-energy nutritional supplements have a partial and relatively short lived suppressive action on energy intake and can be expected to increase net energy intake by approximately half the energy value of the supplement consumed.

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Section: Hensd Placebomentioning

confidence: 99%

Response of appetite and potential appetite regulators following intake of high energy nutritional supplements

et al. 2015

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“…On the other hand, another hypothesis relies on the idea that fermentation of SCFAs influences gut hormones and gastric motility (Brighenti et al 2006;Nilsson et al 2008). Also, other scientific data suggest that the decrease in food intake associated with prebiotics feeding in animals might be linked to the modulation of gastrointestinal peptides involved in the regulation of food intake (Druce et al 2004;Chaudhri et al 2008).…”

Section: Obesity and Diabetesmentioning

confidence: 99%

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

Dominguez

Rodrigues

Lima

et al. 2013

Food Bioprocess Technol

137

108

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Over the past years, many researchers have suggested that deficiencies in the diet can lead to disease states and that some diseases can be avoided through an adequate intake of relevant dietary components. Recently, a great interest in dietary modulation of the human gut has been registered. Prebiotics, such as fructooligosaccharides (FOS), play a key role in the improvement of gut microbiota balance and in individual health. FOS are generally used as components of functional foods, are generally regarded as safe (generally recognized as safe status-from the Food and Drug Administration, USA), and worth about 150€ per kilogram. Due to their nutrition-and health-relevant properties, such as moderate sweetness, low carcinogenicity, low calorimetric value, and low glycemic index, FOS have been increasingly used by the food industry. Conventionally, FOS are produced through a two-stage process that requires an enzyme production and purification step in order to proceed with the chemical reaction itself. Several studies have been conducted on the production of FOS, aiming its optimization toward the development of more efficient production processes and their potential as food ingredients. The improvement of FOS yield and productivity can be achieved by the use of different fermentative methods and different microbial sources of FOSproducing enzymes and the optimization of nutritional and culture parameter; therefore, this review focuses on the latest progresses in FOS research such as its production, functional properties, and market data.

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“…Gut hormones have a variety of physiological actions outside the intestine, and play a central role in linking food ingestion to peripheral nutrient disposal and appetite (3,4). Indeed, glucagon-like peptide-1 (GLP-1) analogs and inhibitors of GLP-1 degradation are now widely prescribed for the treatment of type 2 diabetes, offering additional beneficial effects on body weight compared with conventional insulin secretagogues (5,6).…”

mentioning

confidence: 99%

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

Grosse

Heffron

Burling

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

126

196

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The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lacking the cognate receptor Rxfp4. Plasma Insl5 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding. We conclude that Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.

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Gastrointestinal satiety signals

Cited by 46 publications

References 38 publications

Response of appetite and potential appetite regulators following intake of high energy nutritional supplements

Response of appetite and potential appetite regulators following intake of high energy nutritional supplements

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

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