Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation

Hp, Peters; Wc, Wiersma; Lm, Akkermans; E, Bol; Rj, Kraaijenhagen; Wl, Mosterd; Wr, de Vries; Jp, Wielders

doi:10.1097/00005768-200001000-00020

Cited by 19 publications

(14 citation statements)

References 29 publications

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“…Participants were instructed to refrain from intense, vigorous exercise 48 h prior to data collection (Peters et al 2000). Twenty-four hours prior, participants were provided written and verbal instructions for taking two pills (placebo or naproxen), to consume a small meal prior to reporting to the laboratory, consume fluids to promote euhydration, refrain from all physical activity, and attempt to sleep a "normal" amount.…”

Section: Experimental Design and Proceduresmentioning

confidence: 99%

Effects of a 24-h naproxen dose on hydration and electrolyte measures during moderate-intensity cycling in the heat

Emerson

Torres-McGehee

Davis

et al. 2017

FACETS

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Few controlled laboratory studies have examined the negative effects non-steroidal anti-inflammatory drugs can have on fluid-electrolyte balance during exercise. Our objective was to determine whether a 24-h naproxen dose negatively affected hydration and electrolyte measures before, during, and 3 h after 90 min of cycling in a hot or ambient environment. Using a double blind, randomized and counterbalanced cross-over design, 11 volunteers (six male, five female) completed four trials, with conditions as follows: (1) placebo and ambient, (2) placebo and heat, (3) naproxen and ambient, and (4) naproxen and heat. We found no statistically significant differences among experimental conditions for any dependent measures. Though not statistically significant, mean fluid volume was higher and urine volume was lower during naproxen trials compared with placebos. Mean aggregate plasma sodium was <135 mmol/L at all time points and did not significantly change over time. Overall plasma potassium significantly increased pre-(3.9 ± 0.4) to post-exercise (4.2 ± 0.4 mmol/L, p = 0.02). In conclusion, an acute naproxen dose did not significantly alter hydration-electrolyte balance. The trend for naproxen to increase fluid volume and decrease urine volume suggests the start of fluid retention, which should concern individuals at risk for hyponatremia or with pre-existing cardiovascular conditions.

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Section: Experimental Design and Proceduresmentioning

confidence: 99%

Effects of a 24-h naproxen dose on hydration and electrolyte measures during moderate-intensity cycling in the heat

Emerson

Torres-McGehee

Davis

et al. 2017

FACETS

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“…Most often the type of bleeding is occult and transient, although anecdotal case reports document acute massive upper and lower gastrointestinal bleeding 21. Repeated gastrointestinal bleeding during training and competition may contribute to iron deficiency and anaemia 22.…”

Section: Hazardsmentioning

confidence: 99%

“…Also, endotoxaemia, malabsorption, gastrointestinal tract inflammation, and hypersensitivity reactions have been postulated to occur 1314 21 23All of these effects, however, can mostly be prevented by appropriate dietary (for example, sufficient fluid intake) and other precautions (for example, avoidance of large amounts of aspirin and non-steroidal anti-inflammatory drugs) 1222 …”

Section: Hazardsmentioning

confidence: 99%

Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract

Peters

2001

Gut

268

185

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“…Although diminished blood flow to gastric mucosa during extensive exercise sessions may result in the breakdown of mucosal integrity [30,50], transient changes The anxiolytic effect of exercise Marmara Medical Journal 2016; 29: 135-144 in the gastric mucosal circulation by moderate exercise may have an adaptive preconditioning effect on the mucosal barrier [51] have demonstrated that regular physical exercise results in the up-regulation of endothelial NO synthase gene, and a positive correlation exists between exercise intensity and NO levels. Accordingly, in our study, elevated gastric NO levels in the exercised rats may be involved in the exercise-induced gastroprotection through the vasodilatory effect of NO.…”

Section: Discussionmentioning

confidence: 99%

Regular swimming before the induction of ulcer ameliorates oxidative gastric damage in rats: The anxiolytic effect of exercise

Özbeyli

Mardinoğlu

Temiz

et al. 2017

MMJ

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Objectives:To investigate the impact of exercise on ulcerogenesis. Materials and Methods:Gastric ulcer was induced in Wistar albino rats that were either kept sedentary or had swimming exercise for 6 weeks. Under anesthesia, ulcer was induced by applying acetic acid on the stomach serosa, while control rats had sham-operation. On 3rd or 10th days of ulcer induction, anxiety levels were measured and rats were decapitated for measuring serum cortisol level, while gastric tissue samples were obtained for histopathologic analysis and for determination of malondialdehyde (MDA), glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol-and lucigenin-enhanced chemiluminescence (CL) and nitric oxide (NO) levels. Results:In sedentary 3-day-ulcer group, gastric MPO activities were elevated with concomitant reductions in GSH content, while these changes were reversed in 10-day ulcer group. In exercised 3-day-ulcer group, all parameters were significantly reversed. Increased lucigenin-CL was suppressed, while NO levels were elevated by exercise. Histological analysis revealed lower lesion scores in exercised groups. Serum cortisol levels were not different among ulcer groups, but anxiety was suppressed by swimming exercise in 3-day-ulcer group. Gereç ve Yöntem:Wistar albino sıçanlar, sedanter ve egzersiz grupları olarak ikiye ayrıldı. Altı haftalık egzersizin sonunda, anestezi altında mide serozasına asetik-asit uygulanarak ülser oluşturulurken, kontrol gruplarına taklit-cerrahi yapıldı. Ülser uygulanmasının 3. ve 10. günlerinde, anksiyete düzeyleri belirlendi ve sıçanlar dekapite edildi. Serum kortizol seviyeleri ölçüldü; mide dokusu örnekleri malondialdehit (MDA), glutatyon (GSH), miyeloperoksidaz (MPO), nitrik oksit (NO), luminol-lusigenin probları ile kemiluminesans (KL) ölçümleri ve histopatolojik analiz için alındı. Bulgular: Kontrol gruplarına kıyasla sedanter 3 ve 10 günlük ülser gruplarında MPO ve MDA seviyeleri artarken, GSH seviyeleri azaldı. Bu değişiklikler 10 günlük ülser gruplarında kontrol düzeylerine döndü. Egzersiz yapan 3 günlük ülser grubunda tüm parametreler tersine döndü. Ülser ile artmış bulunan lusigenin KL düzeyi egzersiz ile baskılanırken NO düzeyi egzersizle anlamlı olarak artmış bulundu. Histolojik incelemede egzersiz gruplarında lezyon skorları düşük bulundu. Ülser yapılan sedanter ve egzersiz gruplarında kortizol seviyeleri arasında farklılık görülmedi. Ülsere bağlı artan anksiyete, 3 günlük egzersiz yapan ülser gruplarında azalırken 10 günlük ülser grubunda değişmedi.Sonuç: Düzenli yüzme egzersizi, dokuya nötrofil infiltrasyonunu engellemek, NO yapımını uyarmak ve anksiyeteyi azaltmak yoluyla midede oksidatif hasarı hafifletmektedir. Düzenli egzersiz, mide ülserinin gelişmesini yavaşlatan ve iyileşmesini kolaylaştıran bir yaklaşım olarak dikkate alınmalıdır.

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Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation

Cited by 19 publications

References 29 publications

Effects of a 24-h naproxen dose on hydration and electrolyte measures during moderate-intensity cycling in the heat

Effects of a 24-h naproxen dose on hydration and electrolyte measures during moderate-intensity cycling in the heat

Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract

Regular swimming before the induction of ulcer ameliorates oxidative gastric damage in rats: The anxiolytic effect of exercise

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