Gastrointestinal motility enhancing effect of ginger and its active constituents.

Yamahara, Joji; Huang, Qirong; Li, Yuhao; Xu, Lin; Fujimura, Hajimè

doi:10.1248/cpb.38.430

Cited by 113 publications

(64 citation statements)

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“…It is also useful in case of chills. In India, it is widely consumed in dose of 8-10 g as a flavouring agent (Kelly et al, 2009;al-Yahya et al, 1989;Gong et al, 1989;Stewart et al, 1991;Yamahara et al, 1985;Yamahara et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Potential health benefits and scientific review of ginger

Al-Awwadi¹

2017

J. Pharmacognosy Phytother.

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Ginger has been known for its several scientific properties and valued for the last 2500 years in different parts of the globe. Ginger has rich phytochemistry and several health promoting perspectives. In ginger family, Zingiber officinalis is one of most widely used species and it is found in several foods and beverages. Ginger has been used commonly to treat diarrhea, stomach upset, indigestion and nausea. It also has anti-inflammatory and antioxidant properties. Ginger constituents are 80% moisture, 2% protein, 2% fiber, 1% mineral, 0.9% fat, and 12% carbohydrate. The chemistry of ginger is well documented with the respect to the oleoresin and volatile oil. It is concluded that, ginger has potential to treat numerous disorders including cancer due to its anti-inflammatory and anti-oxidant properties. It is also useful in controlling the process of aging. This scientific review favors ginger due to its rich phytochemistry; however, due to some ambiguities, it is recommended to conduct clinical trials of ginger with sound protocol design before claiming its efficacy.

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Section: Introductionmentioning

confidence: 99%

Potential health benefits and scientific review of ginger

Al-Awwadi¹

2017

J. Pharmacognosy Phytother.

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“…The effect of hydroxy-b -sanshool was significantly inhibited by the capsaicin receptor antagonist, capsazepine (11). Another DKT component, (6)-shogaol, isolated from ginger, is reported to act on gastrointestinal motor neurons and facilitate an intestinal transit of charcoal after oral administration (12). Moreover, Onogi et al have suggested that (6)-shogaol exhibits a capsaicin-like effect on the terminals of primary afferent nerves containing substance P, causing the initial release of neuropeptides and finally depleting the contents of neuropeptides, by subsequent stimulation of the primary afferents (13).…”

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confidence: 99%

Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine

Nakamura

Sakai

Isogami

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-As a way of alleviating severe constipation in cancer patients taking morphine to relieve pain, effects of Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), on gastrointestinal transit in mice or on the isolated guinea pig ileum were studied in special reference to morphine. Without altering the anti-nociceptive effect of morphine, DKT was significantly effective against morphineinduced disorder of gastrointestinal transit in mice as assessed by the charcoal meal test for the intestine and measurement of transit time for the colon tract. The results of in vitro studies with guinea pig ileum suggest that abatement of morphine-induced disorder of transit by DKT is caused by both moderate contraction of morphine-treated longitudinal muscle and relaxation of morphine-induced tonic contraction of circular muscle.

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“…Ginger is very effective in preventing the symptoms of motion sickness, especially seasickness. Ginger reduces all symptoms associated with motion sickness including dizziness, nausea, vomiting, and cold sweating [18]. Some active components of ginger are reported to stimulate digestion, absorption, relieve constipation and flatulence by increasing muscular activity in the digestive tract [19,20].…”

Section: 2 Gastrointestinal Reliefmentioning

confidence: 99%