Gastrointestinal Manifestations of Chagas' Disease

Oliveira, R. B.; Troncon, L E A; Dantas, Roberto Oliveira; Meneghelli, U. G.

doi:10.1111/j.1572-0241.1998.270_r.x

Cited by 151 publications

(148 citation statements)

References 32 publications

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“…Colonic dilatation located in the rectum and sigmoid is better observed by contrast radiography studies and can be detected in up to 80% of cases. However, dilatation can occur only in the rectum, only in the sigmoid, or in the entire colon (277) . It should be emphasized that the clinical picture of severe constipation in patients with idiopathic megacolon who are not infected with T. cruzi is indistinguishable from that induced by Chagas disease (278) .…”

Section: Clinical Diagnosismentioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

309

677

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Section: Clinical Diagnosismentioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

309

677

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“…Before the discovery of H. pylori, the chronic gastritis commonly seen in chagasic patients, most often in those with the digestive form, had been formerly attributed to biliary duodenal-gastric reflux as well as to hypomotility and hypochlorhydria, resulting in injury to the enteric nervous system caused by T. cruzi infection [9][10][11][12] . Later, some studies demonstrated a high prevalence of H. pylori infection in patients with Chagas disease [13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

“…Currently, H. pylori infection is recognized as the main cause of chronic gastritis and is directly linked to the development of peptic ulcer disease as well as gastric carcinoma and MALT lymphoma 4 . Interactions between bacterial virulence, host-related and environmental factors influence the clinical outcome in infected individuals, whereas concurrent infection with other pathogens may also potentially exacerbate or reduce disease severity due to the modulation of the gastric inflammatory process 5-8 .Before the discovery of H. pylori, the chronic gastritis commonly seen in chagasic patients, most often in those with the digestive form, had been formerly attributed to biliary duodenal-gastric reflux as well as to hypomotility and hypochlorhydria, resulting in injury to the enteric nervous system caused by T. cruzi infection [9][10][11][12] . Later, some studies demonstrated a high prevalence of H. pylori infection in patients with Chagas disease [13][14][15][16] .…”

mentioning

confidence: 99%

Seroprevalence of Helicobacter pylori infection in chagasic and nonchagasic patients from the same geographical region of Brazil

Fonseca

Queiroz

Rocha

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:In this study, we evaluated the seroprevalence of Helicobacter pylori infection among chagasic and non-chagasic subjects as well as among the subgroups of chagasic patients with the indeterminate, cardiac, digestive, and cardiodigestive clinical forms. Methods: The evaluated subjects were from the Triângulo Mineiro region, Minas Gerais, Brazil. Chagasic patients showed positive reactions to the conventional serological tests used and were classified according to the clinical form of their disease. Immunoglobulin G antibodies specific to H. pylori were measured using a commercial enzyme-linked immunosorbent assay kit. Results:The overall H. pylori prevalence was 77.1% (239/310) in chagasic and 69.1% (168/243) in non-chagasic patients. This difference was statistically significant even after adjustment for age and sex (odds ratio = 1.57; 95% confidence interval, 1.02-2.42; p = 0.04) in multivariate analysis. The prevalence of infection increased with age in the non-chagasic group (p = 0.007, χ 2 for trend), but not in the chagasic group (p = 0.15, χ 2 for trend). H. pylori infection was not associated with digestive or other clinical forms of Chagas disease (p = 0.27).Conclusions: Our findings demonstrate that chagasic patients have a higher prevalence of H. pylori compared to non-chagasic subjects; a similar prevalence was found among the diverse clinical forms of the disease. The factors contributing to the frequent co-infection with H. pylori and Trypanosoma cruzi as well as its effects on the clinical outcome deserve further study. Keywords: Helicobacter pylori. Chagas disease. Chronic Chagas disease clinical forms. Co-infection. RESUMO Introdução:No presente estudo, foi comparada a soroprevalência da infecção por Helicobacter pylori entre os indivíduos chagásicos e não-chagásicos, bem como entre subgrupos de chagásicos com as formas clínicas indeterminada, cardíaca, digestiva e cardiodigestiva. Métodos: Os indivíduos avaliados eram provenientes da região do Triângulo Mineiro, Minas Gerais, Brasil. Foram realizados testes sorológicos convencionais para diagnóstico da infecção pelo T. cruzi e os chagásicos foram classificados de acordo com a forma clínica. O diagnóstico de infecção por H. pylori foi estabelecido pela detecção de anticorpos IgG específicos utilizando-se um kit comercial de ELISA. Resultados: A prevalência da infecção por H. pylori foi 77,1% (239/310) no grupo de pacientes chagásicos e 69,1% (168/243) no grupo de não-chagásicos. Esta diferença foi estatisticamente significativa mesmo após ajuste para idade e sexo (OR = 1,57; 95% CI, 1,02-2,42; p = 0,04) na análise multivariada. A prevalência da infecção aumentou de acordo com a idade no grupo não-chagásicos (p = 0,007, χ 2 for trend) mas este aumento não foi observado no grupo dos chagásicos (p = 0,15, χ 2 for trend). Não houve associação da infecção por H. pylori com a forma digestiva ou com qualquer outra forma clínica da doença de Chagas (p = 0,27). Conclusões: Foi demonstrado que pacientes chagásicos apresentam maior pre...

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“…Nevertheless, constipation in association with colonic dilatation shown by radiological studies has been reported previously by other authors. 15 In contrast to barium enema, the anorectal manometry test yielded a much higher prevalence of abnormalities in symptomatic Chagas disease patients with constipation than in the asymptomatic ones, suggesting that such motility disturbances are pathogenetically relevant in the constipation associated with Chagas disease. Previous studies in Chagas disease patients have evidenced colonic hypomotility defined by low basal motility index and low wave frequency in the rectosigmoid, and impairment of the anorectal inhibitory reflex.…”

Section: Discussionmentioning

confidence: 97%

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Salvador¹,

Mego²,

Sánchez-Montalvà³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to determine the relationship between colonic symptoms, radiological abnormalities, and anorectal dysfunction in patients with Chagas disease. We performed a cross-sectional study of untreated patients diagnosed with Chagas disease. All patients were evaluated clinically (by a questionnaire for colonic symptoms based on Rome III criteria) and underwent a barium enema and anorectal manometry. A control group of patients with functional constipation and without Chagas disease was included in the study. Overall, 69 patients were included in the study: 42 patients were asymptomatic and 27 patients had abdominal symptoms according to Rome III criteria. Anorectal manometry showed a higher proportion of abnormalities in symptomatic patients than in asymptomatic ones (73% versus 21%, respectively; P 0.0001).

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Gastrointestinal Manifestations of Chagas' Disease

Cited by 151 publications

References 32 publications

2 nd Brazilian Consensus on Chagas Disease, 2015

2 nd Brazilian Consensus on Chagas Disease, 2015

Seroprevalence of Helicobacter pylori infection in chagasic and nonchagasic patients from the same geographical region of Brazil

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

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