Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United States tertiary care medical center

Warrick, Joshua I.; Luo, Jingqin; Robirds, Diane; Branson, Julie; Frater, John L.; Kreisel, Friederike; Hassan, Anjum; Nguyen, Tu Dung T.

doi:10.1186/1746-1596-7-76

Cited by 22 publications

(27 citation statements)

References 46 publications

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“…Regarding North American countries, 2 related studies were performed in the USA and Canada, using 216 and 149 cases, respectively. The results showed that the average age was 61 and 63.8 years, and that the gender ratio was 1.7: 1 and 1.5: 1, respectively [3,18,19] . The gender ratio of this study was similar to that of North American countries and lower than that in India.…”

Section: Discussionmentioning

confidence: 91%

“…For instance, the small intestine was the second most commonly affected site in the research of Warrick et al [19] . The ileocecum region was defined as the section from the terminal of the ileum to the cecum, because of the ambiguity of anatomic classification, the designation for this region was different among previous studies, which has caused the different frequencies of affected small intestinal lymphoma and large intestinal lymphoma [3,18,19] . Thus, in the current study, we isolated this section as an independent area, belonging to neither the small nor the large intestine.…”

Section: Discussionmentioning

confidence: 99%

“…However, the gender ratio of MCL located in the GIT was not mentioned in that report. In the Warrick et al [19] study, 28 cases of GIT MCL were diagnosed with a gender ratio of 1: 1. The striking predominance of GIT MCL cases among men requires verification through further research.…”

Section: Discussionmentioning

confidence: 99%

“…For example, MCL (22%) and FL (21%) comprised a considerable fraction in the North American population, whereas MALT lymphoma accounted for less in this section. MALT lymphoma has been closely associated with Helicobacter pylori infection; therefore, lower rates this infection and its earlier treatment may result in fewer MALT lymphoma diagnoses [19] . In India, BKL was the second most common subtype within the intestine [18] .…”

Section: Discussionmentioning

confidence: 99%

“…However, because some research was only conducted in adults, the comparison of average age is meaningless. The stomach is the main site of GIT involvement with a frequency reported to be between 38.5 and 75% [3,12,14,16,[18][19][20] . In our series, the frequency was 52%.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Lymphoma in Southwest China: Subtype Distribution of 1,010 Cases Using the WHO (2008) Classification in a Single Institution

et al. 2015

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The gastrointestinal tract (GIT) is the most common anatomic site of extranodal non-Hodgkin lymphoma (NHL) involvement. The classification criteria of lymphoma have changed in recent decades, and few large-sample studies regarding subtype analysis of lymphoma have been performed in this site. Aim: Therefore, the present study was conducted to analyze the histological subtype distribution of the GIT. Method: All patients in a single institution with a diagnosis of primary NHL in the GIT were enrolled between January 2007 and April 2014. The patients were categorized according to the WHO (2008) classification of tumors of hematopoietic and lymphoid tissue. Result: A total of 1,010 eligible cases diagnosed as NHL were collected in this study. The male:female ratio was 1.7:1 and the median age was 55 years. The percent of patients with lymphoma involvement in the stomach was 52% (n = 522), and the remaining 48% (n = 484) had intestinal tract involvement. Histologically, diffuse large B cell lymphoma (DLBCL) was the most common subtype in all of the GIT lymphoma cases, and was also the most common subtype in cases involving the stomach (78%) and the intestinal tract (53%). The incidence of DLBCL and mucosa-associated lymphoid tissue lymphoma in the stomach was significantly higher than the incident in the intestinal tract (p < 0.01). T and NK cell lymphoma was significantly more common in the intestinal tract than in the stomach (p < 0.01). Extranodal NK/T cell lymphoma nasal type (ENKTL-N) was the most common subtype of T and NK cell lineage lymphoma in GIT and was also the second most common intestinal tract-involved lymphoma. Conclusion: DLBCL was the most frequent lymphoma in the stomach and in the intestinal tract. T and NK cell lineage lymphoma had a higher occurrence in the intestinal tract than in the stomach. ENKTL-N was the most frequent subtype of lymphoma derived from NK/T cell lineage, and was the second most common lymphoma among all intestinal tract lymphomas.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Lymphoma in Southwest China: Subtype Distribution of 1,010 Cases Using the WHO (2008) Classification in a Single Institution

et al. 2015

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Extranodal lymphomas in the public health system inChile:Analysis of 1251 patients from theNationalAdultCancerProgram

Peña

Russo

Martínez³

et al. 2018

Hematological Oncology

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The aim of the study was to describe the clinical and epidemiological characteristics, anatomic and histologic distribution, and treatment results of extranodal lymphomas (ENLs), diagnosed and treated in the public health system in Chile. We included patients with ENL diagnosed from 1998 to 2014, in 17 cancer centers, registered prospectively in the database of the National Adult Cancer Program (PANDA) of the Ministry of Health. Treatment was based on the local protocols for each lymphoma subtype. Extranodal lymphoma was documented in 1215 of 4907 non-Hodgkin lymphomas diagnosed in that period (25%). Median age was 59 years (range, 16-95), and 55% were female. The gastrointestinal (GI) tract was the most common location (38%), followed by the head and neck (24%) and the skin (15%). B-cell lymphomas accounted for 78% of cases, diffuse large B-cell lymphoma being the most common histologic subtype (68%). Mycosis fungoides/Sezary syndrome was the most frequent T-cell subtype (36%), followed by NK/T-cell lymphomanasal type (24%). In comparison with western countries, Chile showed a significantly high prevalence of NK/T-cell lymphoma nasal type, while the frequency of B-cell ENL and the anatomic distribution appeared similar, being GI the most commonly involved site.

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