Gastrointestinal involvement in non-Hodgkin's lymphoma

Abstract

A total of 813 patients admitted to Roswell Park Memorial Institute from 1963-1972 with non-Hodg-kin's lymphoma (NHL) were reviewed for gastrointestinal (GI) involvement. Primary involvement was found in 71 amid secondary involvement in 31 patients. Occult GI involvement was detected in 46% of the autopsy cases. The median survival time after the diagnosis of secondary GI involvement was nine months. The occuirrence of primary GI-NHL was: 33 in the stomach, 18 in the small intestine, 14 in the ileocecal area iincluding appendix, and 6 in the large intestine. Retrospective staging according to the Ann Arbor staging classification showed 24 to have presented as Stage I, 30 as Stage 11, 4 as Stage 111, and 13 as Stage IV. The primary diagnostic and therapeutic approach was operative, except in 2 patients with rectal lymphtoma. Resection of the principally involved site was carried out in 42 patients. The remainder had pallliative procedures or biopsy examinations only. Postoperative radiation therapy was given to 38 patients. Prognostically important features for primary GI-NHL were: stage; histologic type; site of the primarj disease; and whether or not radiotherapy was administered. The age of the patient, size or degree of local extension, and type of operative procedure were prognostically of no importance. The results of this study would indicate that in Stage I and I1 primary GI-NHL, elective resection is not necessary prior to radiation therapy and that resection alone cannot be considered adequate treatment. A modified staging classification is proposed. Cancer 46:215-222, 1980.

Primary gastric lymphoma – The experience of a General Hospital

“…Those with tumours <10cm had a better survival than those with tumours > 10 cm (P < 0.05 - Figure 3). the past few years (Lim et al, 1977;Lewin et al, __ -1978;Hermann et al, 1980;Weingrand et al, 1982;Brooks & Enterline, 1983) By contrast our study comprises 29 patients r size <nOcm (II alive, 2 dead)s (a) tumour treated in a single institution. While we used Ocm (7 alive1 9 dead).…”

“…As far as the incidence of the various histological categories is concerned our findings are essentially similar to other series (Lim et al, 1977;Lewin et al, 1978;Hermann et al, 1980). Using Rappaport's Classification, we found that only one patient (3.5%) demonstrated a nodular architectural pattern.…”

“…age and sex distribution do not differ essentially with limited disease (stages IA, II1A, II1B) from those published in other series (Lim et al, better survival than those with advanced 1977; Lewin et al, 1978;Hermann et al, 1980). stages 112B and IV -P<0.05).…”

“…Although we do not disagree with the statement that the application of the Ann-Arbor system is problematic in some cases of lymphomas, its modified from used in our study proved to be quite useful as a prognostic determinant, in accordance with the findings of others (Rosenfelt & Rosenberg, 1980;Hermann et al, 1980;Weingrand et al, 1982).…”

Primary gastrointestinal lymphoma in Japan

“…These differences may have been associated with the difference in response to treatment and patient survival. A better prognosis for gastric lymphoma compared with other localizations has been described previously, 1,4,8,11,17,18,21,24,25 although several authors showed no difference in the prognosis between gastric lymphoma and intestinal lymphoma. 5,9,[13][14][15]19,20,22,23 Few publications have shown prognostic data on patients with both gastric and intestinal involvement.…”