Gastrointestinal hormones and bariatric surgery-induced weight loss

Ionut, Viorica; Burch, Miguel; Youdim, Adrienne; Bergman, Richard N.

doi:10.1002/oby.20364

Cited by 136 publications

(99 citation statements)

References 79 publications

(139 reference statements)

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“…The nutritional education after bariatric surgery stressed the importance of a correct protein intake with an overall reduction of fat, with the aim of losing weight, but also of avoiding side effects like steatorrhea. The stomach changes that take place after surgery produce two effects, which could explain the reduction in oral intake: a physical change in the decreased size and a physiological change in the impact on ghrelin secretion [12].…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Diet and Body Composition After Biliopancreatic Diversion

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Relationship Between Diet and Body Composition After Biliopancreatic Diversion

et al. 2015

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“…While mechanical restriction of food intake is a dominating contributor to the weight loss observed after bariatric surgery, weight loss is often greater than expected by restriction alone [6]. There is a growing body of evidence that the hormonal effects of bariatric surgery are also responsible for the weight loss [7]. However, the extent and sustainability of postsurgical weight loss markedly differs between individuals [8].…”

Section: Methodsmentioning

confidence: 99%

“…During the last three decades, the prevalence of obesity has increased enormously, and it is usually assumed that environmental changes are the main causes, although genetic bases can undoubtedly be involved [1]. In 2008, according to the WHO, 1.4 billion adults were overweight and 500 million adults were In SG, a partial gastrectomy is performed, in which the majority of the greater curvature of the stomach is removed and a tubular stomach is created [7]. An SG constitutes the upper abdominal component of the biliopancreatic diversion with a duodenal switch.…”

Section: Introductionmentioning

confidence: 99%

Wpływ gastrektomii rękawkowej na poziom irisiny w surowicy pacjentów z chorobliwą otyłością

Demirpençe¹,

Yilmaz²,

Çolak³

et al. 2016

Endokrynologia Polska

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Introduction: Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG). Materials and methods: Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at three months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin, and irisin levels were measured at each visit. Results: The two groups had similar mean age and sex distribution. Serum irisin was significantly lower in the morbidly obese subjects compared with the controls (p = 0.003) and negatively correlated with BMI, body weight, insulin levels, and HOMA-IR (p = 0.006, p = 0.011, p = 0.046, p = 0.048, respectively). When the morbidly obese patients were re-evaluated three months post-SG, their weight and BMI had significantly decreased (both p = 0.001). Similarly, the insulin, HbA1c, HDL-cholesterol, and HOMA-IR values significantly decreased (p = 0.001, p = 0.028, p = 0.006, and p = 0.001, respectively). However, irisin levels remained unchanged (p = 0,267). Conclusion: Although the irisin levels were significantly lower in the morbidly obese subjects, they did not change after SG-induced weight loss.

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“…43,44 Despite this lack of effective treatments and strategies, some governments are being advised to consider financial penalties for obese patients in regard to health insurance, justified by the belief that obesity is a personal choice. 45 In the USA, the National Institutes of Health has funded the Childhood Obesity Prevention and Treatment Research (COPTR) consortium formed to prevent obesity in preschoolers and treat obesity in 1,700 13-17 year olds.…”

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confidence: 99%

Future management of human obesity: understanding the meaning of genetic susceptibility

Jenkins¹,

Campbell²

2014

AGG

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Gene-environment interactions are central to the expression of obesity. The condition is strongly heritable (ie, genetic), and most of the variation in obesity levels between countries and between individuals can be explained by the effects of obesogenic environments on individual genetic susceptibilities. The nature of the obesogenic environmental influences is not clear in detail, but they correlate closely with measures of affluence. The causes of variation in genetic susceptibility are also not clearly defined, but their general nature has become clearer. The failure of genome-wide association studies or large linkage studies to identify or replicate causative genetic variants, together with the segregation of obesity-related traits in families, implicates a heterogenetic mechanism in which rare, dominantly or additively expressed genetic variants are responsible for most of common obesity. The search for rare causative variants continues with some successes, but those identified contribute very little to the overall burden and, assuming heterogenetics, there are many more to find. The time when genomic risk factors provide more information than do currently available markers, such as family history, is a long way off. Genomic studies to date have contributed little, if anything, to the prevention and treatment of common obesity and its associated disorders. This contrasts with the obvious and immediate potential implications of the well-established overall genetic basis of obesity, which have not yet been exploited in the clinical or public health arenas. Genomic studies, which have helped to define the genetic basis of common obesity mainly by exclusion, will in the future play an increasingly important role in understanding and managing obesity, but only with parallel studies of the physiological, behavioral, and economic influences. Keywords: obesity phenotypes, obesogenic environment, genomics, pathophysiology, treatment, prevention Background and aimsAccording to the World Health Organization projections, by 2015 about 2.3 billion adults in the world will be overweight and over 700 million will be obese, and economic costing predicts that obesity-related expenditure in USA will approach US$100 billion per annum.1 It is now widely, if not universally, accepted that the rising national and global prevalence of overweight and obesity since the 1980s can be understood as the effects of increasingly obesogenic environments (OEs), which are correlated with measures of affluence and food availability, 2 in genetically predisposed individuals. 3,4 Obesity is assessed by the body mass index (BMI, kg/m 2 ) in most epidemiological and genetic studies, often together with measures of central fat distribution such as waist circumference because of adverse metabolic and health associations. However, neither BMI nor other anthropometric measurements are by themselves sufficiently accurate

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Gastrointestinal hormones and bariatric surgery-induced weight loss

Cited by 136 publications

References 79 publications

Relationship Between Diet and Body Composition After Biliopancreatic Diversion

Relationship Between Diet and Body Composition After Biliopancreatic Diversion

Wpływ gastrektomii rękawkowej na poziom irisiny w surowicy pacjentów z chorobliwą otyłością

Future management of human obesity: understanding the meaning of genetic susceptibility

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