Gastrointestinal hemorrhage consequent to foreign body reaction to silk sutures: case series and review

Pecha, R.Eric; Prindiville, Thomas P; Kotfila, Ronald; Ruebner, Boris H.; Cheung, Anthony; Trudeau, Walter L.

doi:10.1016/s0016-5107(98)70196-8

Cited by 15 publications

(10 citation statements)

References 11 publications

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“…Suturing is generally considered the standard technique for wound repair in a wide variety of surgical procedures. However, significant postoperative complications can result from suturing, such as inflammation 1, 2 and scar tissue formation 3, 4, whilst the presence of non‐absorbable suture material can lead to foreign body immune reactions 5. Manual dexterity is often required by the surgeon for suturing, especially during microsurgical procedures.…”

Section: Introductionmentioning

confidence: 99%

In vitro cell compatibility study of rose bengal–chitosan adhesives

et al. 2012

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Section: Introductionmentioning

confidence: 99%

In vitro cell compatibility study of rose bengal–chitosan adhesives

et al. 2012

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“…Significant complications can however occur postoperatively such as inflammation and scar tissue formation, often due to non-absorbable sutures [1]. Manual dexterity is also needed when suturing in keyhole operations that are time consuming.…”

Section: Introductionmentioning

confidence: 99%

Photochemical tissue bonding with chitosan adhesive films

et al. 2010

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BackgroundPhotochemical tissue bonding (PTB) is a promising sutureless technique for tissue repair. PTB is often achieved by applying a solution of rose bengal (RB) between two tissue edges, which are irradiated by a green laser to crosslink collagen fibers with minimal heat production. In this study, RB has been incorporated in chitosan films to create a novel tissue adhesive that is laser-activated.MethodsAdhesive films, based on chitosan and containing ~0.1 wt% RB were manufactured and bonded to calf intestine by a solid state laser (λ = 532 nm, Fluence~110 J/cm2, spot size~0.5 cm). A single-column tensiometer, interfaced with a personal computer, tested the bonding strength. K-type thermocouples recorded the temperature (T) at the adhesive-tissue interface during laser irradiation. Human fibroblasts were also seeded on the adhesive and cultured for 48 hours to assess cell growth.ResultsThe RB-chitosan adhesive bonded firmly to the intestine with adhesion strength of 15 ± 2 kPa, (n = 31). The adhesion strength dropped to 0.5 ± 0.1 (n = 8) kPa when the laser was not applied to the adhesive. The average temperature of the adhesive increased from 26°C to 32°C during laser exposure. Fibroblasts grew confluent on the adhesive without morphological changes.ConclusionA new biocompatible chitosan adhesive has been developed that bonds photochemically to tissue with minimal temperature increase.

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“…However, in many instances the suture is either unable to effect repair or the repair that occurs interferes with the functional rehabilitation of the site. Examples of this include closure of lung tissue following resection (air leakage), nerve repair (scarring and lack of conduction), abdominal repairs (leading to adhesions), and traumatic injuries (agglomeration of many small lesions) [1][2][3][4]. In these cases, various surgical glues and adhesives have often been used as alternatives.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo tissue repair with laser‐activated chitosan adhesive

et al. 2006

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Background and Objectives: Sutures are currently the gold standard for wound closure but they are still unable to seal tissue and may induce scarring or inflammation. Biocompatible glues, based on polysaccharides such as chitosan, are a possible alternative to conventional wound closure. In this study, the adhesion of laser-activated chitosan films is investigated in vitro and in vivo. In particular we examine the effect of varying the laser power, as well as adding a natural cross-linker (genipin) to the adhesive composition. Study Design/Materials and Methods: Flexible and insoluble strips of chitosan films (surface area $34 mm 2 , thickness $20 mm) were bonded to sheep intestine using several laser powers (0, 80, 120, and 160 mW) at 808-nm wavelength. The strength of repaired tissue was tested by a calibrated tensiometer to select the best power. A natural cross-linker (genipin) was also added to the film and the tissue repair strength compared with the strength of plain films. The adhesive was also bonded in vivo to the sciatic nerve of rats and the thermal damage induced by the laser assessed 4 days post-operatively. Results: Chitosan adhesives successfully repaired intestine tissue, attaining a maximum repair strength of 14.7 AE 4.3 kPa (n ¼ 30) at the laser power of 120 mW. The chitosan-genipin films achieved lower repair strength (9.1 AE 2.9 kPa). The laser caused partial demyelination of axons at the site of operation, but the myelinated axons retained a normal morphology proximally and distally. Conclusions: The chitosan adhesive effectively bonded to tissue causing only localized thermal damage in vivo, when the appropriate laser parameters were selected.

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Gastrointestinal hemorrhage consequent to foreign body reaction to silk sutures: case series and review

Cited by 15 publications

References 11 publications

In vitro cell compatibility study of rose bengal–chitosan adhesives

In vitro cell compatibility study of rose bengal–chitosan adhesives

Photochemical tissue bonding with chitosan adhesive films

In vitro and in vivo tissue repair with laser‐activated chitosan adhesive

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