Gastrointestinal Diseases in Women

Borum, Marie L.

doi:10.1016/s0025-7125(05)70593-9

Cited by 13 publications

(1 citation statement)

References 140 publications

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“…The ultimate purpose of studying persons with IBS is to examine the effects of experiencing a noninflammatory (Bayless and Harris 1990;others 1990, 1991;Drossman and Thompson 1992;Longstreth and Wolde-Tsadlik 1993;American Gastroenterological Association Patient Care Committee 1997;Borum 1998), chronic health disturbance and its inherent physical and psychological symptom distress on NK cell activity. For persons with IBS, the principal physical distress is abdominal pain or discomfort (Manning and others 1978;Thompson and others 1999).…”

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confidence: 99%

Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome

Motzer

Jarrett²,

Heitkemper³

et al. 2002

Biological Research For Nursing

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The primary purpose of this exploratory study was to compare percentages of natural killer (NK) cells and activated NK and T cells, and both cytotoxic and in vitro cytokine production activity in women with and without symptomatic irritable bowel syndrome (IBS). A secondary purpose was to examine the relationships of psychological distress and low sense of coherence with immune function indicators and stress hormones. NK cell percentage and activity have been shown to vary in response to many psychological and physiological stressors. The authors compared 2 groups of women: symptomatic IBS (n = 12) and control (n = 12). Between-subject variability for all immune measures was large. The percentage of activated NK and Tcells was significantly lower in the IBS group compared to control (Mann-Whitney U = 30, P = 0.05). Relationships were significant between activated NK and T cell percentage and depression, anxiety, and overall distress (r = -0.54, -0.49, and -0.47, respectively, P < 0.03) and between interferon-gamma production and anxiety (r = -0.45, P < 0.03). There was a trend toward a positive relationship between sense of coherence and NK cytotoxicity (r = 0.39, P = 0.11). Thesefindings are important because they suggest that nursing interventions targeting ongoing physical and psychological distress might also be helpful in improving immune function.

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confidence: 99%

Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome

Motzer

Jarrett²,

Heitkemper³

et al. 2002

Biological Research For Nursing

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Increased susceptibility toHelicobacter pylori infection in pregnancy

Lanciers

Despinasse

Mehta

et al. 1999

Infect. Dis. Obstet. Gynecol.

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OBJECTIVE: Helicobacter pylori plays a major role in abdominal symptoms and gastroduodenal pathology, including gastric cancer. Pregnancy has been associated with changes in both humoral and cell-mediated immunity. These changes include alterations in the various classes of antibodies during different gestational periods. It has been previously suggested that these alterations may expose pregnant women to an increased risk of infection with this microorganism. METHODS: To further investigate this hypothesis, we assayed sera from 229 asymptomatic pregnant women for the presence of H.-pylori-specific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies by means of a commercially available serum ELISA test (Malakit, Biolab, Belgium). Both tests were previously validated in large series of H.-pylori-positive and -negative subjects. While the presence of H.-pylori-specific IgG antibodies is only a marker for a "chronic" infection with this bacterium and therefore no indicator of the time of acquisition of the infection, specific IgM antibodies are a more specific marker for a recently acquired infection with H. pylori. Results were compared with those previously obtained in asymptomatic, healthy, nonpregnant individuals. RESULTS: One hundred twenty of 229 women (52.4%) and 55/118 nonpregnant subjects (46.6%) were seropositive for H.-pylori-specific IgG antibodies (P > 0.3). Out of these 120 IgG-antibody-positive women, 36 (30%) were positive for H.-pylori-specific IgM antibodies, as were 25/109 (22.9%) in the IgG-antibody-negative group (P > 0.3). Overall, 61/229 (26.6%) of the pregnant women had recently been infected with H. pylori, compared with 11% of the healthy, nonpregnant population (P > 0.01). CONCLUSIONS: Our observations confirm the possibility of an increased susceptibility to H. pylori infection in pregnancy. Additional studies are necessary to further understand the immune response to H. pylori in pregnancy.

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Treatment of Irritable Bowel Syndrome: Sex and Gender Specific Aspects

Voß

Lewerenz²,

Nieber

2012

Sex and Gender Differences in Pharmacology

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Patients with functional gastrointestinal disorders constitute the majority of patients seeking healthcare for gastrointestinal symptoms in primary and secondary care. Of these disorders irritable bowel syndrome (IBS) is one of the most common and affects 10-20% in the Western world. IBS is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. Sex and gender aspects are important in understanding differences between men and women in their risk and experience of IBS. Relative to men, women are diagnosed more frequently with IBS. Female patients are more likely to be constipated, complain of abdominal distension and of certain extracolonic symptoms. Given the variability of IBS, the most successful treatment will be comprehensive, involving multiple strategies. Efficacy, safety and tolerability are important in the evaluation of IBS therapies, as patients are likely to require long-term treatment. Laxatives, antidiarrheals or antispasmodics are common in the treatment of IBS but the majority of patients receive antispasmodics followed by prokinetic agents. In treatment of IBS there appears to be a greater clinical response to serotonergic agents developed for IBS in women compared to men. There is an absence of drugs licensed specifically for the treatment of IBS. Further studies with novel agents are needed, to evaluate new approaches to IBS management including gender specific behavioral therapies and better characterization of patient subgroups with regard to drug therapy so that personalized therapy can be tested.

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Gastrointestinal Diseases in Women

Cited by 13 publications

References 140 publications

Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome

Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome

Increased susceptibility toHelicobacter pylori infection in pregnancy

Treatment of Irritable Bowel Syndrome: Sex and Gender Specific Aspects

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