Gastrointestinal Delivery of APIs from Chitosan Nanoparticles

Sabra, Rayan; Billa, Nashiru

doi:10.5772/intechopen.95363

Cited by 5 publications

(3 citation statements)

References 112 publications

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“…NPs swelled significantly and even dissociated rapidly, resulting in the quick model drug release [ 132 ]. The cumulative release of drugs from CSNPs could indicate that drug release was faster at lower pH than at neutral or higher pH [ 133 ].…”

Section: Drug Release From Csnpsmentioning

confidence: 99%

Drug release study of the chitosan-based nanoparticles

Herdiana

Wathoni

Shamsuddin

et al. 2022

Heliyon

205

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Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.

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Section: Drug Release From Csnpsmentioning

confidence: 99%

Drug release study of the chitosan-based nanoparticles

Herdiana

Wathoni

Shamsuddin

et al. 2022

Heliyon

205

View full text Add to dashboard Cite

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“…These NPs can influence the expression and function of enzymes such as cytochrome P450 (CYP) enzymes, which are responsible for the metabolism of many drugs. CSNPs have been shown to inhibit certain CYP enzymes, leading to decreased drug metabolism and increased systemic exposure to the active drug [116,117].…”

Section: Metabolismmentioning

confidence: 99%

Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

et al. 2023

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Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body’s internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.

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“…[52] The main biomaterials used in transdermal DDS are lipids, [53][54][55][56] hyaluronic acid, [57] and chitosan. [58] Chitosan was employed as NPs, [59,60] microneedles (MN), [61] CPEs, [62] nanofibers, [63] dermal patches and films, [64] and nanogels. [65] Wang et al used a hybrid biopolymer adhesive made of PDMS-gum Arabic in a morphology bioinspired by the microscale array of the sticky mucilage pillars secreted by the Sundew plant to catch prey.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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Gastrointestinal Delivery of APIs from Chitosan Nanoparticles

Cited by 5 publications

References 112 publications

Drug release study of the chitosan-based nanoparticles

Drug release study of the chitosan-based nanoparticles

Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

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