Gastrointestinal and Hepatic Manifestations of Ebola Virus Infection

Sharma, Nisha; Cappell, Mitchell S.

doi:10.1007/s10620-015-3691-z

Cited by 20 publications

(12 citation statements)

References 69 publications

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“…However, the mild elevation of bilirubin and the observation that AST levels were steadily much higher than those of ALT suggest that severe acute viral hepatitis is not a typical manifestation of EVD subsequent to EBOV. [35][36] Similar evidence has been reported in clinical studies in patients infected either with Sudan Ebola or [26] Taï Forest Ebola [37] and in animal model investigating pathogenesis of Bundibugyo Virus. [38] In conclusion, our study provides new evidence to support the hypothesis that EBOV may play a direct role in muscular damage and imbalance of coagulation system.…”

Section: Discussionsupporting

confidence: 73%

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study

Lanini

Portella²,

Vairo

et al. 2017

Clinical Infectious Diseases

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Section: Discussionsupporting

confidence: 73%

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study

Lanini

Portella²,

Vairo

et al. 2017

Clinical Infectious Diseases

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“…SARS-CoV-2 indirectly damages the digestive system through an inflammatory response chain (Musa, 2020). In addition, in other cases, Ebola and Lassa viral infections, it is said that GIT manifestations dominate at the beginning of symptoms (Sharma and Cappell, 2015), (Dongo et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

A Case Report Respiratory Manifestations of Covid-19 Starting With a Gastrointestinal Complaint: A Coincidence or a Correlation?

Veterini¹,

Andriyanto²,

Hamzah³

2021

AJID

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Background: SARS COV-2 is the cause of the current outbreak of COVID-19. The infection of SARS COV-2 causes changes in the gut- lung axis and the intestinal microbiota pro-inflammatory cytokines interaction which leads to the injury of the gastrointestinal tract. One of the symptoms of COVID-19 outside the respiratory system is a complaint in the GIT. Materials and Methods: We present a COVID-19 case report that begins with a complaint of abdominal pain. Results: There was no previous suspicion of COVID-19, but after a radiological examination and SARS-COV2 positive PCR result, the patient was proven to be suffering from COVID-19. Conclusion: After hospitalization in the ICU for about 14 days, a recovery occurred and the patient was able to go home in a very good clinical condition.

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“…Gastrointestinal symptoms are among the earliest, most common, and life-threatening clinical manifestations of EVD in humans [9]. In the 2014 outbreak in Western Africa, results of a study found that among patients admitted to the hospital with confirmed EVD, the most common clinical syndrome was one of gastrointestinal illness, intravascular volume depletion, and related complications [10].…”

Section: Introductionmentioning

confidence: 99%

Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells

Tamhankar

Gerhardt

Bennett

et al. 2018

Virol J

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BackgroundCurrently, no FDA-approved vaccines or treatments are available for Ebola virus disease (EVD), and therapy remains largely supportive. Ebola virus (EBOV) has broad tissue tropism and can infect a variety of cells including epithelial cells. Epithelial cells differ from most other cell types by their polarized phenotype and barrier function. In polarized cells, the apical and basolateral membrane domains are demarcated by tight junctions, and specialized sorting machinery, which results in a difference in composition between the two membrane domains. These specialized sorting functions can have important consequences for viral infections. Differential localization of a viral receptor can restrict virus entry to a particular membrane while polarized sorting can lead to a vectorial virus release. The present study investigated the impact of cell polarity on EBOV infection.MethodsCharacteristics of EBOV infection in polarized cells were evaluated in the polarized Caco-2 model grown on semipermeable transwells. Transepithelial resistance (TEER), which is a function of tight junctions, was used to assess epithelial cell polarization. EBOV infection was assessed with immunofluorescence microscopy and qPCR. Statistical significance was calculated using one-way ANOVA and significance was set at p < 0.05.ResultsOur data indicate that EBOV preferentially infects cells from the basolateral route, and this preference may be influenced by the resistance across the Caco-2 monolayer. Infection occurs without changes in cellular permeability. Further, our data show that basolateral infection bias may be dependent on polarized distribution of heparan sulfate, a known viral attachment factor. Treatment with iota-carrageenan, or heparin lyase, which interrupts viral interaction with cellular heparan sulfate, significantly reduced cell susceptibility to basolateral infection, likely by inhibiting virus attachment.ConclusionsOur results show cell polarity has an impact on EBOV infection. EBOV preferentially infects polarized cells through the basolateral route. Access to heparan sulfate is an important factor during basolateral infection and blocking interaction of cellular heparan sulfate with virus leads to significant inhibition of basolateral infection in the polarized Caco-2 cell model.

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Gastrointestinal and Hepatic Manifestations of Ebola Virus Infection

Cited by 20 publications

References 69 publications

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study

A Case Report Respiratory Manifestations of Covid-19 Starting With a Gastrointestinal Complaint: A Coincidence or a Correlation?

Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells

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