Gastroesophageal reflux in diabetes mellitus

Lluch, Irene; Ascaso, Juan F.; Mora, Francisco; Mínguez, Miguel; Peña, Andrés; Hernández, Antonio; Benages, A

doi:10.1016/s0002-9270(99)00042-8

Cited by 56 publications

(52 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Esta interpretação implica em questionar a associação entre sintomas digestivos e as alterações fisiopatológicas trazidas pelas complicações gastrintestinais do diabetes, tão bem demonstradas em inúmeros trabalhos [2][3][4][5][6][7][23][24][25] . A dissociação entre sintomas e alterações motoras no diabetes tem sido comprovada, por outro lado, em estudos que demonstram alta freqüência de refluxo gastro-esofageano 26 ou de retarde do esvaziamento gástrico 24 em diabéticos completamente assintomáticos. Nestes casos, a ausência de sintomas pode ser explicada pelo comprometimento das vias neurais aferentes, como parte do quadro de neuropatia diabética 27 , do que pode resultar diminuição considerável da sensibilidade visceral.…”

Section: Tabela 2 -Freqüência De Sintomas Digestivos Nos Grupos De DIunclassified

Freqüência de sintomas digestivos em pacientes brasileiros com Diabetes Mellitus

Troncon¹,

Lopes²,

Simão³

et al. 2001

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

INTRODUÇÃOO Diabetes Mellitus é uma doença metabólica crônica, muito freqüente em todo o mundo, que pode afetar muitos órgãos e aparelhos 1 . No aparelho digestivo, em particular, é relativamente bem conhecida a ocorrência de complicações do Diabetes Mellitus, como os distúrbios da motilidade do tubo digestivo e as alterações da absorção de água e de eletrólitos diabéticos, com análise comparativa à freqüência encontrada na população geral, não são muito numerosos [5][6][7][8][9][10][11] . Além disso, em pelo um destes estudos, feito em amostra expressivamente numerosa, a prevalência de sintomas gastrointestinais nos pacientes diabéticos não foi significativamente diferente da verificada em controles 10 . É sabido que os sintomas das diversas condições mórbidas e, em especial, os relacionados ao aparelho digestivo, constituem manifestações clínicas subjetivas, que são passíveis de serem influenciadas por fatores externos, como os ligados aos aspectos culturais, à raça, à dieta e ao clima, entre outros. Assim sendo, é lícito supor que os resultados de estudos sobre prevalência de sintomas em diabéticos realizados no hemisfério Norte

show abstract

Section: Tabela 2 -Freqüência De Sintomas Digestivos Nos Grupos De DIunclassified

Freqüência de sintomas digestivos em pacientes brasileiros com Diabetes Mellitus

Troncon¹,

Lopes²,

Simão³

et al. 2001

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…An increased susceptibility to secondary GI infections has also been mentioned [2, 3]. The prevalence of GI symptoms in diabetic patients has been investigated in several studies, but with diverging results [4, 5, 6, 7]. For instance, by using self-administered, mailed questionnaires, results were obtained that showed no differences in the prevalence of GI symptoms when diabetic patients were compared to controls [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Symptoms in Type 1 Diabetic Patients, as Compared to a General Population

Mjörnheim¹,

Finizia²,

Blohmé³

et al. 2003

Digestion

View full text Add to dashboard Cite

Objectives: To examine the prevalence of gastrointestinal (GI) symptoms in patients with type 1 diabetes as compared to age- and sex-matched controls. Method: 395 patients with type 1 diabetes, registered at the diabetes outpatient unit at the Sahlgrenska University Hospital, were studied by use of a GI symptom questionnaire. They were randomly selected within 10-year age intervals from 20 to 69 years. Age- and sex-matched controls (n = 242) were sampled from a cohort recruited from the general population. Results: While the study populations were well matched with regard to age, sex and body mass index (BMI), the diabetic population comprised more smokers and reported symptoms of respiratory and ischemic heart disease more frequently. Symptoms of heartburn, acid regurgitation, nausea and vomiting were significantly more frequent and intense in the diabetic cohort. The occurrence of GI symptoms co-varied with the presence of respiratory and cardiac symptoms but was not predicted by age, glycosylated haemoglobin (HbA1c) levels or the presence of peripheral neuropathy. Conclusion: Patients with diabetes type 1 had more frequent and intense upper and lower GI symptoms than age- and sex-matched controls, especially if only moderate and severe symptoms were considered. The presence of symptoms was related to lifestyle factors but not to the degree of diabetes control as expressed by the level of HbA1c and the presence of peripheral neuropathy.

show abstract

“…13,20 Still, prevalence of the disease in our study was higher than that of other similar questionnaire studies in Japan (23-29%) 16,18 and Korea (23.1%). 19 Our result even topped prevalence in Spain (28%) which also used ambulatory 24-hour esophageal pH-monitoring, 17 so that its result should have been higher consequently due to inclusion of asymptomatic GERD in DM patients.…”

Section: Discussionmentioning

confidence: 71%

“…4,[12][13][14][15] Studies conducted in various countries have shown that GERD was a frequent complication in approximately 23-29% of DM patients and reached up to half of total diabetes cases in New Jersey, United States. [15][16][17][18][19][20] Another complexity of DM in the case of GERD is that DM will give poor prognostic effect to the latter since: (1) DM will reduce the effectiveness of acid-suppression therapy, which is the mainstay therapy of GERD 21 and; (2) DM increases the occurrence of Barrett's esophagus and esophageal cancer. 22 The presence of GERD in DM patients is often missed.…”

mentioning

confidence: 99%

Gastro-esophageal reflux disease among type-2 diabetes mellitus patients in a rural area

et al. 2015

View full text Add to dashboard Cite

ABSTRAK p = 0,048). Adapun lama DM,[2][3][4][5][6][7][8][9][10][11][12][13] p = 0,976), obesitas (37% vs 38%, p = 0,897), usia (53,2 ± 10,5 vs 54,7 ± 9,3, p = 0,481) ABSTRACTBackground: One of the most neglected complications of diabetes mellitus (DM) is gastro-esophageal reflux disease (GERD) which arises from autonomic neuropathy and diabetic gastropathy related to the extent of DM. This study was done to find prevalence of GERD in DM patients with GERD-questionnaire (GERDQ), dietary factor proportion, and their association with other GERD risk factor in rural area.Methods: This cross sectional study was conducted in Puskesmas Pelaihari from August to September 2013. Subjects with DM aged ≥ 18 were selected consecutively from both newly and previously diagnosed patients with exclusion criteria: pregnancy, in proton-pump inhibitor therapy, and had other metabolic disease(s). DM was diagnosed with ADA criteria, while GERD was diagnosed in patients with score of ≥ 8 of Indonesian GERDQ.Results: There were 30 subjects (29.7%) with GERD among 101 patients with DM and dietary factors found in GERD patients were spicy diet (90%), high-fat food (90%), irritative beverages (87%), and irritative diet (23%). Only female gender was associated with GERD vs non-GERD in DM patients (87% vs 68%, p = 0.048). Meanwhile, duration of DM (2 [0-13] vs 2 [0-19], p = 0.976), obesity (37% vs 38%, p = 0.897), age (53.2±10.5 vs 54.7 ± 9.3, p = 0.481), and uncontrolled diabetes (90% vs 94%, p = 0.421) were not associated with the GERD among DM patients. Conclusion:Prevalence of GERD in DM is somewhat high in this study. Female group with DM needs to be screened for GERD as early as possible.

show abstract

Gastroesophageal reflux in diabetes mellitus

Cited by 56 publications

References 25 publications

Freqüência de sintomas digestivos em pacientes brasileiros com Diabetes Mellitus

Freqüência de sintomas digestivos em pacientes brasileiros com Diabetes Mellitus

Gastrointestinal Symptoms in Type 1 Diabetic Patients, as Compared to a General Population

Gastro-esophageal reflux disease among type-2 diabetes mellitus patients in a rural area

Contact Info

Product

Resources

About