Gastroesophageal Reflux Disease: Pathophysiology

Valezi, Antonio Carlos; Herbella, Fernando A. M.; Mali, Jorge

doi:10.1007/978-3-319-04337-1_3

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…It creates a flap at the esophagogastric junction, a longer distance between the stored food in the fundus and the esophagus, and projects the fundus toward the esophagus during gastric distention. 5 Reflux occurs in cadavers if the angle of His is made more obtuse. 27 There is no evidence that the angle of His is different in obesity.…”

Section: Pathophysiologymentioning

confidence: 98%

Gastroesophageal reflux disease in the obese: Pathophysiology and treatment

Nadaleto

Herbella

Patti

2016

Surgery

125

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Section: Pathophysiologymentioning

confidence: 98%

Gastroesophageal reflux disease in the obese: Pathophysiology and treatment

Nadaleto

Herbella

Patti

2016

Surgery

125

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“…The more acute this angle, the more the gastric fundus will be projected toward the esophagus as gastric distension occurs during a meal. The deposition of fat in the gastroesophageal junction, common and excessive in obese individuals, can make this angle obtuse [17].…”

Section: Defective Gastroesophageal Barriermentioning

confidence: 99%

Pathophysiology of Gastroesophageal Reflux Disease in Obese Patients

Patti

Schlottmann

Farrell

2020

The Perfect Sleeve Gastrectomy

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“…The phrenoesophageal membrane is a fibro‐elastic ligament consisting in the continuation of the transversalis fascia that leaves the diaphragm and surrounds the esophagus in a variable distance from the abdominal inlet. The membrane protects against reflux transmitting the positive abdominal through the hiatus up to the insertion of the membrane in the esophagus [23].…”

Section: Valvular Mechanism Versus Transdiaphragmatic Pressure Gradientmentioning

confidence: 99%

“…Gubaroff valves consist in a cushion action of the distal esophageal mucosa at the level of the esophagogastric junction [23].…”

Section: Valvular Mechanism Versus Transdiaphragmatic Pressure Gradientmentioning

confidence: 99%

Pathophysiology of Gastroesophageal Reflux Disease

Menezes

Herbella

2017

World j. surg.

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Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaphragmatic pressure gradient. Antireflux mechanisms include the lower esophageal sphincter and abdominal esophagus, the diaphragm, the angle of His, the Gubaroff valve, and the phrenoesophageal membrane. Protective mechanisms include esophageal motility, saliva production, and epithelial protection. Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases).

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Gastroesophageal Reflux Disease: Pathophysiology

Cited by 5 publications

References 15 publications

Gastroesophageal reflux disease in the obese: Pathophysiology and treatment

Gastroesophageal reflux disease in the obese: Pathophysiology and treatment

Pathophysiology of Gastroesophageal Reflux Disease in Obese Patients

Pathophysiology of Gastroesophageal Reflux Disease

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