Pathophysiology of Gastroesophageal Reflux Disease in Obese Patients

Patti, Marco G.; Schlottmann, Francisco; Farrell, Timothy M.

doi:10.1007/978-3-030-28936-2_14

Cited by 2 publications

(5 citation statements)

References 45 publications

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“…Obesity triples the chance of developing GERD [ 104 ] and doubles the risk of erosive esophagitis [ 105 ]. Moreover, the prevalence of GERD is proportional to the severity of obesity [ 106 ]. The prevalence of GERD symptoms in patients with morbid obesity reaches 50% [ 107 ].…”

Section: The Role Of Obesity In Be and Eac Developmentmentioning

confidence: 99%

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Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Bilski

Pinkas

Wójcik

et al. 2022

IJMS

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Both obesity and esophageal adenocarcinoma (EAC) rates have increased sharply in the United States and Western Europe in recent years. EAC is a classic example of obesity-related cancer where the risk of EAC increases with increasing body mass index. Pathologically altered visceral fat in obesity appears to play a key role in this process. Visceral obesity may promote EAC by directly affecting gastroesophageal reflux disease and Barrett’s esophagus (BE), as well as a less reflux-dependent effect, including the release of pro-inflammatory adipokines and insulin resistance. Deregulation of adipokine production, such as the shift to an increased amount of leptin relative to “protective” adiponectin, has been implicated in the pathogenesis of BE and EAC. This review discusses not only the epidemiology and pathophysiology of obesity in BE and EAC, but also molecular alterations at the level of mRNA and proteins associated with these esophageal pathologies and the potential role of adipokines and myokines in these disorders. Particular attention is given to discussing the possible crosstalk of adipokines and myokines during exercise. It is concluded that lifestyle interventions to increase regular physical activity could be helpful as a promising strategy for preventing the development of BE and EAC.

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Section: The Role Of Obesity In Be and Eac Developmentmentioning

confidence: 99%

“…Impaired esophageal motility could also lead to abnormal esophageal clearance [ 114 , 115 ]. Abdominal obesity may predispose to disruption of the anatomic gastroesophageal junctions, causing hiatal hernia formation [ 106 , 119 ].…”

Section: The Role Of Obesity In Be and Eac Developmentmentioning

confidence: 99%

Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Bilski

Pinkas

Wójcik

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…71 Fat deposition around the gastroesophageal junction can make the angle of His—another important landmark of the ARB—more obtuse and lead to reflux. 72 Also, hiatal hernias are more frequently found in patients with obesity, 73 and manometric studies demonstrate a progressive disruption of the GEJ anatomy with obesity. 74…”

Section: Pathophysiological Consideration Of Gerd After Lsgmentioning

confidence: 99%

“…Patients with obesity more frequently have decreased salivation and impaired esophageal peristalsis compared to lean individuals. 72,75…”

Section: Pathophysiological Consideration Of Gerd After Lsgmentioning

confidence: 99%

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Physiological Archetypes of de novo Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy

Ottoboni Brunaldi,

Ghanem,

Abu Dayyeh

2023

Foregut: The Journal of the American Foregut Society

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Laparoscopic Sleeve Gastrectomy (LSG) is the most common bariatric surgery in the world. While clinically effective, recent studies have shown increasingly higher rates of gastroesophageal reflux disease (GERD) and esophageal motility disorders. We reviewed all the literature and unraveled the underlying mechanism of post-LSG GERD. Finally, we propose a new classification to help us understand the disease and guide work-up, treatment, and future refinements in the surgical technique.

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Pathophysiology of Gastroesophageal Reflux Disease in Obese Patients

Cited by 2 publications

References 45 publications

Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Physiological Archetypes of de novo Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy

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