Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis, and therapy

Abstract

Gastroesophageal re¯ux disease (GERD) and asthma are common. Some 3±10% of the adult and 8±13% of the pediatric population have asthma (1, 2). More than one-third of the total adult US population have intermittent symp-

Asthma and overweight are associated with symptoms of gastro‐oesophageal reflux

“…However, selected asthmatics without control groups have been included [5]. A causative relation is still unclear [6], even if mechanisms of GERD as a cause of asthma and asthma-provoking GERD have been proposed [7].…”

Asthma under control is inversely related with erosive esophagitis among healthy adults

“…The previous researches were performed among patients who were already diagnosed for one of the diseases. Most patients with mild gastroesophageal reflux do not know about their condition or do not see doctors, relying on over-the-counter antacids for symptom relief and usually take years to seek medical help [23]. Therefore, those in early stages could not be counted in the general statistics.…”

Agreement between upper respiratory diagnoses from self‐report questionnaires and medical records in an occupational health setting

“…Unique to this population of first responders with physically demanding jobs, rhinosinusitis makes it difficult for firefighters to wear respirators, a requirement for the safe performance of their duties. In addition, GERD may lead to laryngopharyngeal reflux (LPR) and/or bronchospasm [Theodoropoulos et al, ] which could be life‐threatening if it were to occur in a fire or rescue situation. While not necessarily life threatening for non‐emergency workers, proper screening and treatment of GERD and rhinosinusitis will likely improve work performance [Joish et al, ; Gisbert et al, ; Bhattacharyya, ].…”