Asthma and overweight are associated with symptoms of gastro‐oesophageal reflux

Størdal, Ketil; Jóhannesdóttir, Gróa B.; Bentsen, Beint S.; Carlsen, Karin C. Lødrup; Sandvik, Leiv

doi:10.1080/08035250600589041

Cited by 40 publications

(32 citation statements)

References 29 publications

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“…Our study was the first to investigate EBC concentrations of calcium and magnesium in GERD patients, so we can only speculate on the physiologic function of these parameters. GERD symptoms are known to be possibly confused with acute asthma symptoms, thus leading to inappropriate therapeutic approach (22,25). In addition, GERD is present in approximately two-thirds of asthmatic children (48) and can contribute to asthma exacerbation.…”

Section: Discussionmentioning

confidence: 99%

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Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Dodig

Vlašić

Čepelak

et al. 2009

Clinical Laboratory Analysis

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Background: Magnesium and calcium physiologic functions are closely related. Magnesium is primarily an intracellular cation, the action of which also involves maintenance of cellular ionic balance, while influencing calcium homeostasis by blocking calcium channels. The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD).Subjects and methods: EBC was collected from 66 children aged 7–14 years (23 children with acute asthma, 17 children with GERD, and 26 healthy children).Determination of magnesium and calciumconcentrations was preceded by optimization and validation for low concentrations.Results: No difference was recorded for either magnesium or calcium concentration between study groups. However, the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group.Conclusion: Study results showed the magnesium to calcium ratio to be a statistically significantly better indicator of certain pathologic changes than absolute concentration of either ion. J. Clin. Lab. Anal. 23:34–39, 2009. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

“…Asthma was chosen for the presence of bronchoconstriction, and GERD because the symptoms may occasionally be erroneously attributed to asthma, thus leading to inappropriate therapeutic approach (22,25).…”

Section: Introductionmentioning

confidence: 99%

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Dodig

Vlašić

Čepelak

et al. 2009

Clinical Laboratory Analysis

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show abstract

“…A populationbased birth cohort showed that the association between reflux symptoms and respiratory symptoms in young adults was independent of BMI [113]. Overweight did not explain the higher frequency of GERD in asthma patients [114].…”

Section: Gastro-oesophageal Refluxmentioning

confidence: 99%

Comorbidities of asthma during childhood: possibly important, yet poorly studied

Groot

Duiverman²,

Brand³

2010

Eur Respir J

106

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Asthma in adults is associated with comorbidities such as obesity, gastrooesophageal reflux, dysfunctional breathing and mental disorders. Herein, we provide an overview of the current state of evidence on these comorbidities in childhood asthma. The prevalence, known mechanisms and possible treatment options for each comorbid condition will be discussed.Obesity is an increasing health problem in children, but its relationship with asthma remains unclear. Allergic rhinitis is a very common comorbidity in asthma, both in children and in adults, but its effect on childhood asthma severity has not been studied. The prevalence and treatment options of dysfunctional breathing, a known comorbidity in adult asthma, have not yet been studied in paediatric asthma. Food allergies appear to cause more severe reactions in patients with asthma. Depressive disorders are more prevalent in childhood asthma than in healthy children, but seem to be poorly recognised and treated in children. Although gastro-oesophageal reflux is commonly thought to be a comorbid disease complicating asthma, it remains uncertain whether treatment improves asthma control.In conclusion, knowledge of asthma comorbidities in childhood is sparse. Further studies are urgently needed to identify the prevalence, and, more importantly, the effects of these comorbidities and their treatment on the degree of asthma control in children.

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“…In a recent study by Khoshoo and Haydel Jr [15], 44 children (8-15 years old) with asthma and GERD had a significantly beneficial effect in preventing an exacerbation of asthma after a combination therapy of esomeprazole and metoclopramide. In a Norwegian study of 872 children from 7 to 16 years of age, Stordal et al [16] found that GERD occurred in 19.7% of asthmatic patients, compared with 8.5% of healthy controls. Also in the same study, overweight children had a positive GERD symptom score more frequently than children with normal weight (25.4% vs 16.2%; unadjusted OR, 1.8; 95% CI, 1.2-2.6, P = 0.004) [16].…”

Section: Clinical Manifestations Of Gerd In Children and Adolescentsmentioning

confidence: 97%

Pediatric and adolescent GERD

Yuan

Winter²

2007

Curr GERD Rep

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Asthma and overweight are associated with symptoms of gastro‐oesophageal reflux

Abstract: The prevalence of symptoms associated with gastro-oesophageal reflux was increased in children with asthma and in overweight children. Overweight and asthma were independently associated with GERD symptoms, and overweight did not explain the higher frequency of GERD in asthma patients.

Cited by 40 publications

References 29 publications

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Comorbidities of asthma during childhood: possibly important, yet poorly studied

Pediatric and adolescent GERD

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