Gastroenteropancreatic Peptides and the Central Nervous System

Figlewicz, Dianne P.; Lacour, F.; Sipols, Alfred J.; Porte, D.; Woods, SC

doi:10.1146/annurev.ph.49.030187.002123

Cited by 23 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, it is generally accepted that the cholinergic control of gut Correspondence: Christoph Beglinger MD, Division of Gastroenterology, University Hospital, C H 4 0 3 I Basel, Switzerland. An impressive body of evidence has developed to indicate that CCK can directly act on central and peripheral neurons and that these actions are physiologically important [5]. How can these results be reconciled?…”

Section: Introductionmentioning

confidence: 99%

Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man

Beglinger¹,

Hildebrand²,

Adler

et al. 1992

Eur J Clin Investigation

View full text Add to dashboard Cite

To explore the interactions between cholecystokinin (CCK) and the cholinergic system, we compared the effect of cholinergic or peptidergic CCK blockade on gallbladder contraction and pancreatic enzyme secretion using atropine and loxiglumide (a specific CCK antagonist) as pharmacological tools. Gallbladder contraction was measured by sonography and pancreatic secretion by a marker perfusion and aspiration technique. Graded doses of exogenous CCK8 induced dose-dependent contractions of the gallbladder and increasing enzyme outputs. Loxiglumide (10 mg kg-1 h-1) abolished the gallbladder response and prevented an increase in pancreatic enzyme secretion to CCK8. Atropine (5 micrograms kg-1 h-1), however, only reduced gallbladder contraction and enzyme output to CCK8. Gallbladder volumes decreased maximally to 12 +/- 4% after oral food, whereas enzyme output and plasma CCK levels increased 6- to 8-fold. Loxiglumide completely abolished gallbladder contraction and inhibited enzyme secretion by 30%. Atropine caused a small reduction in gallbladder volumes, but essentially blocked postprandial enzyme secretion. The results indicate that CCK is the major regulator of gallbladder contraction with the cholinergic system modulating the response, while the exocrine pancreas is crucially dependent on a cholinergic background with CCK modulating the secretory response.

show abstract

Section: Introductionmentioning

confidence: 99%

Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man

Beglinger¹,

Hildebrand²,

Adler

et al. 1992

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…In addition, specialized enteroendocrine cells of the gastrointestinal system secrete numerous meal‐associated hormones that are transmitted to the brain neurally via vagal afferents, or humorally as circulating ligands for specific receptor populations in the CNS and periphery. Many of the hormones found in the gastrointestinal tract are also produced in the CNS, 61,65 indicating that either source of the signal can serve as a source of eating‐related signals.…”

Section: From Cells To Glands As Readouts Of Anticipatory Responsesmentioning

confidence: 99%

Oscillators entrained by food and the emergence of anticipatory timing behaviors

Silver

Balsam

2010

Sleep and Biological Rhythms

View full text Add to dashboard Cite

Circadian rhythms are adjusted to the external environment by the light–dark cycle via the suprachiasmatic nucleus, and to the internal environment of the body by multiple cues that derive from feeding/fasting. These cues determine the timing of sleep/wake cycles and all the activities associated with these states. We suggest that numerous sources of temporal information, including hormonal cues such as corticoids, insulin, and ghrelin, as well as conditioned learned responses determined by the temporal relationships between photic and feeding/fasting signals, can determine the timing of regularly recurring circadian responses. We further propose that these temporal signals can act additively to modulate the pattern of daily activity. Based on such reasoning, we describe the rationale and methodology for separating the influences of these diverse sources of temporal information. The evidence indicates that there are individual differences in sensitivity to internal and external signals that vary over circadian time, time since the previous meal, time until the next meal, or with duration of food deprivation. All of these cues are integrated in sites and circuits modulating physiology and behavior. Individuals detect changes in internal and external signals, interpret those changes as “hunger,” and adjust their physiological responses and activity levels accordingly.

show abstract

“…In addition, specialized enteroendocrine cells of the gastrointestinal system secrete numerous meal-associated hormones that are transmitted to the brain neurally via vagal afferents, or humorally as circulating ligands for specific receptor populations in the CNS and periphery. Many of the hormones found in the gastrointestinal tract are also produced in the CNS, 61,65 indicating that either source of the signal can serve as a source of eatingrelated signals.…”

Section: Stomach and Gastrointestinal Tractmentioning

confidence: 99%

Oscillators entrained by food and the emergence of anticipatory timing behaviors

Silver

LeSauter

2010

Appetite

View full text Add to dashboard Cite

Gastroenteropancreatic Peptides and the Central Nervous System

Cited by 23 publications

References 0 publications

Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man

Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man

Oscillators entrained by food and the emergence of anticipatory timing behaviors

Oscillators entrained by food and the emergence of anticipatory timing behaviors

Contact Info

Product

Resources

About