Oscillators entrained by food and the emergence of anticipatory timing behaviors

Silver, Rae; LeSauter, Joseph

doi:10.1016/j.appet.2010.04.186

Cited by 3 publications

(4 citation statements)

References 61 publications

(82 reference statements)

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“…The first is that people with reduced hippocampal function might perceive the interval between two meals as being shorter (i.e., time compression) than a person with an intact hippocampus. However, this consequence may be unlikely to exert much effect on ingestive behavior in humans because of the nearly universal reliance on external frames of reference for routine time keeping (e.g., Silver & Balsam, 2010). Thus, clocks, work, and personal/family routines are likely to be more important in dictating meal times than perceptions of elapsed time.…”

Section: Time Perceptionmentioning

confidence: 99%

The hippocampus and the regulation of human food intake.

Stevenson

Francis

2017

Psychological Bulletin

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Human and animal data suggest that the hippocampus plays certain roles in regulating food intake. However, its actual role may be far broader than currently envisaged, a claim suggested by the centrality of the hippocampus to so many aspects of human/animal cognition. Understanding these ingestion-related functions is especially significant. This is because some degree of hippocampal impairment may be quite common, resulting for example from a Western-style diet, insomnia, diabetes, and depression-among many other causes. One potential consequence of hippocampal impairment could be a loosening of food intake regulation, leading in the longer-term to weight gain and its health-related impacts. Here we review known, suspected and newly hypothesized hippocampal-dependent functions involved in regulating human food intake: (a) declarative memory processes, and their use in explicitly evaluating when, what and how much to eat; (b) interoception, as it relates to hunger, fullness and thirst; (c) inhibitory processes, especially as applied to physiological state, place, and time, and their role in modulating memory retrieval; (d) craving and imagery for food; (e) perception of time and its role in preparing the body for food intake and estimating meal length; (f) trace conditioning and nutrient-related learning; and (g) inhibition of the hypothalamic-pituitary-adrenal stress response and stress-related eating. For each we present evidence for hippocampal involvement, describe the putative regulatory role, and the hypothesized effects of hippocampal impairment. We conclude that the hippocampus is intimately involved in regulating human food intake via multiple interconnected pathways, many of which are unstudied and understudied. (PsycINFO Database Record

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Section: Time Perceptionmentioning

confidence: 99%

The hippocampus and the regulation of human food intake.

Stevenson

Francis

2017

Psychological Bulletin

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Section: Introductionmentioning

confidence: 99%

“…The orexigenic hormone ghrelin acts as an internal signal for animals to engage in food-directed behaviors (Silver and Balsam, 2010;Mason et al, 2014;Al Massadi et al, 2019). It is mainly produced by the stomach oxyntic cells during anticipated mealtimes and its blood levels decrease after meals (Silver and Balsam, 2010). The hypothalamic arcuate nucleus is a major site of expression for ghrelin receptors in the brain, specifically in the cells that synthesize the neuropeptide agouti-related-peptide.…”

Section: Introductionmentioning

confidence: 99%

Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D₁Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin

et al. 2021

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“…Mechanisms have evolved that allow for the temporal regulation of behavior and physiology in time ranges from milliseconds to days (Balsam, Sanchez‐Castillo, Taylor, Van Volkinburg, & Ward, ; Paton & Buonomano, ; Silver & Balsam, ; Silver, Balsam, Butler, & LeSauter, ). Timing behavior in the second‐to‐minutes range, termed interval timing, is essential for the timed anticipation of reward availability (Balsam et al., ) and depends on cortico‐striatal circuits (Emmons et al., ; Gu, Kukreja, & Meck, ; Meck, Penney, & Pouthas, ; Mello, Soares, & Paton, ; Merchant, Harrington, & Meck, ) which are modulated by dopamine (DA).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of striatal D2 receptors reduces motivation thereby decreasing food anticipatory activity

LeSauter

Balsam

Simpson

et al. 2018

Eur J of Neuroscience

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Dopamine has been implicated in circadian timing underlying the food entrainable oscillator (FEO) circuitry and overexpression of the dopamine D2 receptor (D2R) in the striatum has been reported to reduce motivation to obtain food rewards in operant tasks. In the present study, we explored both of these mechanisms by examining food anticipatory activity (FAA) in dopamine D2 receptor‐overexpressing (D2R‐OE) mice under various durations of food availability. First, we noted that at baseline, there were no differences between D2R‐OE mice and their littermates in activity level, food intake, and body weight or in circadian activity. Under conditions of very restricted food availability (4 or 6 hr), both genotypes displayed FAA. In contrast, under 8‐hr food availability, control mice showed FAA, but D2R‐OE mice did not. Normalization of D2R by administration of doxycycline, a tetracycline analogue, rescued FAA under 8‐hr restricted food. We next tested for circadian regulation of FAA. When given ad libitum access to food, neither D2R‐OE nor controls were active during the daytime. However, after an interval of food restriction, all mice showed elevated locomotor activity at the time of previous food availability in the day, indicating circadian timing of anticipatory activity. In summary, motivation is reduced in D2R‐OE mice but circadian timing behavior is not affected. We conclude that an increase in striatal D2R reduces FAA by modulating motivation and not by acting on a clock mechanism.

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Oscillators entrained by food and the emergence of anticipatory timing behaviors

Cited by 3 publications

References 61 publications

The hippocampus and the regulation of human food intake.

The hippocampus and the regulation of human food intake.

Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D₁Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin

Overexpression of striatal D2 receptors reduces motivation thereby decreasing food anticipatory activity

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Oscillators entrained by food and the emergence of anticipatory timing behaviors

Cited by 3 publications

References 61 publications

The hippocampus and the regulation of human food intake.

The hippocampus and the regulation of human food intake.

Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin

Overexpression of striatal D2 receptors reduces motivation thereby decreasing food anticipatory activity

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Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D₁Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin