Gastroenteropancreatic neuroendocrine tumors: Incidence and treatment outcome in a single institution in Korea

Lim, Taekyu; Lee, Jeeyun; Kim, Jae J.; Lee, Jong Kyun; Lee, Kyu Taek; Kim, Young Ho; Kim, Kwang Won; Kim, Sung Hoon; Sohn, Tae Sung; Choi, Dong Wook; Choi, Seong Ho; Chun, Ho Kyung; Lee, Woo Young; Kim, Kyoung Mee; Jang, Kee Taek; Park, Young Suk

doi:10.1111/j.1743-7563.2011.01423.x

Cited by 26 publications

(45 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common were NENG1 by WHO 2010 (64% of cases), which is consistent with other studies [11][12][13]. NENG1 predominated among appendiceal, rectal, gastric, and small intestinal NEN.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Epidemiologia nowotworów neuroendokrynnych układu pokarmowego w Krakowie i powiecie krakowskim w latach 2007-2011.

Trofimiuk–Müldner

Lewkowicz

Wysocka

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

“…12.2011, living in Krakow or Krakow district, were identified. 75% of them were followed in the Endocrinology Department of University Hospital in Krakow.…”

Section: Methodsmentioning

confidence: 99%

Epidemiologia nowotworów neuroendokrynnych układu pokarmowego w Krakowie i powiecie krakowskim w latach 2007-2011.

Trofimiuk–Müldner

Lewkowicz

Wysocka

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

“…However, the jejunum/ileum accounted for no more than 3% of tumors, and the colon was the least frequent tumor site in our study. A similar distribution of NENs was also found in other two Asian populations (Lim et al, 2011;Wang et al, 2012), but tumor distribution is different in the non-Asian Races. The rectum and jejunum/ileum were the most common sites for NENs in the SEER Program tumor registry from the United States in North America, and pancreatic NENs were only the third most common site for NENs .…”

Section: Discussionsupporting

confidence: 81%

“…Our data show that the incidence of GEP-NENs has risen over the last 12 years, as has been reported in previous studies (Konishi et al, 2007;Ploeckinger et al, 2009;Garcia-Carbonero et al, 2010;Estrozi et al, 2011;Lim et al, 2011). In this study, we investigated the pathologic features of GEP-NENs using the latest histopathologic diagnosis consensus and analyzed overall survival by Univariate analysis and Cox proportional hazards regression modeling.…”

Section: Discussionsupporting

confidence: 76%

Clinicopathological Features and Prognosis of Gastroenteropancreatic Neuroendocrine Tumors: Analysis from a Single-institution

Zeng

Liu²,

Wu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine neoplasm. We summarized data in our centre to investigate the clinicopathological features, diagnostic methods, therapeutic approaches and prognosis for this neoplasm to increase knowledge of this disease in Asian populations. Method: A total of 122 patients treated at Sun Yet-san Memorial Hospital of Sun Yat-sen University between January 2000 and December 2011 were analyzed retrospectively. Results: Pancreas was the most common site of involvement (65/122, 53.3%); this disease has no special symptoms; positive rates of chromogranin A (CgA) and synaptophysin (Syn) were 81.1% and 87.7%, respectively. The positive rate of Syn had statistical difference among the three grades, but not CgA. Some 68 patients had G1 tumors, 32 G2 tumors and 22 G3 tumors, and Chi-square test showed that higher grading was correlated with worse prognosis (χ 2 =32.825, P=0.0001). A total of 32 patients presented with distant metastasis, and 8 cases emerged during following up. Cox proportional hazards regression modeling showed that the tumor grade (P=0.01), lymphatic metastasis (P=0.025) and distant metastasis (P=0.031) were predictors of unfavorable prognosis. The overall 5-year survival rate was 39.6%, the 5-year survival rate of G1 was 55.7%, and the G2 and G3 were 34.2% and 0%, respectively.Conclusions: The incidence of gastroenteropancreatic neuroendocrine tumors has risen over the last 12 years. All grades of these diseases metastasize readily, and further research regarding the treatment of patients after radical surgery is needed to prolong disease-free survival.

show abstract

“…In Western nations, 30-60 % of GEP-NETs are derived from midgut [2,13,14] in contrast to the Japanese data. The epidemiology of GEP-NETs was recently reported in Asian nations including Taiwan [15], China [16], and Korea [17,18]. Interestingly, the prevalence of patients with midgut NETs in these nations is low like Japan, indicating ethnic differences between Asians and Western populations.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis

et al. 2014

View full text Add to dashboard Cite

Background Although neuroendocrine tumors (NETs) are rare, the number of patients with NET is increasing. However, in Japan, there have been no epidemiological studies on NET since 2005; thus, the prevalence of NET remains unknown. Methods We reported the epidemiology of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) [pancreatic neuroendocrine tumors (PNETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005. Here, we conducted the second nationwide survey on patients with GEP-NETs who received treatment in 2010. Results A total of 3,379 patients received treatment for PNETs in 2010, representing a 1.2-fold increase in the number of patients from 2005 to 2010. The prevalence was estimated to be 2.69/100,000, with an annual onset incidence of 1.27/100,000 in 2010. Non-functioning tumor (NF)-PNETs comprised 65.5 % of cases followed by insulinoma (20.9 %) and gastrinoma (8.2 %). Interestingly, the number of patients with NF-PNETs increased *1.8 fold since 2005. A total of 19.9 % of patients exhibited distant metastasis at initial diagnosis; 4.3 % had complications with multiple endocrine neoplasia type 1 (MEN-1), and only 4.0 % had NF-PNETs associated with MEN-1. Meanwhile, an estimated 8,088 patients received treatment for GI-NETs, representing a *1.8-fold increase since 2005. The prevalence was estimated to be 6.42/100,000, with an annual onset incidence of 3.51/100,000. The locations of GI-NETs varied: foregut, 26.1 %; midgut, 3.6 %; and hindgut, 70.3 %. Distant metastasis and complications with MEN-1 were observed in 6.0 and 0.42 % at initial diagnosis, respectively. The frequency of carcinoid syndrome in patients with GI-NETs was 3.2 %. Conclusion We clarified the epidemiological changes in GEP-NETs from 2005 to 2010 in Japan.

show abstract

Gastroenteropancreatic neuroendocrine tumors: Incidence and treatment outcome in a single institution in Korea

Cited by 26 publications

References 29 publications

Epidemiologia nowotworów neuroendokrynnych układu pokarmowego w Krakowie i powiecie krakowskim w latach 2007-2011.

Epidemiologia nowotworów neuroendokrynnych układu pokarmowego w Krakowie i powiecie krakowskim w latach 2007-2011.

Clinicopathological Features and Prognosis of Gastroenteropancreatic Neuroendocrine Tumors: Analysis from a Single-institution

Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis

Contact Info

Product

Resources

About