Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation

Wang, Xiaoliang; Chen, Lihai; Xu, Yajie; Wang, Wanling; Wang, Youran; Zhang, Zhi Yuan; Zheng, Jing; Bao, Huihui

doi:10.1016/j.ejphar.2020.173734

Cited by 21 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastrodin can reduce the levels of inflammatory cytokines TNF- α , IL-1 β , and IL-6 and increase the anti-inflammatory factor IL-10 ( Figure 3 ). Gastrodin can also regulate Mir-21-5p and Mir-331-5p to prevent the inflammatory activation caused by ischemia, thus playing a neuroprotective role [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the above pathways, gastrodin treatment significantly preserves the Wnt/ β -catenin signaling pathway in neurons, reduces the activation of cox-2 downstream, promotes neurogenesis, and provides neuroprotection against brain injury [ 100 ]. However, gastrodin inhibited the phosphorylation of glycogen synthase kinase-3 β (GSK-3 β ) and β -catenin induced by lipopolysaccharide in microglia and modulated anti-inflammatory and antiproliferation effects in active microglia [ 57 , 101 ] ( Figure 4(a) ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is the dementia syndrome with the largest number of patients besides Alzheimer’s disease. Although there is still a lack of evidence-based explorations, the paper reviewed the mechanism and methods of gastrodin in the treatment of vascular dementia, providing a reference for clinical therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Gastrodia elata is a commonly used traditional Chinese medicine with various pharmacological effects. The antiaging functions of bioactive ingredients in Gastrodia elata, such as gastrodin, have been widely reported in terms of life extension, neuroprotection, antiinflammation and antioxidation ( Chen et al, 2021 ; He et al, 2021 ; Wang et al, 2021 ). However, most studies focus on the therapeutic effects of these bioactive ingredients on aging-related diseases, therefore, animal models with artificially induced pathological damage are often used.…”

Section: Discussionmentioning

confidence: 99%

Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner

et al. 2022

View full text Add to dashboard Cite

The physiological and pathological processes that accompany aging can seriously affect the quality of life of the elderly population. Therefore, delaying aging and developing antiaging products have become popular areas of inquiry. Gut microbiota plays an important role in age-related phenotypes. The present study aimed to investigate the antiaging effects and underlying mechanism of parishin, a phenolic glucoside isolated from traditional Chinese medicine Gastrodia elata. Samples from adult (12 weeks), low-dose (10 mg/kg/d) or high-dose (20 mg/kg/d) parishin-treated and untreated aged (19 months) mice were collected to determine blood indicators, gut microbiota and metabolome, and cardiopulmonary histopathological features. The results showed that parishin treatment ameliorates aging-induced cardiopulmonary fibrosis and increase in serum p16Ink4a, GDF15, and IL-6 levels. Furthermore, parishin treatment alleviated dysbiosis in gut microbiota, including altered microbial diversity and the aberrant abundance of opportunistic pathogenic bacteria such as Turicibacter and Erysipelatoclostridium. Gene function prediction and gut metabolome analysis results indicated that the parishin treatment-altered gut microbiota played important roles in sugar, lipid, amino acid and nucleic acid metabolism, and improved gut metabolic disorders in aged mice. In conclusion, the present study provides an experimental basis of potential applications of parishin against aging.

show abstract

“…Excess inflammatory cytokines could influence the turnover of monoamine neurotransmitters and induce various neuropsychiatric disorders [ 53 ]. Inflammation has been implicated as a trigger of ADHD [ 54 ], and gastrodin has been proved to have anti-inflammatory pharmacological effects, which can alleviate cognitive impairment by lessening TNF- α and IL-6 levels [ 18 ]. KCNJ3, also termed GIRK1 or Kir3.1, is extensively expressed in the central nervous system and binds to three other potassium channel proteins (i.e., KCNJ6/GIRK2, KCNJ9/GIRK3, and KCNJ5/GIRK4) to form the G protein-gated inwardly rectifying potassium (GIRK) channel [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Gastrodin, chemically known as 4-hydroxymethylphenyl β -D-glucopyranoside, is the key characteristic medicinal component of G. elata [ 16 ]. Modern pharmacological studies have revealed that gastrodin has the properties of the regulation of monoamine neurotransmitters [ 17 ], anti-inflammation [ 18 ], antioxidation [ 19 ], antianxiety [ 20 ], neuron protection [ 21 ], etc., closely related to the known ADHD pathogenesis. Moreover, gastrodin exhibits excellent oral bioavailability, rapid penetration of the blood-brain barrier, and almost nontoxicity [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Targets and Action Mechanism of Gastrodin in the Treatment of Attention-Deficit/Hyperactivity Disorder: Bioinformatics and Network Pharmacology Analysis

Song

Luo

Han

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Gastrodin is a main medicinal component of traditional Chinese medicine (TCM) Gastrodia elata Blume (G. elata), presenting the potential for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, the underlying targets and action mechanisms of the treatment have not been identified. Methods. The gastrodin-related microarray dataset GSE85871 was obtained from the GEO database and analyzed by GEO2R to obtain differentially expressed genes (DEGs). Subsequently, the targets of gastrodin were supplemented by the Encyclopedia of Traditional Chinese Medicine (ETCM), PubChem, STITCH, and SwissTargetPrediction databases. ADHD-associated genes were collected from six available disease databases (i.e., TTD, DrugBank, OMIM, PharmGKB, GAD, and KEGG DISEASE). The potential targets of gastrodin during ADHD treatment were obtained by mapping gastrodin-related targets with ADHD genes, and their protein–protein interaction (PPI) relationship was constructed by the STRING database. The GO function and KEGG pathway enrichment analyses were performed using the ClueGO plug-in in the Cytoscape software and DAVID database, respectively. Finally, the binding affinity between gastrodin and important targets was verified by molecular docking. Results. A total of 460 gastrodin-related DEGs were identified from GSE85871, and 124 known gastrodin targets were supplemented from 4 databases, including ETCM. A total of 440 genes were collected from the above 6 disease databases, and 267 ADHD-relevant genes were obtained after duplicate removal. Through mapping the 584 gastrodin targets to the 267 ADHD genes, 16 potential therapeutic targets were obtained, among which the important ones were DRD2, DRD4, CHRNA3, CYP1A1, TNF, IL6, and KCNJ3. The enrichment analysis results indicated that 16 potential targets were involved in 25 biological processes (e.g., dopamine (DA) transport) and 22 molecular functions (e.g., postsynaptic neurotransmitter receptor activity), which were mainly localized at excitatory synapses. The neuroactive ligand-receptor interaction, cholinergic synapse, and dopaminergic synapse might be the core pathways of gastrodin in ADHD treatment. Through molecular docking, it was preliminarily verified that gastrodin showed good binding activity to seven important targets and formed stable binding conformations. Conclusions. Gastrodin might exert an anti-ADHD effect by upgrading the dopaminergic system and central cholinergic system, inhibiting the inflammatory response and GIRK channel, and exerting a synergistic effect with other drugs on ADHD. For this reason, gastrodin should be considered a multitarget drug for ADHD treatment.

show abstract

Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation

Cited by 21 publications

References 39 publications

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner

Potential Targets and Action Mechanism of Gastrodin in the Treatment of Attention-Deficit/Hyperactivity Disorder: Bioinformatics and Network Pharmacology Analysis

Contact Info

Product

Resources

About