Gastro-oesophageal reflux disease and irritable bowel syndrome significantly associated with metabolic syndrome

Pipili, Chrysoula; Dasenaki, Maria

doi:10.1080/00365520802308029

Cited by 9 publications

(14 citation statements)

References 4 publications

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“…This result is consistent with previous studies about metabolic syndrome and GERD or erosive esophagitis [12,27,28]; however, a Japanese study did not find such an association between elevated serum TG and erosive esophagitis [13]. It has been reported that hypertriglyceridemia is associated with increased insulin resistance [29] and chronic Helicobacter pylori infections which was suggested to be a protective factor for erosive esophagitis can modify the serum lipid profile [30,31].…”

Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort

et al. 2012

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BackgroundData about prevalence of gastroesophageal reflux diseases (GERD) from Asian populations are still scarce. To provide additional data on prevalence of GERD and investigate its potential risk factors, we performed this cross-sectional study in the Taizhou Retiree Cohort.MethodsAfter physical examination, the participants were asked whether they suffered with heartburn or acid regurgitation in the last 12 months by trained interviewers, and if yes, the severity and frequency of the symptoms were recorded. Odds ratios (ORs) with 95% confidence intervals (CIs) for the associations of obesity and other risk factors with GERD were derived from logistic regression models.Results8831 retirees completed the questionnaire and physical examination. In total 150 (1.7%) reported the symptoms occurring at least once per week within the last 12 months before the interview. Compared with subjects without GERD, having a history of diabetes mellitus (OR 2.2, 95% CI 1.4-3.5), hypertension (OR 1.4, 95% CI 1.0-2.1), gastritis (OR 8.2, 95% CI 5.8-11.5), peptic ulcer (OR 3.3, 95% CI 1.8-6.1) and high triglyceride level (≥1.81mmol/L) (OR 2.0, 95% CI 1.2-3.4) were associated with a significantly increased risk of GERD. However, there was no significant association between body mass index, waist-to-hip ratio or waist alone, smoking, consumption of alcohol & tea, and the occurrence of reflux symptoms.ConclusionsCompared with Western populations, the prevalence of GERD in this Chinese retiree cohort is low. A history of diabetes mellitus, hypertension, gastritis, peptic ulcer or hypertriglyceridaemia increases GERD risk in this population.

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Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort

et al. 2012

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“…High TG levels were also a risk factor associated with CL in this study. Several studies have revealed that a high level of serum TG is an important predictive factor for GERD or erosive esophagitis among the components of metabolic syndrome [ 29 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Obesity and Chronic Laryngitis in Women - Data from the Korea National Health and Nutrition Examination Survey

Joo

Han²,

Lee³

2015

Obes Facts

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Background: This study aimed to investigate the relationship between obesity and chronic laryngitis in South Korea using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) collected during 2008-2010. Methods: KNHANES was a cross-sectional survey of the civilian, non-institutionalized population of South Korea (n = 13,819). Obesity status was measured by using BMI and waist circumference. Results: Among the population over 19 years of age, the prevalence of chronic laryngitis was 4.0 ± 0.4%. Chronic laryngitis was significantly associated with age, BMI, waist circumference, fat proportion, both systolic and diastolic blood pressure, fasting blood sugar, triglycerides, and high-density lipoprotein cholesterol in women. Old age and current smoking were significantly associated with chronic laryngitis in men. Obese women were at a higher risk for chronic laryngitis than women without obesity (odds ratio (OR) 2.022, 95% confidence interval (95% CI) 1.412-2.895) after further adjustment for confounders. Women with abdominal obesity were also at higher risk for chronic laryngitis (OR 1.475, 95% CI 1.024-2.126). Conclusion: Obese women in Korea have an elevated risk for developing chronic laryngitis. Further epidemiological and experimental studies are necessary to clarify the impact of obesity on this condition.

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“…Many studies of the relationship between obesity and several gastrointestinal diseases have been performed, however, we know visceral obesity is the core of MS, and MS can be supposed to be associated with gastrointestinal diseases. For example, that irritable bowel syndrome was significantly associated with MS 20 . In recent years, several studies have shown that obesity especially abdominal obesity was an important independent risk factor for RE 13,21–25 .…”

Section: Discussionmentioning

confidence: 99%

The association of metabolic syndrome with reflux esophagitis: a case-control study

Livzan

Dai

et al. 2011

Neurogastroenterology &Amp; Motility

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Gastro-oesophageal reflux disease and irritable bowel syndrome significantly associated with metabolic syndrome

Cited by 9 publications

References 4 publications

Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort

Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort

Association between Obesity and Chronic Laryngitis in Women - Data from the Korea National Health and Nutrition Examination Survey

The association of metabolic syndrome with reflux esophagitis: a case-control study

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