The association of metabolic syndrome with reflux esophagitis: a case-control study

Wu, Peng; Livzan, M. А.; Dai, Guowei; Chen, Y.; Tong, Yili; Wang, Congyan; Yao, Lin; Jiang, Yilin; Xu, Shuchang; Ai, Zisheng

doi:10.1111/j.1365-2982.2011.01786.x

Cited by 23 publications

(38 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the sarcopenia-associated loss of skeletal muscle mass and gain of visceral adiposity were positively associated with blood pressure, triglyceride levels, hyperglycemia, and a number of other metabolic syndrome components [14,28,29]. Strong evidence also supports the association of metabolic syndrome with RE [31,32]. Our study also revealed that metabolic components, such as systolic blood pressure, fasting blood glucose levels, and triglyceride levels, were independent risk factors for erosive esophagitis.…”

Section: Discussionsupporting

confidence: 70%

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Kim¹,

Pyo²,

Lee³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

Backgrounds: Obesity is an established risk factor for erosive esophagitis. Yet, the associations of sarcopenia and obesity with erosive esophagitis remain unclear. We studied the associations of obesity, sarcopenia, and sarcopenic obesity with the risk of erosive esophagitis in a large number of asymptomatic men and women. Materials and Methods: We conducted a cross-sectional study of 32,762 asymptomatic adults undergoing routine health checkups including screening endoscopy, between August 2006 and December 2011. Sarcopenia was defined as an appendicular skeletal muscle mass (ASM) /body weight value beyond two standard deviations below the mean for healthy young adults. The ASM was estimated using bioelectrical impedance analysis. Results: Participants were categorized into four groups according to their obesity and sarcopenic status: normal, obese, sarcopenic, and sarcopenic obese. In a multivariable model adjusted for age, sex, smoking status, alcohol intake, regular exercise, and metabolic variables, the risk of erosive esophagitis was higher in obese [adjusted odds ratio(aOR), 1.38; 95% confidence interval (CI), 1.26-1.52], sarcopenic (aOR, 2.20; 95% CI, 1.48-3.29), and sarcopenic obese participants (aOR, 1.68; 95% CI, 1.39-2.03) than in normal participants. Comparing sarcopenic and sarcopenic obese participants to obese participants, the ORs for erosive esophagitis were 1.59 (95% CI, 1.06-2.38) and 1.22 (95% CI, 1.02-1.47), respectively. In dose-response analyses, increasing sarcopenia severity showed a positive and graded relationship with overall, LAB or higher grade, and LA-C erosive esophagitis. Conclusions: Our findings suggest that sarcopenia, regardless of obesity status, is strongly and progressively associated with the risk of erosive esophagitis. IntroductIon Gastroesophageal reflux disease is a widespread gastrointestinal disorder that frequently occurs in primary care settings, imposing considerable burdens on global health and economics [1]. Disease prevalence is 18.1-27.8% in North America, 8.8-25.9% in Europe, and 2.5-7.8% in East Asia, with rising rates worldwide [2]. Obesity is considered a significant contributing factor for a spectrum of reflux-related esophageal disorders ranging from

show abstract

Section: Discussionsupporting

confidence: 70%

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Kim¹,

Pyo²,

Lee³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Eight studies used visceral adipose tissue area as measure of central adiposity (4 each in patients with EE 12,28,29,34 and BE 16,44,46,53 ), 23 studies used WHR (7 studies on EE, 30,34–37,39,40 11 studies on BE, 9–11,13,35,48–52,54 and 5 studies on EAC 13,56–59 ). The characteristics of the included studies for each outcome are shown in Tables 1–3.…”

Section: Resultsmentioning

confidence: 99%

Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis

Singh

Sharma

Murad

et al. 2013

Clinical Gastroenterology and Hepatology

302

232

View full text Add to dashboard Cite

BACKGROUND & AIMS Central adiposity has been implicated as a risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), possibly promoting the progression from inflammation to metaplasia and neoplasia. We performed a systematic review and meta-analysis of studies to evaluate the association between central adiposity and erosive esophagitis (EE), BE, and EAC, specifically exploring body mass index (BMI)–independent and gastroesophageal reflux (GERD)–independent effects of central adiposity on the risk of these outcomes. METHODS We performed a systematic search of multiple databases through March 2013. Studies were included if they reported effect of central adiposity (visceral adipose tissue area, waist-hip ratio, and/or waist circumference) on the risk of EE, BE, and EAC. Summary adjusted odds ratio (aOR) estimates with 95% confidence intervals (CIs), comparing highest category of adiposity with the lowest category of adiposity, were calculated by using randomeffects model. RESULTS Forty relevant articles were identified. Compared with patients with normal body habitus, patients with central adiposity had a higher risk of EE (19 studies; aOR, 1.87; 95% CI, 1.51–2.31) and BE (17 studies; aOR, 1.98; 95% CI, 1.52–2.57). The association between central adiposity and BE persisted after adjusting for BMI (5 studies; aOR, 1.88; 95% CI, 1.20–2.95). Refluxindependent association of central adiposity and BE was observed in studies that used GERD patients as controls or adjusted for GERD symptoms (11 studies; aOR, 2.04; 95% CI, 1.44–2.90). In 6 studies, central adiposity was associated with higher risk of EAC (aOR, 2.51; 95% CI, 1.54–4.06), compared with normal body habitus. CONCLUSIONS On the basis of a meta-analysis, central adiposity, independent of BMI, is associated with esophageal inflammation (EE), metaplasia (BE), and neoplasia (EAC). Its effects are mediated by reflux-dependent and reflux-independent mechanisms.

show abstract

“…Intraduodenal administration of long-chain TG after meals affects the functions of the lower esophageal sphincter such as contraction and relaxation [29,30], and cholesterol of dietary nutrients enhances perception of the esophagus after intraesophageal acid reflux [31]. Serum TG levels are associated with non-erosive GERD [32] and erosive GERD [5,33] mediated via these mechanism(s). Thus, serum TG and T-CHO as characteristics of NAFLD but not abdominal mechanical pressure caused by visceral obesity might be involved in GERD symptoms in patients with NAFLD.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Gastroesophageal Reflux Symptoms in Patients with Non-Alcoholic Fatty Liver Disease Associated with Serum Levels of Triglyceride and Cholesterol but Not Simple Visceral Obesity

Fujikawa

Tominaga²,

Fujii³

et al. 2012

Digestion

View full text Add to dashboard Cite

Background/Aims: Visceral obesity is commonly involved in the pathogenesis of gastroesophageal reflux disease (GERD) and non-alcoholic fatty liver disease (NAFLD). However, other characteristic factors different from visceral obesity are associated with the pathogenesis of NAFLD. We investigated the prevalence of GERD symptoms in patients with NAFLD and its associated risk factors. Methods: NAFLD (n = 96) and controls (n = 139) were enrolled in this study. GERD symptoms were evaluated by using a frequency scale for the symptoms of GERD. Results: GERD symptom score and its prevalence rate were higher in the NAFLD group (7.4 ± 0.7, 37%) than those seen in the control groups (4.5 ± 0.4, 20%), which was independent of sex, age, and body mass index (BMI). GERD symptoms were correlated with insulin resistance (r = 0.167, p = 0.011), total cholesterol (T-CHO) (r = 0.138, p = 0.034), triglyceride (TG) (r = 0.178, p = 0.006), or immunoreactive insulin (r = 0.173, p = 0.008) but not BMI (r = 0.089, p = 0.175). GERD symptoms of the NAFLD group were significantly severer in the higher group of T-CHO and TG levels than those in the lower group. Multivariate analysis proved that risk factors related to GERD symptoms were TG (OR 3.96, 95% CI 1.31–11.9) and T-CHO (OR 3.39, 95% CI 1.11–10.3). Conclusion: The severity and prevalence of GERD symptoms in patients with NAFLD were high, which was associated with serum levels of TG and T-CHO but not BMI.

show abstract

The association of metabolic syndrome with reflux esophagitis: a case-control study

Abstract: High waist hip ratio, triglyceride, fasting blood glucose, and metabolic syndrome were associated with increased risk factors for reflux esophagitis while high high-density lipoprotein for men correlated with a reduced risk of reflux esophagitis.

Cited by 23 publications

References 28 publications

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis

High Prevalence of Gastroesophageal Reflux Symptoms in Patients with Non-Alcoholic Fatty Liver Disease Associated with Serum Levels of Triglyceride and Cholesterol but Not Simple Visceral Obesity

Contact Info

Product

Resources

About