Gastro-intestinal manifestations of the initial phase of schistosomiasis mansoni

Rocha, Manoel Otávio Costa; Pedroso, Ênio Roberto Pietra; Lambertucci, José Roberto; Greco, Dirceu Bartolomeu; Rocha, Regina Lunardi; Rezende, Dilermando Fazito de; Neves, Jorge Tadeu de Ramos

doi:10.1080/00034983.1995.11812952

Cited by 21 publications

(13 citation statements)

References 10 publications

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“…After infection by larvae of S. mansoni , adult worms are eventually located in the mesenteric vessel bed and parasite eggs get entrapped in the portal and mesenteric venous systems. A granulomatous inflammatory response is induced, resulting in fibrosis of the liver and the intestinal wall 23 . Due to the temporal and spatial recruitment of differential mast cell subsets in the acutely and chronically S. mansoni ‐infected murine ileum, the S. mansoni ‐infected mouse represents a useful model to investigate the interaction between extrinsic/intrinsic neurons and different mast cell subtypes 24 …”

Section: Introductionmentioning

confidence: 99%

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹

Bosch

Nassauw

Lantermann

et al. 2007

Neurogastroenterology Motil

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Despite our knowledge of somatostatin (SOM) in gastrointestinal functions, little information is available on the SOM receptors (SSTRs) mediating these effects. This study focussed on the expression of SSTRs in non-inflamed and Schistosoma mansoni-infected murine ileum using immunocytochemistry, reverse transcriptase (RT)-PCR and quantitative real time RT-PCR (qPCR). In the non-inflamed ileum, SSTRs showed a widespread, cell-type specific expression pattern. For instance, SSTR2A immunoreactivity was detected in a minor population of submucous but not myenteric glial cells. In the inflamed ileum, significant changes in the expression pattern of SSTRs occurred, with SSTR1 and SSTR3 expression on mucosal mast cells (MMCs) and mucosal nerve fibres. SSTR4-immunoreactive nerve fibres were detected in granulomas and the lamina propria. qPCR experiments indicated significantly increased mRNA levels for SOM, SSTR1 and SSTR3 in inflamed ileum. This study reveals that SSTRs are expressed in specific cell types in murine ileum. Expression of SSTR1 and SSTR3 on MMCs and increased density of SOM-expressing nerve fibres in the lamina propria during inflammation, support the hypothesis that SOM is implicated in the physiological control of MMCs during intestinal inflammation. Evidence is provided that in mouse mainly SSTR1, SSTR3 and SSTR4 are involved in the somatostatinergic inflammatory effects during intestinal schistosomiasis.

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Section: Introductionmentioning

confidence: 99%

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹

Bosch

Nassauw

Lantermann

et al. 2007

Neurogastroenterology Motil

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“…An important proportion of the eggs, however, actively migrates through the bowel wall to enter the lumen and complete the parasite’s life cycle. Eighty‐five percent of the infected individuals suffer from motility‐related gastrointestinal symptoms such as diarrhoea, anorexia, nausea and abdominal cramps 6 . Morbidity is related to the severity of the infection, mild cases (less than 100 eggs g −1 of faeces) can be asymptomatic 1 .…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Bogers

Moreels

Man

et al. 2000

Neurogastroenterology Motil

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Schistosomiasis mansoni is a major health problem, mainly occurring in developing countries. A large proportion of infected individuals suffers from motility-related gastrointestinal problems. In the present study, the diffuse inflammatory response in the small bowel wall, as compared to the egg-induced granulomatous inflammation, was investigated. For this purpose, OF1 mice infected with Schistosoma mansoni 8-16 weeks prior to the experiment, and uninfected control mice were studied. The ileum showed both a diffuse mucosal inflammation as well as a granulomatous reaction. The diffuse mucosal inflammation caused an increase in the thickness of the mucosa, with blunting of the villi. A significant, transient increase of thickness of the muscularis propria after 12 weeks of infection was noted. There was an infection-related mast cell infiltrate in the muscularis propria, consisting of formalin fixation-insensitive connective tissue mast cells. Ganglionitis of the myenteric plexus was noted. Rarely, ganglia of the myenteric plexus contained apoptotic cells. A general pharmacological set of experiments showed a significant increase in intestinal contractility, both to exogenously administered, as well as to endogenously released neurotransmitters. Our results demonstrate that S. mansoni infection in the mouse ileum leads to diffuse specific enteric inflammation that is associated with an enhanced response to contractile agents.

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“…Acute symptoms are often nonspecific and can include bloody mucoid diarrhea, tenesmus, abdominal pain, bowel obstruction, fever, and weight loss [48]. The differential diagnosis is broad (Table 2).…”

Section: Intestinal Schistosomiasismentioning

confidence: 98%

Gastrointestinal complications of schistosomiasis

Schafer

Hale²

2001

Curr Gastroenterol Rep

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Schistosomiasis is an important disease in many parts of the world and has affected the course of human history many times over. The parasitic infection is acquired during contact with infected water. A chronic inflammatory response to schistosome eggs, mediated by both cellular and humoral mechanisms, is the root of the pathology seen in schistosomiasis. Hepatosplenic disease results in intrahepatic presinusoidal portal hypertension. The resultant esophageal and gastric varices are an important cause of morbidity and mortality. Standard treatment guidelines for managing varices can be applied to patients with schistosomiasis. Coinfection with viral hepatitis results in liver disease that progresses more rapidly and is more difficult to treat. Intestinal schistosomiasis may be confused with other disease states and can be an important cause of morbidity, especially in heavily infected patients. Diagnosis relies on demonstration of schistosome eggs in feces or tissue. Praziquantel is the treatment of choice. The development of a vaccine for schistosomiasis is an important goal in the attempt to control this disease.

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Gastro-intestinal manifestations of the initial phase of schistosomiasis mansoni

Cited by 21 publications

References 10 publications

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Gastrointestinal complications of schistosomiasis

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Gastro-intestinal manifestations of the initial phase of schistosomiasis mansoni

Cited by 21 publications

References 10 publications

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum1

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum1

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Gastrointestinal complications of schistosomiasis

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Product

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Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹

Effect of intestinal inflammation on the cell‐specific expression of somatostatin receptor subtypes in the murine ileum¹