Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Baştürk, Ahmet; Artan, Reha; Yılmaz, Aygen; Gelen, Mustafa Tekinalp

doi:10.5223/pghn.2018.21.3.163

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…Of these, 7.1% are peritonitis, 2.4% are gastritis, 1.7% are UC, 0.7% are villous atrophy and COPD. These results are similar to those of 19,20 . We also found 0.3% cases of meningitis and 01% of appendicitis in the under 20 age group with a significant rate.…”

supporting

confidence: 89%

Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

Benaissa

Kanoun

Zemri

et al. 2020

J. Drug Delivery Ther.

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Background: Crohn's disease is a chronic and recurrent inflammatory bowel disease that progresses slowly. Also CD patients have a large number of extra-intestinal manifestations. Objective: we sought to define the possible associations between inflammatory pathology and localization and on the other hand, inflammatory pathologies and the disease behavior Methods: A retrospective analytical study was carried out at the level of gastric and general surgery services of Western Algerian University Hospital of Sidi Bel Abbes region, during the period 2007-2019. Results Our study was based on a total sample of 295 cases involving 114 females (38.6%) and 181 males (61.4%) with a sex ratio of (1.58). The location of the disease at the time of diagnosis was dominated by the ileo-caecal location (55.3%), of which 64.4% were associated with inflammatory pathology (IP). The majority of patients diagnosed with Crohn's disease had an inflammatory behavior and this for all age groups. The appendix, the ulcer and inflammatory anemia are most associated with Crohn’s disease. For inflammatory extra-intestinal manifestations, only group of patients with arthralgia had significantly higher rates in the 20-60 age groups. The mainly noted risk factors were appendectomy with (17.3%), smoking (22.4%) with a highly significant association, and alcoholism (6.1%). Conclusion According to our results the association of inflammatory pathology and crohn disease is more frequent in male and dominated by arthralgia as extra-intestinal manifestations lesions. Keywords: Crohn disease; Inflammatory pathology; disease behavior; inflammatory extra-intestinal manifestation.

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supporting

confidence: 89%

Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

Benaissa

Kanoun

Zemri

et al. 2020

J. Drug Delivery Ther.

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“…One explanation for the temporal change from H pylori‐ positive to H pylori ‐negative in the distribution of pediatric gastritides reflected in the aforementioned studies could be the rising prevalence of pediatric IBD (31–33) and celiac disease (34–36), in which HPNCG is known to be a common finding (5–7,37–39). We found both forms of HPNCG were associated with Crohn disease and the inactive form was also associated with celiac disease and ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Significance of Helicobacter Pylori‐negative Chronic Gastritis in Children

Virkkula

Kivelä

Hiltunen

et al. 2022

J. pediatr. gastroenterol. nutr.

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Objectives: The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling. Methods: Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected. Baseline characteristics and long-term outcomes were compared between children with active and inactive HPNCG and those with normal gastric histology. Follow-up data were available for up to 13 years. Results: Altogether 24 (2.0%) children had active and 235 (19.9%) inactive HPNCG, 27 (2.3%) were Hpylori-positive, 46 (3.9%) had other gastric pathology, and 846 (71.8%) normal histology. Diarrhea (31.3% vs 25.1%, P ¼ 0.033), poor growth (23.6% vs 14.7%, P < 0.001), bloody stools (13.9% vs 7.2%, P < 0.001), anemia (46.5% vs 23.4%, P < 0.001), hypersedimentation (39.7% vs 21.4%, P < 0.001), hypoalbuminemia (40.4% vs 16.2%, P < 0.001), and elevated fecal calprotectin (62.4% vs 31.5%, P < 0.001) were more common and heartburn (13.9% vs 22.9%, P ¼ 0.002) less common in the HPNCG group than in the controls. Both active (OR 3.64,95% CI 1.35-9.82) andinactive (2.98, 2.18-4.08) HPNCG predicted a diagnosis in the initial investigations. Crohn disease (41.7%) was the most common diagnosis in active HPNCG and celiac disease (37.4%) in inactive HPNCG. During follow-up, 7 (9.9%) of the 71 initially nondiagnosed HPNCG children received a diagnosis. Conclusions: HPNCG is a frequent finding in children undergoing EGD, the active form being associated especially with Crohn disease and the inactive with celiac disease. The long-term prognosis of patients with HPNCG who do not receive an initial diagnosis is good.

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“…The esophageal involvement of these patients consists of active esophagitis, chronic esophagitis (including LE), and reflux esophagitis[8,9,15]. The inflammatory patterns seen in the stomach include chronic active and inactive gastritis (including Helicobacter pylori -associated gastritis), chronic atrophic gastritis, and FEG[10,16,17]. The duodenal inflammation is characterized by crypt inflammation, villous blunting, and increased intraepithelial lymphocytes[18].…”

Section: Clinical Perspectivementioning

confidence: 99%

Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review

Abuquteish

Putra

2019

WJG

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Upper gastrointestinal (UGI) tract involvement of inflammatory bowel disease (IBD) is commonly seen in pediatric patients. Upper endoscopy is included in the routine workup of children with suspected IBD to enhance the diagnosis and management of these patients. Currently, childhood IBD is classified into ulcerative colitis (UC), atypical UC, Crohn’s disease (CD) and IBD unclassified. Histologic confirmation of UGI tract involvement, in particular the presence of epithelioid (non-caseating) granulomas, is helpful in confirming the diagnosis of IBD and its classification. Herein, we reviewed selected IBD-associated UGI tract manifestations in children. Lymphocytic esophagitis, seen predominantly in CD, is histologically characterized by increased intraepithelial lymphocytes (> 20 in one high-power field) in a background of mucosal injury with absence of granulocytes. Focally enhanced gastritis is a form of gastric inflammation in pediatric IBD marked by a focal lymphohistiocytic pit inflammation with or without granulocytes and plasma cells in a relatively normal background gastric mucosa. Duodenal inflammation seen in children with IBD includes cryptitis, villous flattening, increased intraepithelial lymphocytes, and lamina propria eosinophilia. Finally, epithelioid granulomas not associated with ruptured gland/crypt are a diagnostic feature of CD. The clinicopathologic correlation and differential diagnosis of each microscopic finding are discussed. Clinicians and pathologists should be cognizant of the utility and limitations of these histologic features.

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Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Cited by 7 publications

References 34 publications

Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

Prevalence and Clinical Significance of Helicobacter Pylori‐negative Chronic Gastritis in Children

Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review

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