Gastrin and gastric acid secretion in renal failure

Wesdorp, R. I. C.; Falcao, Horacio A.; Banks, Peter B.; Martino, Joseph A.; Fischer, James J.

doi:10.1016/0002-9610(81)90190-2

Cited by 40 publications

(23 citation statements)

References 19 publications

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“…61 As a result, gastric atrophy progresses, accompanied by increased pH, and finally H. pylori are not able to live in gastric mucosa. 62 In this study, there was no significant difference in the prevalence of H. pylori infection between patients with normal renal function and patients receiving less than 1 year of dialysis treatment. Therefore, urea concentration and antibiotic usage are unlikely contributors to decrease the prevalence of infection.…”

Section: Discussionmentioning

confidence: 48%

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Sugimoto

Sakai

Kita

et al. 2009

Kidney International

110

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Patients on hemodialysis often have gastrointestinal complications; however, it is unclear if Helicobacter pylori infection is present in these patients. Here we determined the prevalence of H. pylori infection in 539 Japanese hemodialysis patients by measuring serum anti-H. pylori IgG antibodies. Endoscopy was performed on 299 of these patients and the results were compared to 400 patients with normal renal function who had also undergone endoscopy and sero-testing. A second cohort of 478 dialysis patients, within the original group, was checked serologically for H. pylori infection three times over a four-year observation period. The prevalence of infection in these patients was significantly lower than in those patients with normal renal function, irrespective of the clinical outcomes. The prevalence of H. pylori infection significantly decreased as the duration of dialysis increased, particularly within the first four years following initiation of dialysis. About one-third of patients on dialysis for less than four years became serologically negative for H. pylori infection within this observation period. Our study suggests that although long-term dialysis patients have low prevalence of H. pylori, they still have significant gastroduodenal diseases, such as peptic ulcers, that require endoscopic follow-up.

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Section: Discussionmentioning

confidence: 48%

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Sugimoto

Sakai

Kita

et al. 2009

Kidney International

110

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“…Possible factors that play a role in disturbed gastric motility are increased levels of GI hormones, [30][31][32] such as cholecystokinin and gastrin, which modulate GI motility, retention of uremic toxin, and autonomic nervous system dysfunction. 33,34 Several cytokines that appear in patients with CRF, as well as their retention of uremic toxin, may affect the autonomic and enteric nervous system.…”

Section: Discussionmentioning

confidence: 99%

Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure

et al. 2005

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“…Various factors affect gastric motility in patients with CRF. Among these may be the increased levels of some GI hormones (Taylor et al, 1980;Wesdorp et al, 1981;Sirinek et al, 1984), several kinds of uremic toxin retention (Jones et al, 1969;Nakamura et al, 1990;DeDeyn et al, 1995;Anderstam et al, 1996), and a number of cytokines (Herbelin et al, 1991;Brockhaus et al, 1992;Kimmel et al, 1998;king et al, 1998) that appear in CRF patients. Some kinds of uremic toxin that can induce GI symptoms such as anorexia and bloating is excluded after the hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

Adachi

Kamiya

Hirako

et al. 2007

J. Smooth Muscle Res.

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Background: Gastrointestinal (GI) symptoms are common in patients with chronic renal failure (CRF). We have previously demonstrated that patients with predialysis endstage renal disease showed a high prevalence of GI symptoms and gastric hypomotility, and that gastric hypomotility appears to be an important factor in generating GI symptoms. However, it is not clear whether impaired gastric motor function would improve after hemodialytic treatment. Aims: To examine the relationship between gastric motor function and GI symptoms in CRF patients on hemodialysis. Methods: The study was performed in 19 patients with CRF treated with hemodialysis for more than six months and in 12 matched healthy controls. GI symptom severity was quantified in all patients. Gastric motility was evaluated with cutaneously recorded electrogastrography (EGG) and gastric emptying of semi-solid meals using the 13 C-acetic acid breath test. Results: Six patients had no symptoms, and 11 had slight GI symptoms with a total symptom score of less than 5. Compared with controls, CRF patients revealed no differences in gastric motility parameters, with the exception of a lower percentage of normogastria in EGG at fasting state. Eleven patients had normal gastric motor function (Group A), and eight showed abnormalities of either gastric myoelectrical activity or gastric emptying (Group B). There was no difference in symptom score between Group A and Group B. Conclusions: More than half of the patients with CRF on hemodialysis demonstrated normal gastric motility, and no or slight GI symptoms. Hemodialytic treatment may improve impaired gastric motility and reduce GI symptoms in patients with CRF.

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Gastrin and gastric acid secretion in renal failure

Cited by 40 publications

References 19 publications

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

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