Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure

Hirako, Makoto; Kamiya, Tetsuro; Misu, Naoko; Kobayashi, Yuka; Adachi, Hiroshi; Shikano, Michiko; Matsuhisa, Eriko; Kimura, Genjiro

doi:10.1007/s00535-005-1709-6

Cited by 63 publications

(58 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have previously reported (Hirako et al, 2005) that patients with predialysis end-stage renal disease with severe uremia showed a significanty lower percentage of normogastria in the postprandial states and a lower power ratio in EGGs with delayed gastric emptying compared with healthy controls. In this study, we measured gastric motility in CRF patients undergoing hemodialysis for more than six months to evaluate the effect of maintenance dialysis, and we found no differences in the parameters of gastric motility between these patients and healthy controls.…”

Section: Discussionmentioning

confidence: 97%

“…The methodology has been previously published elsewhere (Hirako et al, 2005). In brief, the EGG was measured using a portable EGG recorder (Digitrapper EGG; Synectics Medical, Stockholm, Sweden).…”

Section: Recording and Analysis Of Eggmentioning

confidence: 99%

“…We have previously demonstrated (Hirako et al, 2005) that the patients with predialysis end-stage renal disease showed a high prevalence of GI symptoms and gastric hypomotility, including impaired gastric myoelectrical activity and delayed gastric emptying, and that gastric hypomotility appears to be an important factor in the generation of GI symptoms. However, it is not clear whether impaired gastric motor function would improve after hemodialytic treatment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

Adachi

Kamiya

Hirako

et al. 2007

J. Smooth Muscle Res.

Self Cite

View full text Add to dashboard Cite

Background: Gastrointestinal (GI) symptoms are common in patients with chronic renal failure (CRF). We have previously demonstrated that patients with predialysis endstage renal disease showed a high prevalence of GI symptoms and gastric hypomotility, and that gastric hypomotility appears to be an important factor in generating GI symptoms. However, it is not clear whether impaired gastric motor function would improve after hemodialytic treatment. Aims: To examine the relationship between gastric motor function and GI symptoms in CRF patients on hemodialysis. Methods: The study was performed in 19 patients with CRF treated with hemodialysis for more than six months and in 12 matched healthy controls. GI symptom severity was quantified in all patients. Gastric motility was evaluated with cutaneously recorded electrogastrography (EGG) and gastric emptying of semi-solid meals using the 13 C-acetic acid breath test. Results: Six patients had no symptoms, and 11 had slight GI symptoms with a total symptom score of less than 5. Compared with controls, CRF patients revealed no differences in gastric motility parameters, with the exception of a lower percentage of normogastria in EGG at fasting state. Eleven patients had normal gastric motor function (Group A), and eight showed abnormalities of either gastric myoelectrical activity or gastric emptying (Group B). There was no difference in symptom score between Group A and Group B. Conclusions: More than half of the patients with CRF on hemodialysis demonstrated normal gastric motility, and no or slight GI symptoms. Hemodialytic treatment may improve impaired gastric motility and reduce GI symptoms in patients with CRF.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Recording and Analysis Of Eggmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

Adachi

Kamiya

Hirako

et al. 2007

J. Smooth Muscle Res.

Self Cite

View full text Add to dashboard Cite

show abstract

“…During the gavage studies, it was noted that the stomachs were enlarged in mice treated with adenine. While it had been previously reported that CKD could alter gastrointestinal motility [33], there was no mention in the animal literature of enlarged stomachs [8,13,14]. The significant enlargement of the stomach caused by adenine supplementation suggested that adenine use in the mouse model might compromise oral administration of test therapies.…”

Section: Discussionmentioning

confidence: 99%

Adenine-induced hyperphosphatemia in a murine model of renal insufficiency

Bobeck¹,

Piccione²,

Bishop³

et al. 2017

Nephrol Renal Dis

View full text Add to dashboard Cite

Hyperphosphatemia in chronic kidney disease (CKD) patients is a risk factor for cardiovascular events, progressive kidney failure, and mortality. Improved therapeutic interventions to control hyperphosphatemia depend greatly on robust animal models that recapitulate the CKD disease process. Murine-based models of CKD as compared to rat models present significant advantages due to available genetic knockout lines that permit mechanistic dissection of CKD etiologies. The rat adenine model of renal failure has been extensively studied, and studies are now emerging describing adenine-induced renal failure in murine models. However, these newly developed murine models have not fully described the responses to calcitriol and phosphate binders, and the reported effects of adenine on serum phosphate is often lacking in murine models. Therefore, the objectives of this study were: 1) To induce hyperphosphatemia in mice using adenine with minimal mortality, and 2) Report the influence of calcitriol and phosphate binders on the disease process through measurement of serum phosphate and histology. In one approach, C57BL/6 male mice gavaged with 4 or 6 mg adenine/day, as compared to 0 mg adenine/day developed hyperphosphatemia, with low mortality. In a second approach, calcitriol exacerbated adenine-induced increases in serum phosphate at day 7 of adenine administration (p<0.05). Notably, adenine treated mice had 4-fold increased stomach weights vs. non-adenine treated mice (p<0.0001). The addition of a phosphate binder (experiment 3, sevelamer hydrochloride) was ineffective at preventing an adenine-induced increase in blood phosphate, a finding that likely resulted from adenine's inhibition of gastric emptying. We report the successful use of adenine to induce hyperphosphatemia, that the hyperphosphatemic status is exacerbated by calcitriol, and a limitation of the model for studying oral therapies for hyperphosphatemia.

show abstract

“…6,8,9 Delayed gastric emptying could influence functional gastrointestinal disorders including gastroesophageal reflux disease, peptic ulcer disease and functional dyspepsia. [10][11][12] Mosapride is a selective 5-hydroxytryptamine type 4 (5-HT 4 ) receptor agonist and has been used in patients with upper gastrointestinal disorders by shortening gastric emptying in healthy volunteers and gastroparesis. 13,14 Gastrin and cholecystokinin (CCK) are homologous gastrointestinal endocrine hormones which are known to regulate gastric acid secretion, gastric emptying, growth of gastric mucosa and intestinal motility in upper gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

Lim

Kim

Youn

et al. 2013

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure

Abstract: The patients with CRF showed gastric hypomotility, including impaired gastric myoelectrical activity and delayed gastric emptying. Gastric hypomotility appears to be an important factor in the generation of GI symptoms in patients with CRF.

Cited by 63 publications

References 40 publications

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

Improvement of gastric motility by hemodialysis in patients with chronic renal failure

Adenine-induced hyperphosphatemia in a murine model of renal insufficiency

Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

Contact Info

Product

Resources

About