Gastric α-tocopherol and β-carotene concentrations in association with Helicobacter pylori infection

Zhang, Zun-Wu; Patchett, Stephen; Perrett, David; Domizio, Paola; Farthing, M. J. G.

doi:10.1097/00042737-200012050-00004

Cited by 45 publications

(41 citation statements)

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“…Therefore, it is considered that there is an effect on atherosclerosis when H. pylori infection induces its higher inflammatory response. Antioxidants have been shown to be decreased in subjects with H. pylori (27). This could contribute to lipid peroxidation, which in turn could result in atherosclerosis (28).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

et al. 2005

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“…A high intake of carotenoids has been shown to prevent the development of H. pylori-associated disease (Zhang et al, 2000;Correa et al, 2000;Nair et al, 2000). As free radicals play an important role in the pathogenesis of gastroduodenal mucosal inflammation, peptic ulcer disease and probably even gastric cancer, various micronutrients are considered to protect the gastric mucosa by scavenging the free radicals.…”

Section: Anti-h Pylori Activitymentioning

confidence: 99%

Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple

Molnár

Kawase

Satoh

et al. 2005

Phytotherapy Research

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Carotenoid fractions were extracted from red paprika, Valencia orange peel and the peel of Golden delicious apple. Thus, hypophasic carotenoids of paprika (PM1), orange (PM3) and apple (PM4), and epiphasic extractions of paprika (PM2) and apple (PM5) were obtained by extraction, saponification and partition between MeOH-H(2)O (9:1) (hypophasic) and hexane (epiphasic). A high content of capsanthin was quantified in hypophasic carotenoids (PM1) from red spice paprika, whereas the hypophasic fractions from orange (PM3) and apple (PM4) were mainly composed of violaxanthin, zeaxanthin and lutein. On the other hand, a high content of beta,beta-carotene and beta-cryptoxanthin was found in epiphasic fractions (PM2 and PM5). The extracts were studied for their anti-Helicobacter pylori (H. pylori), anti-human immunodeficiency virus (HIV), cytotoxic, multidrug resistance (MDR) reversal and radical scavenging activity. Among five PM extracts and beta,betacarotene, PM4 showed potent anti-H. pylori activity (MIC(50) = 36 microg/mL), comparable to metronidazole (MIC(50) = 45 microg/mL). The extracts were inactive against HIV. PM3 and PM4 showed slightly higher cytotoxic activity against three human tumor cell lines (squamous cell carcinoma HSC-2, HSC-3, submandibular gland carcinoma HSG) and human promyelocytic leukemic HL-60 cells than against three normal human oral cells (gingival fibroblast HGF, pulp cell HPC, periodontal ligament fibroblast HPLF), suggesting a tumor-specific cytotoxic activity. PM1, PM3 and PM4 displayed much higher MDR-reversing activity than (+/-)-verapamil. ESR spectroscopy demonstrated that PM1-5 and beta,beta-carotene produced little or no detectable radical under alkaline conditions and did not scavenge the O(2) (-) produced by the hypoxanthine and xanthine oxidase reaction. On the other hand, PM1 and PM2 scavenged efficiently 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, whereas singlet oxygen was also quenched efficiently by PM5 and PM2. The data suggest the potential importance of carotenoids as possible anti-H. pylori and MDR reversal agents. The active principles in the carotenoid extract might differ, depending upon the types of fruits and vegetables.

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“…Gastric inflammation induced by H. pylori colonization releases free radicals, increasing the likelihood of carcinogenesis, and the levels of vitamin C (21)(22)(23), vitamin E (24,25), and β-carotene (25) may be lower when infection is present, suggesting a direct action of these compounds in restraining mucosal damage promoted by H. pylori. Therefore, it may be hypothesized that the increase in gastric cancer risk by H. pylori infection is higher when the levels of antioxidants or the dietary intake of fruit and vegetables are lower, due to a more-limited capacity to protect the stomach from the deleterious effects of H. pylori.…”

mentioning

confidence: 99%

Antioxidant Vitamins and Risk of Gastric Cancer: A Case-Control Study in Portugal

Lunet

Valbuena²,

Carneiro³

et al. 2006

Nutrition and Cancer

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We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and 1.33 (95% CI = 0.77-2.30) for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer.

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Gastric α-tocopherol and β-carotene concentrations in association with Helicobacter pylori infection

Cited by 45 publications

References 0 publications

Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple

Antioxidant Vitamins and Risk of Gastric Cancer: A Case-Control Study in Portugal

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