Gastric ulcer localization: Potential use of 125I-omeprazole as radiotracer

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

“…Interestingly, the practically obtained RY was found to be 93.99% using the optimized conditions executed from PSO. The obtained product was confirmed to be stable in vitro up to 8 h. Although the RY of 125 I‐OMP, which previously reported by Amin et al, was 97% using the traditional tedious and time‐consuming radiolabeling method, all of the authors recommend the use of FFDA coupled with PSO in radiolabeling optimization processes as a simple, easy, costless, effortless, and effective method, which reduces overall personal exposure to radiation risk. This novel hybrid technique was considered as a developed step in RP manufacturing.…”

Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection

“…(Figure A) more than in the case of normal stomach and was confirmed by gamma camera analysis (see Figure ). The published %ID/g ± SD for a number of common of proton pump inhibitors, eg, [ 99m Tc]pantoprazole, [ 99m Tc]omeprazole, [ 99m Tc]rabeprazole, [ 125 I]iodofamotidine, [ 125 I]iodoomeprazole, and [ 131 I]iodorabeprazole, shows a maximum uptake in stomach ulcer of 27.2% ID/g at 30 minutes, 22.0% ID/g at 1 hour, 33.4% ID/g at 30 minutes, 65.9% ID/g at 30 minutes, 47.3% ID/g at 4 hours, and 38.00% at 1 hour, respectively. Our results indicate that iodonizatidine has a higher %ID/g ± SD value than these materials have.…”

“…Iodine 123 is the isotope of choice for medical imaging with a half‐life to 13.22 hours and decays by emission of gamma radiation with an energy of 159 keV. However, its short half‐life and expense necessitate that iodine 125 be used to develop the labeling procedure and evaluate the biodistribution in mice . Two different groups of mice, one bearing stomach ulcers and the other not, were injected with [ 125 I]iodonizatidine and the results were compared.…”

“…However, its short half-life and expense necessitate that iodine 125 be used to develop the labeling procedure and evaluate the biodistribution in mice. [11][12][13] Two different groups of mice, one bearing stomach ulcers and the other not, were injected with [ 125 I]iodonizatidine and the results were compared. The structures for nizatidine and [ 125 I]iodonizatidine are shown in Figure 1 and an unlabelled iodination used for proof of structure.…”