Gastric signet‐ring cell lymphoma with alpha heavy chains

Abstract

Signet-ring cell lymphomas are rare especially as primary gastric tumours; alpha chain disease of the stomach is also unusual. A case of gastric signet-ring cell lymphoma with free alpha chains in the gastro-duodenal juice is reported and its light microscopic, immunohistological and ultrastructural features are described. Although the morphogenesis of signet-ring cell lymphoma is not clear, the present case showed many of the features of a mucosa-associated lymphoma. This rare variant of follicle centre cell lymphoma may easily be mistaken for a signet-ring cell carcinoma. A search for abnormal immunoglobulins should be made in serum, secretions or tissues in future cases of signet-ring cell lymphoma.

A Rare Presentation of Gastric Signet Ring Cells: Signet Ring Cell Lymphoma

“…Sumida et al, have reported a case of H. pylori and API2-MALT1 gene-negative gastric mucosa-associated lymphoid tissue lymphoma with a carcinoma-like signet-ring cell lymphoepithelial lesion [6]. An interesting case of gastric signet-ring cell lymphoma with free alpha chains in the gastro-duodenal juice was also reported earlier [7]. Zamboni et al, noted carcinoma like signet ring cells in 26 out of 70 gastric mucosa-associated lymphoid tissue (MALT) Lymphomas.…”

Cytologic Features of Primary Signet Ring Cell Carcinoma of the Bladder

“…10,11 Signet ring cells are rarely observed in urine cytology. In a urinary smear, they can be seen in urachal adenocarcinoma of the bladder, urothelial carcinoma with signet ring cell component, 8 nephrogenic adenoma, 12 renal adenocarcinoma, 13 signet ring cell carcinoma of the bladder, 8 lymphoma, 14,15 carcinoid tumor 16 and metastatic adenocarcinoma of the bladder. 17 These diseases must be excluded before a final diagnosis of signet ring cell adenocarcinoma of the bladder is made.…”

Malignant Hematopoietic Breast Tumors

“…and KP-1 (CD68; 1:800) (all from Dako, Carpenteria, Calif); CD2 (1:50), CD3 (1:700), CD4 (1:100), CD5 (1:100), CD8 (1:100), CD34 (1:100), and Leu-Ml (CD15; 1:150) (all from Becton Dickinson, San Jose, Calif); MB2 (1:80) and MT1 (1:80) (both from Biotest Diagnostics, Denville, NJ); Ki-1 (CD30; 1:300) (from AMAC, Westbrook, Me); gross cystic disease fluid protein-15 (GCDFP-15; 1:20) (from Signet, Dedham, Mass). In addition, immunostains for B-and T-cell markers were performed in 12 cases (cases 11,12,14,19,21,26,27,30,32,37,43, and 45) not originally immunophenotyped and for which paraffin tissue blocks were available. The results of flow cytometric analysis performed on 4 cases (cases 11, 20, 29, and 40) were also reviewed.…”