Malignant Hematopoietic Breast Tumors

Lin, Yuan; Govindan, Ramaswamy; Hess, Jay L.

doi:10.1093/ajcp/107.2.177

Cited by 48 publications

(23 citation statements)

References 11 publications

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“…Most publications on this topic are case reports or small series of single institutions. Lin et al [14] analysed a series of 21 primary and 19 secondary NHLs in the breast, finding a median age of 67 and 61 years and a predominance of intermediate or poor differentiation and of the diffuse largecell type. Primary and secondary lymphomas of the breast are indistinguishable on morphologic grounds [1] and seem to occur equally frequent [21].…”

Section: Introductionmentioning

confidence: 99%

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

et al. 2006

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Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.

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Section: Introductionmentioning

confidence: 99%

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

et al. 2006

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“…T-cell lymphomas of the breast have been reported rarely, and few of these occur without an associated implant. 3,4 In recent years, there have been several case reports of patients developing lymphomas in close proximity to silicone or saline breast implants. [5][6][7][8][9][10][11][12][13] Interestingly, the majority of implant-associated lymphomas were T-cell lymphomas, including anaplastic large-cell lymphoma (n ¼ 5) [5][6][7]13 and mycosis fungoides/Sézary syndrome (n ¼ 4).…”

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confidence: 99%

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

et al. 2008

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Non-Hodgkin lymphomas of the breast are rare, encompassing approximately 0.04-0.5% of all malignant breast tumors, and the vast majority are B-cell lymphomas. In contrast, lymphomas of T-cell phenotype have been rarely reported and some of these have been in close proximity to a breast implant. In our consultation practice, we have identified four patients with primary T-cell anaplastic large-cell lymphoma presenting adjacent to silicone or saline breast implants. All patients presented with seroma and neoplastic cells were identified in suspension in the serous fluid without solid tissue invasion. Three patients had no evidence of systemic disease (stage 1E), and one patient was not staged. The mean age of the patients was 46 years (range, 34-59 years). In all patients, the neoplastic cells had a T-cell phenotype, expressed CD30, cytotoxic granuleassociated proteins, EMA and clusterin, and were anaplastic lymphoma kinase-1-negative. Clonal T-cell receptor c-chain gene rearrangements were identified in three patients. All patients underwent capsulectomy with removal of the implant. One patient subsequently received chemotherapy and radiation therapy, and another was treated with radiation alone. The third patient received no further therapy and the fourth patient has been recently diagnosed. After a mean time of 13 months (range, 9-20 months), all three patients with follow-up were alive and well without any recurrence or systemic disease. Although the follow-up time was relatively short, our series and other reported cases suggest that primary anaplastic large-cell lymphoma adjacent to breast implants is an indolent T-cell lymphoproliferative disorder. Keywords: anaplastic large-cell lymphoma; primary lymphoma of breast; breast implant; silicone; saline Non-Hodgkin lymphomas of the breast are rare and comprise approximately 0.04-0.5% of all malignant breast tumors and 2.2% of extranodal lymphomas.

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“…Anaplastic large cell lymphoma, as in Case 1, has been reported previously in two series (13,14) and one case report (47). Whether, in our case, the skin involvement was primary or secondary to the underlying malignancy could not be determined with our specimen.…”

Section: Discussionmentioning

confidence: 55%

“…Single case reports of T-cell lymphoma of the breast also are found in the literature (39 -47). Reports have included lymphoblastic lymphoma (1,3,9); anaplastic large cell (ALCL) (CD30 positive) (13,14,47); peripheral T-cell (PTCL; including large cell, pleomorphic, and high grade) (8, 14 -17, 39, 40, 45, 46); adult T-cell, human T-cell lymphoma-related (41); multilobated (42); and mycosis fungoides (43,44).…”

mentioning

confidence: 99%

T-Cell Lymphoma Presenting in the Breast: A Histologic, Immunophenotypic and Molecular Genetic Study of Four Cases

et al. 2000

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Malignant Hematopoietic Breast Tumors

Cited by 48 publications

References 11 publications

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

T-Cell Lymphoma Presenting in the Breast: A Histologic, Immunophenotypic and Molecular Genetic Study of Four Cases

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