Gastric Secretion in Heidenhain Pouches Following Section of Vagus Nerves to Main Stomach

Abstract

If through the decomposition Of ATP by its 'enzyme ATPase, (tonus and constrictison of the artery are maintained, it is possible that a drug which acutely relaxes the artery may do SO by interfering with the ATPase activity of the tissue. Studies aimed at clarifying this postulate are in progress. v102, 16.John C., Jr., Anal. Chem., in press.

Effect of Truncal Vagotomy on the Increase in Gastric Acid Secretion Induced by Small Bowel Resection in Dogs

“…This finding differs from the effect of truncal vagotomy on the acid response to pentagastrin in the human [2.9, 10,12], It is difficult to compare the present results with those of experiments in which the truncal vagotomy had been performed in dogs with vagally denervated gastric pouches, since with this latter preparation vagotomy increases the acid response to a meal [3,4,16,17]. Studies using Heidenhain pouches have therefore measured the changes in acid secretion resulting from denervation of the remaining stomach, intestine, and other abdominal viscera, rather than the direct effect of vagal denervation of the parietal cells within the pouch.…”

Vagotomy-Pyloroplasty

“…Others have reported similar results. 4 Since the Heidenhain pouch reflects mostly the antral or gastric phase of gastric secretion, most of the hypersection following vagotomy is felt to be due to antral stimulation. The intestinal phase has also been found to be augmented; however, this is to a much lesser degree.…”

Pyloric Effects on Gastric Secretion And Emptying

“…4,9 The chief cause of this phenomenon is felt to be due to excessive antral stimulation which results in an increased liberation of gastrin. Excessive (Table 3).…”