Effect of Truncal Vagotomy on the Increase in Gastric Acid Secretion Induced by Small Bowel Resection in Dogs

Abstract

In dogs with vagally innervated gastric pouches, a study has been made of the effect of a truncal vagotomy on gastric hypersecretion induced by extensive small bowel resection. Truncal vagotomy after small bowel resection produced a marked reduction in the early part of the acid all response to a meal, but was without effect on the later increased part of the response to the meal, or on the total 24-hour secretion induced by the intestinal resection.

Effect of Jejunal Resection on the Gastric Acid Secretory Response to Pentagastrin, Histamine and Feeding in Dogs

“…These data indicate that both an increase in stimulation and an increase of the response to this stimulation are responsible for the increased acid secretion observed in the pouch when resected dogs were fed. These effects could be explained by the withdrawal of inhibitors of intestinal origin.Gastric acid hypersecretion following small bowel resection or exclusion is well recognized in dogs, but the underlying mechanism remains undefined (5,7,11,14,16,18,20,21,26,33,35). The increase in acid secretion could result either from a change in stimulation or inhibition of gastric secretion, or from a change at the parietal cell level.…”