Gastric schwannoma: a diagnosis that should be known in 2019

Lomdo, Massama; Setti, Khadija; Oukabli, Mohamed; Moujahid, Mountassir; Bourazza, Ahmed

doi:10.1093/jscr/rjz382

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…In CT examination, GS usually shows a clear oval tumor under the gastric mucosa, with an exogenous or mixed growth mode, moderate uniform, or moderate progressive enhancement. Most surrounding lymph nodes do not appear to be enlarged [ 13 ], there might be a few of the enlarged perigastric lymph nodes seen that are reactive inflammatory lymph nodes [ 14 ]. Hong et al reported their findings after examining 16 cases of GS at their institution on CT scans, of which 13 cases (81%) showed uniform enhancement [ 15 ], and they were all prominent growths, consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of gastric schwannoma and review of related literature

Zhong

Liu

et al. 2022

BMC Surg

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Background This study aimed to investigate the clinical features, diagnostic criteria, treatment options, and prognosis of patients with gastric schwannoma (GS). Methods We collected the clinical data of all patients pathologically diagnosed with GS in Zhejiang Provincial People's Hospital from May 2012 to October 2021. Results A total of 26 cases of GS were analyzed clinicopathologically, where the sizes of the tumor were found to be in the range of 1–6 cm (mean: 3.16 cm, median: 3.05 cm). A computed tomography (CT) scan analysis revealed that most masses were either moderately progressive or uniformly enhanced. According to ultrasound gastroscopy results, most of them were hypoechoic masses. There were 23 cases of surgery and three cases of endoscopic submucosal tumor dissection. Immunohistochemistry demonstrated that S100 was positive in 26 patients, immunomarker SOX10 was positive in five, whereas CD34, CD117, and SMA were negative in most patients. CK (Pan), Dog-1, and Desmin were also found negative. All 26 cases were followed up after the conclusion of the study where no evidence of recurrence or metastasis was observed. Conclusions GS is a unique form of peripheral schwannoma. The diagnosis of this type of tumor depends on the pathology and immunohistochemistry of the individual. The key to treating this type of tumor is endoscopy and surgery. Follow up and related literature review showed that GS was a benign tumor with little possibility of malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological study of gastric schwannoma and review of related literature

Zhong

Liu

et al. 2022

BMC Surg

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“…GS shows positive staining for S100, vimentin, Leu-7, glial fibrillary acidic protein (GFAP), myelin-associated glycoprotein, and nonspecific enolase while desmin, CD117, striated muscle actin, smooth muscle actin, and myosin stain negative on immunohistochemistry [ 1 , 6 , 8 ]. Peritumoral lymphoid cutoff is another feature that helps to differentiate GS from GIST [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite these options, complete surgical excision of the tumor is considered as the gold standard for the management of GS. Endoscopic resection is another treatment option that have been described recently but is limited by the tumors > 3 cm and location within the muscularis propria as it usually requires surgical excision because of increased risk of perforation [ 6 , 8 , 9 , 10 ]. This was the case in our patient who underwent complete surgical resection due to tumor size of 4.2 cm and location in the muscularis propria.…”

Section: Discussionmentioning

confidence: 99%

Gastric Schwannoma: A Case Report and Literature Review

Khan¹,

Honganur²,

Kumar³

et al. 2022

Cureus

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Gastric schwannomas (GS) are very rare spindle cell, submucosal mesenchymal tumors that arise from Schwann cells of nerve plexuses in the stomach wall. They are usually benign but can become malignant and metastasize to other organs. Surgical resection with biopsy is the gold standard for diagnosis and management of GS. In this article, we present a 68-year-old female patient who presented with abdominal pain, nausea, vomiting, and belching for a couple of months. Upon further evaluation, she was found to have a 4.2 cm gastric mass, which was consistent with gastric schwannoma through biopsy and immunohistochemistry. The patient underwent complete surgical resection of the tumor without any complications. In this article, we will discuss the literature about GS including its clinical presentation, diagnosis, and management options.

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“…Depending on the seriesthere is a slight female predominance [4][5][6].The GS is usually in the form of an isolated lesion and is usually localized in the body of the stomach [7,8].…”

Section: Case Reportmentioning

confidence: 99%

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2022

Clin Med Rev Case Rep

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Schwannoma is a benign tumor, that mainly occurs in the nerve endings of the head and neck, and more rarely in the gastrointestinal tract. In the latter case, it appears as a submucosal tumor (SMT), which elective site is the stomach. Gastric schwannoma (GS) accounts for 0.2% of all gastric tumors and is mostly benign slow-growing, and very often asymptomatic. Its diagnosis can only be confirmed by a histopathological examination, which allows the distinction between a GS and other SMTs, particularly gastrointestinal stromal tumors (or GIST). Once a submucosal gastric mass's cells are positive for S-100 protein, the diagnosis of a gastric schwannoma is made. The best treatment remains complete resection with wide margins in the latter case.We describe here the case of a 67-year-old woman, treated for a gastric schwannoma, revealed by abdominal discomfort for the previous 6 months. After full assessment including abdominal computed tomography (CT), upper digestive endoscopy, and gastric biopsy, we discovered a submucosal gastric lesion with benign macroscopic features, with no evidence of lymph nodes or metastatic involvement. She underwent atypical mid-gastric resection with gastro-gastric anastomosis. The final histopathological study with complementary immunohistochemical staining revealed a spindle cell tumor proliferation mimicking a gastrointestinal stromal tumor (GIST), with cells that were mainly positive for S-100 protein, and negative for CD 117 (or C-Kit). Given the good prognosis of the tumor, no adjuvant treatment was proposed apart from simple biannual clinical monitoring. With a follow-up of 28 months, the control is still satisfactory.

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Gastric schwannoma: a diagnosis that should be known in 2019

Cited by 7 publications

References 8 publications

Clinicopathological study of gastric schwannoma and review of related literature

Clinicopathological study of gastric schwannoma and review of related literature

Gastric Schwannoma: A Case Report and Literature Review

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