Gastric pythiosis in a dog

Fernandes, Ciciane Pereira Marten; Giordani, Cláudia; Grecco, Fabiane Borelli; Sallis, Eliza Simone Viégas; Stainki, Daniel Roulim; Gaspar, Luiz Fernando Jantzen; Ribeiro, Carmen Lucia Garcez; Nobre, M. O.

doi:10.1016/j.riam.2012.01.002

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…A infecção é mais frequente em cães e animais de produção, sendo os equinos os mais acometidos e em humanos e felinos a doença é rara (MENDOZA; HERNANDEZ; AJELLO, 1993;PRASERTWITAYAKIJ et al, 2003;RAKI-CH;GROOTERS;TANG, 2005;MARQUES, 2011;FERNANDES et al, 2012). Em estudos realizados em equinos infectados não se observou predisposição para raça, sexo ou idade dos animais (MENDOZA;ALFARO, 1986).…”

Section: Aspectos Epidemiológicosunclassified

Pitiose Equina: Revisão De Literatura

Becegatto

Zanuttom

Cardoso

et al. 2017

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a pitiose é uma enfermidade que afeta diversas espécies animais, sendo a espécie equina geralmente a mais acometida. É causada por um oomiceto que se desenvolve principalmente em regiões subtropicais e tropicais em áreas alagadiças. As lesões frequentemente são únicas, bastante exsudativas, com prurido moderado a intenso e tendem a se localizar nas regiões do corpo que mais entram em contato com as áreas alagadas. Os meios de diagnostico e tratamento vêm sendo estudados surgindo assim cada vez mais técnicas e alternativas. Por ser uma doença que pode causar diversos impactos econômicos, seja por gastos com o tratamento ou até perda da função ou morte do animal, é uma doença que merece atenção no mercado de equinos no Brasil e no mundo. Este trabalho tem por objetivo abordar as principais características da pitiose, seu diagnóstico, tratamento e possíveis impactos.

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Section: Aspectos Epidemiológicosunclassified

Pitiose Equina: Revisão De Literatura

Becegatto

Zanuttom

Cardoso

et al. 2017

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“…P. insidiosum inhabits freshwater and presents in two forms: mycelium and zoospore [30,31,32]. Clinical manifestations of pythiosis include an infection of artery, eye, skin, or gastrointestinal tract [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50]. Pythiosis exhibits high morbidity and mortality rates [7,8,28,49,51].…”

Section: Introductionmentioning

confidence: 99%

Review of methods and antimicrobial agents for susceptibility testing against Pythium insidiosum

Yolanda

Krajaejun

2020

Heliyon

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Pythiosis is a life-threatening infectious disease of humans and animals caused by the oomycete microorganism Pythium insidiosum. The disease has been increasingly diagnosed worldwide. P. insidiosum inhabits freshwater and presents in two forms: mycelium and zoospore. Clinical manifestations of pythiosis include an infection of the artery, eye, skin, or gastrointestinal tract. The management of pythiosis is problematic due to the lack of effective treatment. Many patients die from an uncontrolled infection. The drug susceptibility testing provides clinicallyuseful information that could lead to proper drug selection against P. insidiosum. Currently, no standard CLSI protocol for the drug susceptibility of P. insidiosum is available. This review aims at describing methods and antimicrobial agents for susceptibility testing against P. insidiosum. Several in-house in vitro susceptibility methods (i.e., broth microdilution method, radial growth method, and agar diffusion method) have been established for P. insidiosum. Either mycelium or zoospore can be an inoculum. Rabbit is the commonly-used model of pythiosis for in vivo drug susceptibility testing. Based on the susceptibility results (i.e., minimal inhibitory concentration and inhibition zone), several antibacterial and antifungal drugs, alone or combination, exhibited an in vitro or in vivo effect against P. insidiosum. Some distinct compounds, antiseptic agents, essential oils, and plant extracts, also show anti-P. insidiosum activities. Successfully medical treatment, guided by the drug susceptibility data, has been reported in some pythiosis patients. Future studies should emphasize finding a novel and effective anti-P. insidiosum drug, standardizing in vitro susceptibility method and correlating drug susceptibility data and clinical outcome of pythiosis patients for a better interpretation of the susceptibility results.

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“…A doença ocorre esporadicamente em cães no semiárido nordestino, entretanto deve ser incluída no diagnostico diferencial das doenças em cães com evolução crônica e proliferativa que acometem o sistema gastrintestinal, e frente a lesões cutâneas de difícil tratamento. (Fernandes et al 2012), affects several species of domestic animals, wildlife and humans (Camus et al 2004, Rakich et al 2005, Santurio et al 2006, Martins et al 2012. The equine species is the most affected, followed by the dogs (Leal et al 2001, Santurio et al 2006, Torres Neto et al 2009).…”

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“…The gastrointestinal tract lesions are characterized by thickening of the wall of the stomach and intestine (Trost et al 2009, Fernandes et al 2012, and may occur great masses with involvement by extension to the pancreas, mesentery, lymph nodes, liver, uterus and prostate (Miller 1985, Jaeger et al 2002, Grooters & Foil 2012. There are also reports of mass in the esophagus, the oropharyngeal region and larynx (Patton et al 1996, Helman & Oliver 1999.…”

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Pythiosis in dogs in the semiarid region of Northeast Brazil

et al. 2017

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RESUMO.-[Pitiose em cães na região semiárida do Nordeste, Brasil.] Descrevem-se os aspectos epidemiológicos, clínicos e patológicos de cinco casos de pitiose em cães na região semiárida do Nordeste. A doença ocorreu em cães com idade entre um e três anos, fêmeas e machos, de diferentes raças. Os cães eram criados em zona urbana, mas ocasionalmente eram levados para zona rural e tinham contato com áreas alagadas. Em um caso não havia informações no histórico sobre acesso à zona rural. Os principais sinais clínicos observados foram perda de peso, vômito, diarreia e tenesmo.Macroscopicamente havia espessamento da parede do intestino com massas firmes, irregulares, com áreas granulares amareladas entremeadas por tecido esbranquiçado, no duodeno, cólon e reto, que se estendia ao pâncreas e linfonodos, além de fígado e vagina. Na pele havia área de alopecia e ulcerações irregulares, algumas contendo pequenas cavitações com secreção serosanguinolenta. Microscopicamente havia inflamação piogranulomatosa e em um caso também havia necrose eosinofílica associada a imagens negativas tubuliformes pela hematoxilina e eosina, fortemente impregnadas pelo GMS e fracamente coradas pelo PAS. As hifas foram fortemente imunomarcadas pela imuno-histoquímica com anticorpo policlonal anti-Pythium insidiosum. A doença ocorre esporadicamente em cães no semiárido nordestino, entretanto deve ser incluída no diagnostico diferencial das doenças em cães com evolução crônica e proliferativa que acometem o sistema gastrintestinal, e frente a lesões cutâneas de difícil tratamento. We describe the epidemiological, clinical and pathological features of five cases of pythiosis in dogs in northeast semiarid. The disease occurred in dogs with age between one and three years, females and males of different breeds. The dogs were created in urban areas, but were occasionally taken to the countryside and then had contact with wetlands. The main clinical signs were weight loss, vomiting, diarrhea and tenesmus. Macroscopically there were intestinal wall thickening with irregular firm masses with yellowish granular areas interspersed with a whitish tissue, involving the duodenum, colon and rectum, extending to the lymph nodes and pancreas, and the vagina and liver. In the skin there were areas of alopecia and irregular ulcerations, some containing small cavitations with serosanguineous secretion. Microscopically there were pyogranulomatous inflammation and in one case also there were eosinophilic necrosis associated with negative images tubuliformes by hematoxylin and eosin, strongly stained by GMS and weakly by PAS. Hyphae were strongly marked by immunohistochemistry with polyclonal anti-Pythium insidiosum. The disease occurs sporadically in dogs in the semiarid Northeast, however should be included in the differential diagnosis of chronic diseases and proliferative aspect of the gastrointestinal system, and front skin lesions of difficult treatment.

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Gastric pythiosis in a dog

Cited by 9 publications

References 15 publications

Pitiose Equina: Revisão De Literatura

Pitiose Equina: Revisão De Literatura

Review of methods and antimicrobial agents for susceptibility testing against Pythium insidiosum

Pythiosis in dogs in the semiarid region of Northeast Brazil

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