Gastric Lymphoma vs Adenocarcinoma

Macon, William L.

doi:10.1001/archsurg.1979.01370270075013

Cited by 5 publications

(2 citation statements)

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“…In contrast the four other reported cases of gastric signet-ring cell lymphoma had Russell body type eosinophilic cytoplasmic inclusions which make them less likely, on H & E examination, to be confused with a signet-ring cell carcinoma (Navas-Palacios et al 1983, Hernandez & Sheehan 1985. The differentiation from the latter is vital since the therapeutic and prognostic implications of the two diagnoses differ widely (Macon 1979, Vernon et al 1979). The so-called 'lympho-epithelial lesion' produced by infiltration and eventual destruction of the glands by malignant follicle centre cells proved a valuable diagnostic feature (Moore & Wright 1984).…”

Section: Discussionmentioning

confidence: 99%

Gastric signet‐ring cell lymphoma with alpha heavy chains

Tungekar

1986

Histopathology

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Signet-ring cell lymphomas are rare especially as primary gastric tumours; alpha chain disease of the stomach is also unusual. A case of gastric signet-ring cell lymphoma with free alpha chains in the gastro-duodenal juice is reported and its light microscopic, immunohistological and ultrastructural features are described. Although the morphogenesis of signet-ring cell lymphoma is not clear, the present case showed many of the features of a mucosa-associated lymphoma. This rare variant of follicle centre cell lymphoma may easily be mistaken for a signet-ring cell carcinoma. A search for abnormal immunoglobulins should be made in serum, secretions or tissues in future cases of signet-ring cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Gastric signet‐ring cell lymphoma with alpha heavy chains

Tungekar

1986

Histopathology

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“…Primary gastric lymphomas represent a small proportion of all stomach malignancies (1-7 %) (Radaszkiewicz & Dragosics 1980) but are an important group of tumours since they behave differently and have a much better prognosis than adenocarcinomas of the stomach. The five year survival rate for lymphoma of the stomach is 20-50 % compared with 10-30 % for adenocarcinoma (Contreary, Nance and Becker, 1980;Macon, 1979). They also have a better prognosis than nodal lymphomas.…”

Section: Introductionmentioning

confidence: 99%

Primary gastric lymphoma—a tumour of mucosa‐associated lymphoid tissue. A histological and immunohistochemical study of 36 cases

Moore

Wright

1984

Histopathology

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Primary gastric lymphoma-a tumour of mucosa-associated lymphoid tissue. A histological and immunohistochemical study of 36 casesA series of 36 cases of non-Hodgkin's lymphoma of the stomach have been analysed using routine histological techniques and immunohistochemistry. All cases were categorized as follicle centre cell lymphomas. Apart from two cases who had nodal lymphomas followed by gastric lymphomas, all cases appeared to represent primary lymphoma of mucosa-associated lymphoid tissue. It is proposed that the morphology and behaviour of these tumours reflect their origin from gutassociated lymphoid tissue. Physiologically well-differentiated examples show monotypic plasmacytic differentiation. Infiltration of gastric glands by follicle centre cells forming characteristic lympho-epithelial lesions is, we believe, a pathognomonic feature of primary gastric lymphoma. The spread of these tumours is within the mucosa-associated lymphoid tissues involving, in particular, the nasopharynx and lung but seldom spreading to peripheral lymph nodes or bone marrow. This concept of gastric lymphomas as primary neoplasms of gut-associated lymphoid tissue has important implications with respect to the investigation and treatment of this disease.

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