Gastric Emptying of Starch Meals in the Newborn

Husband, Janet; Husband, Peter; Mallinson, C. N.

doi:10.1016/s0140-6736(70)91332-2

Cited by 40 publications

(15 citation statements)

References 11 publications

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“…This also suggests that the site of the receptor is located past the site of hydrolysis, as was suggested by Hunt (1960) and by Elias, Gibson, Greenwood, Hunt & Tripp (1968). Husband, Husband & Mallinson (1970) studied the rate of gastric emptying in infants of starch and glucose solutions.…”

Section: Discussionmentioning

confidence: 74%

The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man.

Vist

Maughan

1995

The Journal of Physiology

191

135

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1. The effect of osmolality and carbohydrate content on the rate of gastric emptying was assessed by using the double sampling gastric aspiration technique to measure the rate of gastric emptying of isoenergetic and isosmotic solutions of glucose and glucose polymer. Six healthy male subjects were each studied on four separate occasions using a test drink volume of 600 ml.2. The half-emptying time (t1, mean + S.E.M.) for a dilute (40 g 1-1) solution of glucose (LG, 230 mosmol kg-') was 17 + 1 min. This was greater than that (14 + 1 min) for a glucose polymer solution with the same energy content (LP, 42 mosmol kg-). A concentrated (188 g l-) glucose polymer solution (HP, 237 mosmol kg-') emptied faster (t1 = 64 + 8 min)than the corresponding isoenergetic glucose solution (HG, 1300 mosmol kg-, t½= 130+ 18min). 3. The dilute (40 g F-) glucose solution emptied faster than the concentrated (188 g F-) glucose polymer solution with the same osmolality (LG, 230 mosmol kg-'; HP, 237 mosmol kg-'). 4. The two dilute solutions (40 g F') delivered a similar amount of carbohydrate to the small intestine, whereas the concentrated (188 g F-) glucose polymer solution delivered a greater amount of carbohydrate at 20, 40 and 50 min than the isoenergetic glucose solution. 5. These results indicate that both osmolality and carbohydrate content influence gastric emptying of liquids in man, but the carbohydrate content appears to have greater influence than osmolality. The osmolality effect is more marked at high concentrations of carbohydrate.The rate of gastric emptying in man has been shown to be slowed both by an increase in carbohydrate content and by an increase in osmolality (Hunt & Knox, 1968;Costill & Saltin, 1974;Barker, Cochrane, Corbett, Dufton, Hunt & Roberts, 1978;Foster, Costill & Fink, 1980)

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Section: Discussionmentioning

confidence: 74%

The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man.

Vist

Maughan

1995

The Journal of Physiology

191

135

View full text Add to dashboard Cite

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“…The only previous report on this subject [9] showed that phototherapy had no effect on gastric emptying, but most of the patients investigated had mild jaundice by our stan dards (mean serum bilirubin concentration 227 pmol/1 SE ± 20.9), a constant-volume test feed was used for infants weighing 1,490-3,380 g and the test feed was 10% dextrose, a solution known to inhibit gastric emptying in the newborn [6,17,18]. Our findings confirm that phototherapy per se has no effect on gas tric emptying, but, whereas gastric emptying before phototherapy did not differ from nor mal in the patients of Blumenthal et al [9], in our more severly jaundiced infants gastric emptying was impaired, and returned to nor mal if phototherapy successfully reduced the serum bilirubin concentration.…”

Section: Discussionmentioning

confidence: 83%

Effects of Jaundice and Phototherapy on Gastric Emptying in the Newborn

et al. 1984

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Gastric emptying rate was measured in term infants without jaundice, with mild jaundice, and with moderate jaundice before and after phototherapy. Gastric emptying was significantly delayed in the moderately jaundiced infants (serum unconjugated bilirubin 233–332 μmol/l) but returned to normal following phototherapy. Mild jaundice (serum unconjugated bilirubin 170–204 μmol/l) had no effect on gastric empyting. Jaundice appears to inhibit gastric emptying, and phototherapy influences emptying indirectly by lowering serum bilirubin concentration. This effect is likely to be of clinical significance in a small minority of jaundiced infants.

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“…It is therefore suggested that oral Caloreen glucose polymer might reasonably replace the intravenous glucose component in Beard's (8) combined oral and intravenous regimen. As a glucose polymer Caloreen has much less osmotic activity than the glucose solutions recommended by Thieme & Tiller (16) and Pardou (17) for the prevention of neonatal hypoglycaemia, and unlike starch (18,19) it appears to be well absorbed in the neonatal period (3, 4, 5), presumably because intestinal glucosidase activity is well developed early in fetal life (20) whereas pancreatic amylase activity is not. Its gradual but sustained absorption would be similar to that of a glucose infusion which is known to reduce the problems of hyperinsulinaemia in IDMs (21).…”

Section: Discussionmentioning

confidence: 99%

Effects on Plasma Glucose Concentration of Light‐for‐date Infants and Infants of Diabetic Mothers of Feeds Supplemented with a Glucose Polymer

et al. 1985

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Serial plasma glucose estimations were performed in 44 light-for-date infants and 17 infants of diabetic mothers fed 2, 3 or 4-hourly with feeds containing 10% additional carbohydrate in the form of a glucose polymer (Caloreen). In the infants fed 2 and 3-hourly, plasma glucose was higher following the high carbohydrate feeds, particularly immediately before the next feed was due. Given 4-hourly, the high carbohydrate feed had little effect in most light-for-date infants, and in one light-for-date infant and two infants of diabetic mothers the plasma glucose was lower at the end of 4 hours than following normal formula. It is concluded that the addition of glucose polymer to feeds given 2 and 3 hourly has a potentially useful effect in neonates at risk of developing hypoglycaemia, but it cannot be used to increase the feed interval to 4 hours.

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Gastric Emptying of Starch Meals in the Newborn

Cited by 40 publications

References 11 publications

The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man.

The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man.

Effects of Jaundice and Phototherapy on Gastric Emptying in the Newborn

Effects on Plasma Glucose Concentration of Light‐for‐date Infants and Infants of Diabetic Mothers of Feeds Supplemented with a Glucose Polymer

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