Gastric carcinoma metastatic to the site of a congenital melanocytic nevus

Betke, Matthias; Süss, Rosita; Hohenleutner, Ulrích; Lübke, Silvia; Eckert, F.

doi:10.1016/0190-9622(93)70120-i

Cited by 24 publications

(20 citation statements)

References 9 publications

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“…Cutaneous métastases from gastric carcinoma usually occur as single or multiple firm, non-ulcerated nodules, and they occur mostly on the abdominal wall, fypically in the periumbilical area, where they are known as Sister Mary Joseph nodules (3,4). However, various cutaneous manifestations, such as figúrate erythema (5), alopecia neoplástica (6), and erythema annulare centrifugum (7), have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Incidental Gastric Signet-ring Cell Carcinoma Metastasis to the Skin in Basal Cell Carcinoma

Nakamura¹,

Satomi²,

Noguchi³

et al. 2012

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 99%

Incidental Gastric Signet-ring Cell Carcinoma Metastasis to the Skin in Basal Cell Carcinoma

Nakamura¹,

Satomi²,

Noguchi³

et al. 2012

Acta Derm Venerol

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“…Several reports have described the differential diagnosis of cutaneous metastasis from gastric cancer and primary sweat gland carcinoma. 5,6,9,11 However, distinguishing gastric cancer metastasis from primary sweat gland carcinoma remains problematic. In human gastric mucosa, gastric gland mucin is produced by mucous neck cells, cardiac gland cells, and pyloric gland cells, and plays an important role in protecting the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…4 Furthermore, recent case reports suggest that CK20 may be useful to differentiate metastatic gastric cancer from primary cutaneous tumors. 5,6 Although Qureshi et al evaluated the diagnostic utility of CK20 in distinguishing primary adnexal neoplasms from metastatic carcinomas, metastatic gastric cancers were not included in the assessment. 7 In the present study, we studied the expression of a1,4-GlcNAc-capped O-glycans and CK20 immunohistochemically in cutaneous metastases of gastric cancer, primary sweat gland carcinoma and cutaneous metastases of other origin using HIK1083 antibody and CK20-specific Ks 20.8 antibody.…”

mentioning

confidence: 99%

Usefulness of Monoclonal Antibody HIK1083 Specific for Gastric O-glycan in Differentiating Cutaneous Metastasis of Gastric Cancer From Primary Sweat Gland Carcinoma

Iijima

Nakayama²,

Nishizawa³

et al. 2007

The American Journal of Dermatopathology

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Distinguishing cutaneous metastasis of gastric cancer from primary sweat gland carcinoma can be problematic in some cases, especially with a single lesion. Previously we showed that a monoclonal antibody HIK1083 directed to alpha1,4-GlcNAc-capped O-glycans expressed in gastric gland mucin reacts to gastric cancer cells. By contrast, it was reported that immunohistochemistry for cytokeratin 20 (CK20) may be helpful in the differential diagnosis between cutaneous metastasis of gastric cancer and primary sweat gland carcinoma. Here, we immunohistochemically examined the expression of alpha1,4-GlcNAc-capped O-glycans and CK20 in 7 primary sweat gland carcinomas, 7 cutaneous metastases of gastric cancer, and 21 cutaneous metastases of other origin including breast, lung, colorectum, prostate, thyroid and pancreas using HIK1083 and CK20-specific Ks 20.8 antibodies and then assessed the usefulness of these antibodies in distinguishing cutaneous metastases of gastric cancer from primary sweat gland carcinoma and other cutaneous metastatic tumors. Both alpha1,4-GlcNAc-capped O-glycans and CK20 were positive in 5 of 7 cases of cutaneous metastases of gastric cancer, while neither alpha1,4-GlcNAc-capped O-glycans nor CK20 were detected in any of the primary sweat gland carcinomas. By contrast, alpha1,4-GlcNAc-capped O-glycans was not detected in any of the cutaneous metastases other than that of gastric cancer, whereas CK20 was detected in cutaneous metastases of colorectal cancer (2/2), breast cancer (2/13), and lung adenocarcinoma (1/3). These findings indicate that immunohistochemistry using HIK1083 antibody is superior to immunohistochemistry for CK20 in distinguishing cutaneous metastasis of gastric cancer from primary sweat gland carcinomas and other cutaneous metastases.

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“…10 Each of these instances, however, differs from the current cases in that they were clinically noticeable. There are also prior reports of cutaneous metastases discovered in melanocytic nevi, 13,14 with one of those reports clearly documenting that the nevus had changed 13 and the other report 14 offering no comment whether the nevus was clinically considered to be unusual or changing. Interestingly, the subject of clinically occult metastasis has been the focus of a previous publication in which a patient underwent sentinel node biopsy for melanoma and was discovered to have metastatic breast carcinoma within a lymph node, 15 even though the primary neoplasm was never discovered.…”

Section: Discussionmentioning

confidence: 99%