1956
DOI: 10.1177/003693305600100803
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Gastric Biopsy in the Megaloblastic Anaemias

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1958
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Cited by 13 publications
(10 citation statements)
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“…Some authors have reported residual parietal cells in up to 32% of their cases 0-_ (Williams et al, 1958), and similar findings were noted by Markson and Davidson (1956), and Shiner and Doniach (1957). Whether these cells are functional or not is unclear, but they persist in the face of histamine-fast achlorhydria.…”
Section: Discussionmentioning
confidence: 57%
“…Some authors have reported residual parietal cells in up to 32% of their cases 0-_ (Williams et al, 1958), and similar findings were noted by Markson and Davidson (1956), and Shiner and Doniach (1957). Whether these cells are functional or not is unclear, but they persist in the face of histamine-fast achlorhydria.…”
Section: Discussionmentioning
confidence: 57%
“…Second, at the present time, it is not possible to make a definitive diagnosis of achlorhydria in an individual patient due to lack of histamine or pentagastrin to stimulate gastric acid secretion. Because almost all patients with achlorhydria associated with PA have atrophic gastritis or gastric atrophy (97), gastric biopsy might logically be considered a surrogate for gastric analysis in diagnosing achlorhydria. However, 25-30% of patients with achlorhydria not associated with PA do not have gastric atrophy (19,97).…”
Section: Discussionmentioning
confidence: 99%
“…Because almost all patients with achlorhydria associated with PA have atrophic gastritis or gastric atrophy (97), gastric biopsy might logically be considered a surrogate for gastric analysis in diagnosing achlorhydria. However, 25-30% of patients with achlorhydria not associated with PA do not have gastric atrophy (19,97). Moreover, in 23% of control subjects, gastric biopsy samples showed atrophic gastritis or gastric atrophy (97).…”
Section: Discussionmentioning
confidence: 99%
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“…The natural course of Hashimoto's disease would appear to be a progression from a diffuse thyroiditis in which round-cell infiltration predominates to a state in which fibrosis and loss of acini are the most notable features. Markson and Davidson (1956) have suggested that the gastric atrophy commonly found in pernicious anaemia may be an endresult of severe atrophic gastritis. Thus the pathological processes in these two diseases may be of similar type.…”
Section: Discussioinmentioning
confidence: 99%