Thyroid Auto-antibodies in Pernicious Anaemia

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

“…This finding is especially interesting, since also a clinical association between these organ-specific autoimmune diseases has been demonstrated, and thyroid autoantibodies occur with increased frequency in patients with pernicious anaemia (27,66). Noticeable is also the finding of an association between HLA-DR3 and B8 and Graves' disease (lo), the same subtypes being more frequently present in a group of patients with all characteristics of Hashimoto's thyroiditis except goitre (i.e.…”

Anemia perniciosa y enfermedades tiroideas autoinmunes en una población mayor de 65 años

“…Por otro lado, el 45% de los pacientes diagnosticados de AP tenían también una ATI, coincidiendo con otras publicaciones 12,13 . Casi la mitad de los pacientes con déficit de V-B12 comenzaron de forma aislada, sin macrocitosis ni anemia, confirmando los resultados ya referidos por otros autores 14,15 ; y por tanto, las alteraciones hematológicas no son útiles para el diagnóstico precoz de la AP en esta población.…”

“…En cuanto a la temporalidad, nuestros datos muestran que en las mujeres el riesgo de que la AP preceda a las ATI es 6 veces mayor que en los hombres, lo que podría derivar en la recomendación de solicitar anticuerpos antitiroideos en este grupo poblacional de alto riesgo, recomendación ya mencionada en otros estudios 11,12 .…”

Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

“…9,11,12 In particular, atrophic body gastritis (ABG), formerly known as type A, represents a chronic, symptomless gastritis of the fundic mucosa, which often has an autoimmune pathogenesis, 12 is involved in gastric carcinogenesis, 13 and is closely related to the appearance of microcytic anemia 4,14 and PA. 8,9 To our knowledge, ABG has not yet been directly characterized in patients with AITD, and its prevalence may be substantially different from that previously assessed only by indirect evidence (ie, the presence of antiparietal cell antibodies [APCAb] and/or PA). 3,[5][6][7][8]15 Furthermore, the prevalence of AITD, namely, lymphocytic thyroiditis, in its subclinical form appears to have increased during the past 10 years, probably because of the availability of more sensitive diagnostic tools. 16,17 This study, therefore, aimed to detect and characterize the presence of histologically and functionally proved ABG in patients with AITD.…”

“…1999;159:1726-1730 T HE ASSOCIATION between autoimmune thyroid disease (AITD) and various other autoimmune diseases was first suggested in the early 1960s. [1][2][3][4] Indeed, the term thyrogastric autoimmunity or disease has been used to define the prevalence of thyroid autoantibodies 3,[5][6][7] and/or overt AITD in patients with pernicious anemia (PA), 8 which, in turn, was improperly used as synonymous with atrophic gastritis. 9 More recently, the association between AITD and PA has been included in type IIIb polyglandular autoimmune disease.…”