Gastric antiulcer, antisecretory and cytoprotective properties of celery (<i>Apium graveolens</i>) in rats

Al‐Howiriny, Tawfeq A.; Alsheikh, Abdulmalik; Alqasoumi, Saleh I.; Al-Yahya, Mohammed A.; Eltahir, K; Rafatullah, Syed

doi:10.3109/13880200903280026

Cited by 46 publications

(23 citation statements)

References 43 publications

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“…31 Also, Al-Howiriny et al did not observe any toxic symptoms or mortality in IP administration of doses 250 and 500 mg/kg per day. 32 Therefore, the present work provides evidence of a hypotensive effect of celery seeds, which appears to be attributable to the action of some hydrophobic constituents, for example, NBP in this plant. However, more studies should be done to clarify the mechanisms of this effect.…”

Section: Figsupporting

confidence: 50%

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Moghadam

Imenshahidi

Mohajeri

2013

Journal of Medicinal Food

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This study investigated the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP) in normotensive and deoxycorticosterone acetate-induced hypertensive rats. The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally and their effects on BP and heart rate (HR) were evaluated in comparison with spirnolactone as a diuretic and positive control. Also, the amount of n-butylphthalide (NBP), as an antihypertensive constituent, in each extract was determined by HPLC. The results indicated that all extracts decreased BP and increased the HR in hypertensive rats, but had no effect on normotensive rats. The data showed that administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively. Also, the HPLC analysis data revealed that the content of NBP in the hexanic extract was 3.7 and 4 times greater than methanolic and aqueous-ethanolic extracts. It can be concluded that celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP and can be considered as an antihypertensive agent in chronic treatment of elevated BP.

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Section: Figsupporting

confidence: 50%

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Moghadam

Imenshahidi

Mohajeri

2013

Journal of Medicinal Food

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“…Pretreatment with an ethanol extract of the aerial parts of celery, presumably grown in Saudi Arabia, produced dose-dependent reductions in gastric lesions in rats irrespective of whether ulcers were induced by indomethacin, or gastroirritant agents (80 % ethanol, 0.2 M NaOH and 25 % NaCl) or cold restraint stress (Al-Howiriny et al 2010). This celery extract prevented the depletion in gastric wall mucus and gastric mucosal nonprotein sulfhydryl groups, as well as reducing malondialdehyde production.…”

Section: Efficacy Of Cse In Preventing Gastrointestinal Irritationmentioning

confidence: 96%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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“…It was shown by Al-Howiriny et al, at the dose of 250 and 500 mg/kg body weight, that ethanolic extract of celery showed antigastric ulcer activity against indomethacin, cytodestructive agents (80% ethanol, 0.2 M NaOH, and 25% NaCl), and cold restraint stress induced ulceration on rats. Apium graveolens extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, through its antioxidant potential [41]. In animals, bilberry decreased the incidence and severity of experimentally induced ulcers [40].…”

Section: Apium Graveolensmentioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used therapeutic drug groups used worldwide for curing an array of health problems like pain, inflammation, cardiovascular complications, and many other diseases, but they may cause different side effects including gastroduodenal disorders. So, there is a growing interest and need to search for nontoxic, antiulcer formulations from medicinal plants to treat NSAIDs induced gastric ulcer. Extensive research has reported on many natural plants like Camellia sinensis, Phyllanthus emblica, Myristica malabarica, Piper betle, Picrorhiza kurroa, and so forth, and their active constituents reduced NSAIDs induced gastric ulcer via their antioxidative as well as immunomodulatory activity. Therefore, use of herbal formulations in daily life may prevent NSAIDs induced gastric ulceration and other side effects.

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Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

Abstract: (2010) Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apiumgraveolens) in rats, Pharmaceutical Biology, 48:7,[786][787][788][789][790][791][792][793]

Cited by 46 publications

References 43 publications

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

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