Gastric antiulcer and antiinflammatory activities of Calotropis procera stem bark

Tour, Nagesh S.; Talele, Gokul S.

doi:10.1590/s0102-695x2011005000175

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…Pharmacological studies have reported antidiarrheal, antimicrobial, anti-inflammatory, acaricidal, anthelmintic, schizonticidal, insecticidal, and anticancer activities [ 81 , 82 ]. Antiulcer studies involving the investigation of C. procera extract against aspirin- and ethanol-induced ulcer models in albino rats at 200 and 400 mg/kg doses showed marked antiulcer activity in the open excised rat stomach when compared to the standard drugs [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Boakye-Yiadom

Kumadoh

Adase

et al. 2021

BioMed Research International

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Background. The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. This review, therefore, is aimed at obtaining knowledge on some Ghanaian ethnomedicinal plants used to treat peptic ulcers, their folkloric uses, their phytochemicals, and their antiulcer and related pharmacological activities as well as finding areas for prospective studies.Methods. Published peer-reviewed articles on ethnomedicinal plants used for the management of peptic ulcers in Ghana from 1967 to 2020 were sourced and used for the study. Results. In this review, 13 plants were identified which belong to 10 different families including Sapindaceae, Apocynaceae, and Bignoniaceae. The parts most often used for most preparations were the leaves (53%), followed by stem bark and roots (both having the same percentage of use of 17.6%), the whole plant (5.9%), and the rhizomes (5.9%). Azadirachta indica was the only plant that had undergone some patient studies in addition to animal studies. Conclusion. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Boakye-Yiadom

Kumadoh

Adase

et al. 2021

BioMed Research International

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“…The leaves and bark of C. procera have curative properties for ulcers and stomach aches. The anti-ulcer efficacy of C. procera extract was determined in white albino rats [ 143 ]. The extract significantly reduced the ulcer index, ulcer lesion score, leukocyte infiltration in the gastric epithelial lining, and ameliorated the congestion and necrosis.…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Ahmed

Rabbee

Roy

et al. 2021

Plants

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When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

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“…gastro-mucosal protective effect showed by chloroform extract at 400 mg/kg [35]. The antiulcerogenic potential of an extract of leaves and root was investigated and accounted a dose-dependent reduction of lesion formation [36].…”

Section: Karale and Karalementioning

confidence: 99%

A Review on Phytochemistry and Pharmacological Properties of Milkweed Family Herbs (Asclepiadaceae)

Karale¹,

Karale²

2017

Asian J Pharm Clin Res

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Calotropis procera and Gymnema sylvestre are a perennial shrub and woody climber, respectively, and belonging to the family Asclepiadaceae. They are commonly known as milkweed family herbs. The Calotropis commonly have two species, i.e., C. procera and C. gigantean. All parts of plant exude white milky latex when cut. It has been widely used in traditional medicine due to its pharmacological active compounds found in all parts of plants such as bark, roots, and leaves and especially its latex which exudes from damaged or broken stem and leaves. G. sylvestre an ayurvedic herb came to be known as "destroyer of sugar" because in ancient times Ayurveda physicians observed that chewing a few leaves of G. sylvestre suppressed the taste of sugar. It also reported to possess antidiabetic, antioxidant, and immunomodulatory, antiulcer, and anticancer potential. The gymnemic acid is the main constituent which is responsible for number of pharmacological activities. The present review assembles the data on pharmacognostic and pharmacological potential of C. procera and G. sylvestre.

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Gastric antiulcer and antiinflammatory activities of Calotropis procera stem bark

Cited by 12 publications

References 18 publications

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

A Review on Phytochemistry and Pharmacological Properties of Milkweed Family Herbs (Asclepiadaceae)

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