Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats

Kumar, Amrish; Singh, Vineet Kumar; Chaudhary, Anand Kumar

doi:10.1016/j.jep.2010.12.019

Cited by 53 publications

(27 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 Ulcers developed by ligating the pyloric end of the stomach are caused by an increase in gastric HCl secretion and/or stasis of acid, leading to auto digestion of the gastric mucosa and breakdown of the gastric mucosal barrier. 41 Parietal or oxyntic cells are the principal cells in gastric glands, which secrete gastric HCl to promote proteolytic digestion of foodstuffs, iron absorption, and killing of pathogens. 42 The three most important mediators, namely acetylcholine, gastrin, and histamine, interact with specific receptors located at the basolateral membrane of the parietal cells that stimulate gastric acid secretion.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Suleiman¹,

.²,

Mikail³

et al. 2019

TJNPR

View full text Add to dashboard Cite

Article history:preliminary evaluation of crude methanol stem-bark extract of the plant revealed potent antiulcer properties. 21 Although much progress has been made in the management of H. pylori infection in gastric ulcer due to the widespread use of antisecretory drugs and antibiotics, increasing antimicrobial resistance has posed a great threat to its eradication. 22 Furthermore, emerging causes of peptic ulcers other than H. pylori and NSAIDs are imposing diagnostic and therapeutic challenges. Therefore, the aim of this study was to investigate the anti-ulcer effects of the stem-bark fractions of K. senegalensis in rats.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Suleiman¹,

.²,

Mikail³

et al. 2019

TJNPR

View full text Add to dashboard Cite

show abstract

“…Although a number of antiulcer drugs such as antacid, H2 receptor antagonist, proton pump inhibitor, cytoprotectives, and prostaglandin analogues are available for treatment of ulcer, all these drugs have side effects and limitations[26]. Natural products are well known as a promising source for the discovery of major new pharmaceuticals.…”

Section: Discussionmentioning

confidence: 99%

“…The causes of gastric ulcer in pyloric ligation are believed to be due to increase in gastric hydrochloric acid secretion and/or stasis of acid, leading to auto digestion of the gastric mucosa and breakdown of the gastric mucosal barrier. These factors are associated with the development of upper gastrointestinal damage including lesions, ulcers and life threatening perforation and hemorrhage[26]. Administration of MEOC at different dose levels significantly decreased gastric secretions, total acidity, free acidity and increased pH of the gastric juice compared to control.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of Oxalis corniculata (whole plant) on experimentally induced gastric ulceration in Wistar rats

2012

View full text Add to dashboard Cite

The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. The extract was preliminary evaluated for acute oral toxicity test using Organisation for Economic Co-operation and Development guidelines 423. Further, it was studied for antiulcer potential at the dose levels of 125, 250 and 500 mg/kg. Ranitidine was used as a standard drug (100 mg/kg). Acid secretory parameters like gastric volume, pH, total acidity and free acidity were measured in pylorus ligation model, whereas numbers of ulcers, ulcers score and ulcer index was measured in pylorus ligated and indomethacin treated rats. Pretreatment of test extract significantly (p<0.05) decreased the gastric volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. It also showed significant (p<0.05) decrease in number of ulcers, ulcers score and ulcer index in pylorus ligated and indomethacin treated rats. Results of the study suggest that, the methanol extract of Oxalis corniculata possesses significant antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers.

show abstract

“…P < 0.05 were considered significant. [10] In vivo X-ray studies To view the in vivo gastric retention and floating behavior of the tablet, X-ray studies were performed in rabbits. Inclusion of barium sulfate in the tablet was essential to make the tablet visible in the X-ray.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

Enrichment of anti-ulcer activity of monoammonium glycerrhizin and Aloe vera gel powder through a novel drug delivery system

Ranade¹,

Ramesh²,

Ranpise³

2014

Asian J Pharm

View full text Add to dashboard Cite

U sual treatment for Helicobacter pylori-induced peptic ulcer includes a 14-day "triple therapy" of two antibiotics and a proton pump inhibitor. However, the current therapy has side-effects like stomach upset, non-compliance, incomplete absorption of drug and antibiotic resistance. To overcome these limitations, there is a need to suggest an alternative therapy. The best possible alternative is to deliver herbal constituents. The purpose of the present study was to optimize the efficacy of herbal constituents by applying the concept of a novel drug delivery system. The present investigation is designed to deliver and retain two herbal constituents in the stomach for better action against gastric ulcers. The objective was to develop a bilayer floating tablet of monoammonium glycerrhizin and Aloe vera gel powder through rational combination of excipients to give the lowest possible lag time with maximum drug release in 7 h. Formulation OF2 containing hydroxy propyl methyl cellulose E5, crospovidone and effervescent agents in the ratio 1:2 gave 98% drug release with desired floating properties. Pharmacodynamic studies in rats showed that the combination of monoammonium glycerrhizin and Aloe vera gave 99% ulcer inhibition in comparison with 51% ulcer inhibition in the group administered with monoammonium glycerrhizin alone. X-ray studies in rabbits proved the gastroretention of the tablet for more than 6 h. This suggests relevance of NDDS in delivery of herbal constituents in the treatment of gastric ulcer.

show abstract

Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats

Cited by 53 publications

References 12 publications

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Gastroprotective effect of Oxalis corniculata (whole plant) on experimentally induced gastric ulceration in Wistar rats

Enrichment of anti-ulcer activity of monoammonium glycerrhizin and Aloe vera gel powder through a novel drug delivery system

Contact Info

Product

Resources

About