Gastroprotective effect of Oxalis corniculata (whole plant) on experimentally induced gastric ulceration in Wistar rats

Sakat, S; Tupe, Preeti N.; Juvekar, Archana R.

doi:10.4103/0250-474x.102543

Cited by 18 publications

(4 citation statements)

References 21 publications

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“…Accumulation of gastric content and high acidic pH, lead to auto digestion of the gastric mucosa and breakdown of the gastric mucosal barrier cause ulcer 26 which was determined by calculating UI (ulcer index). UI in disease-control rats was greater than that of vehicle-control rats.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

IJPSR

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A peptic ulcer is an excoriated area of the stomach or intestinal mucosa caused principally by the digestive action of gastric juice or small upper intestinal secretions. A peptic ulcer is a conglomerate of heterogeneous disorders that manifests as a lesion in the lining of the gastrointestinal mucosa bathed by acid and pepsin. Peptic ulcers frequently occur along the lesser curvature of the antral end of the stomach or, more rarely, in the lower end of the esophagus, where stomach juices frequently reflux. It occurs because of an imbalance between aggressive factors (gastric acid and pepsin) and defensive factors (gastric mucus, bicarbonate, prostaglandins). The white mulberry tree (M. alba L.) is a deciduous tree originating from Asia but currently cultivated in subtropical, tropical, and moderate environments. M. alba leaves contain triterpenoid and steroidal saponin (lupeol, β-Sitosterol), bioflavonoids (rutin, moracetin, quercetin-3triglucoside and isoquercitrin), coumarins, volatile oil, alkaloids, amino acids and organic acids, rutin, quercetin. M. alba leaves have various pharmacological properties such as anti-cancer, Anti-dopaminergic, and Hepatoprotective activity. Antimicrobial activity, antioxidant activity. Due to the presence of several phytoconstituents in this plant have been used for ages in various traditional medicine systems to treat cough, tonify blood, constipation and diabetes.

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Section: Discussionmentioning

confidence: 99%

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2023

IJPSR

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“…On the other hand, the presence of flavonoids facilitates the increase in the mucosal prostaglandin levels and inhibition of histamine release thus exhibiting a protective effect of the extracts [45]. …”

Section: Discussionmentioning

confidence: 99%

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Ignatius

Narayanan

Subramanian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

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“…An orange (free acidity) or permanent pink (total acidity) color was observed. 32 The acidity is expressed in meq/l as follows: Total/free acidity=n×0.01×36.45×1000 n=volume of NaOH consumed, 0.01=normality of NaOH, 36.45=molecular weight of NaOH, and 1000=factor represents in liters.…”

Section: Titration Of the Acidity Of Gastric Juicementioning

confidence: 99%

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Belmamoun,

Ammam,

Mhamdia

et al. 2023

Ind. J. Pharm. Edu. Res

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Background: Our study evaluated the effect of Chrysanthemum coronarium L. (CC) leaves on ethanol-induced acute gastric ulcers in Wistar rats. Materials and Methods: The organic extract of CC was obtained by Soxhlet extraction with methanol and then divided into two dose groups: 250 mg/kg and 500 mg/kg. Omeprazole was used as a positive control at 20 mg/ kg. Our extract was subjected to the separation of bioactive compounds by High-Performance Liquid Chromatography (HPLC). Lethality tests (LD 50 ) were carried out using standard procedures. Gastric protection was assessed by measuring gastric juice volume, total acidity, and free acidity. Gastric mucosal damage was assessed by histopathological examination. Results: Chromatographic analysis of the Methanolic Extract of Chrysanthemum coronarium L. (MECC) identified the presence of 19 phenolic compounds, representing 46.47% of the total sample. The dominant components were o-coumaric acid (9.55%), chlorogenic acid (6%), myricetin (4.19%), and benzoic acid (2.87%). Oral LD 50 value was more than 5000 mg/kg in rat. In the present study, the methanolic extract of CC decreased total and free gastric acidity (53.80±7.038 and 17.8±2.375 respectively) for the 500 mg/kg dose and (60.40±4.490 and 24.8±1.855 respectively) for the 250 mg/kg dose. Omeprazole also decreased free and total gastric acidity (54.40±3.092 and 20±2.449 respectively), compared with the ethanol groups (19.40±2.909 and 4.4±0.678 respectively). In the histological study, we found that the gastric mucosal barrier could be significantly strengthened when the rats were pretreated with 500 mg/kg of the MECC and showed almost normal histology compared with the ethanol-ulcerated groups. Conclusion: Based on the present results, we can conclude that CC leaves could be a promising food for the protection of the gastric mucosa against ethanol-induced lesions.

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Gastroprotective effect of Oxalis corniculata (whole plant) on experimentally induced gastric ulceration in Wistar rats

Cited by 18 publications

References 21 publications

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Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

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