Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.

Álvarez, Alejandro González; Pomar, Francisco; Sevilla, María A.; Montero, María J.

doi:10.1016/s0378-8741(99)00092-6

Cited by 70 publications

(44 citation statements)

References 22 publications

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“…It is a known fact that flavonoids have a high safety margin and are free from side effects such as ulcerogenicity (Alvaraz et al, 1999). The results of the present study advocate the full exploitation of S. brevistigma as a hepatoprotective agent in the management of liver disorders after proper clinical trials.…”

Section: Resultssupporting

confidence: 60%

Phytochemical and pharmacological evaluation of the flowers of Sarcostemma brevistigma Wight

Lalitha¹,

Sethuraman²

2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYShade-dried flowers of Sarcostemma brevistigma Wight Syn (SBF) belonging to Asclepiadaceae yielded a rare flavonol glycoside viz., Quercetin 5a prenyl, 3-O-glucosyl, 7-O-(4c-p-coumaroyl) neohesperidoside which were characterized based on chemical and spectral (including 2D NMR) studies. The ethyl acetate fraction of alcoholic concentrate (test sample) of flowers of this plant (SBF) was evaluated for its hepatoprotective and inhibition of lipid peroxidation activities to investigate the scientific basis of the traditional uses. The oral administration in varying doses viz., 125 and 250 mg/kg of aqueous suspension of SBF to rats for 7 days produced significant (P < 0.01) hepatoprotective effect comparable to that of standard drug silymarin. The SBF afforded good hepatoprotection against CCl 4 induced elevation levels of serum marker enzymes, serum bilirubin and liver weight. The free radical scavenging effects of SBF and flavonol glycoside (SA) were assigned by Fe 2 + /ascorbate induction method (in vitro), which revealed the inhibition of lipid peroxidation. The SBF and SA showed prominent anti-lipid peroxidation activity (IC 5 0 about 180 mg/ml and 11.0 mg/ml respectively), which was comparable to standard drug curcumin (IC 5 0 about ~ 8.25 mg/ml). Thus the hepatoprotective activity of SB could be correlated to the free radical scavenging property of the flavonol glycoside.

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Section: Resultssupporting

confidence: 60%

Phytochemical and pharmacological evaluation of the flowers of Sarcostemma brevistigma Wight

Lalitha¹,

Sethuraman²

2009

Oriental Pharmacy and Experimental Medicine

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“…radiata Sch. Bip., belonging to Asteraceae family, originated from South America and can be found in almost all countries from tropical and subtropical regions [11]. And there are three common variants of this species: Bidens pilosa Linn.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

Yi¹,

Wu²,

Wu³

et al. 2016

Trop. J. Pharm Res

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“…It is possible that the inhibitory effects of extracts are due, at least partly, to the presence of terpenes (Alvarez et al, 1999;Gonzales et al, 2000). Terpenes were found to be associated with antiulcerogenic activity in other plants (Moehle et al, 1985;Mahran et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb

Subhan¹,

Hasan²,

Hossain³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe effect of alcoholic extract of Anthocephalus (A.) Cadamba Roxb. was evaluated in experimental models of pain and ulcer. Hot tail flick test, hot plate test and acetic acid induced writhing test were employed for evaluating the peripheral as well as central analgesic mechanism exerted by the extracts. Gastroprotective activity was examined by HCl and ethanol induced gastric damage test. Test group received crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (6.26 ± 0.439 s) which is comparable to diclofenac sodium (6.56 ± 0.381 s) in hot tail flick method. These experimental results also followed the experimental results of hot plate test where crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (4.74 ± 0.234 s) which is comparable to diclofenac sodium (5.58 ± 0.585 s). The crude extract at 500 and 250 mg/kg showed significant reduction in acetic acid induced writhing in mice with a maximum effect of 68.026% reduction at 500 mg/kg dose which is comparable to standard diclofenac sodium (79.93%). In gastroprotective study the extract of A. Cadamba (250 and 500 mg/kg) significantly inhibited ulceration induced by both HCl and ethanol dose dependently. Results of the study suggest that the extract possesses both analgesic and gastroprotective activity on mice.

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Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.

Cited by 70 publications

References 22 publications

Phytochemical and pharmacological evaluation of the flowers of Sarcostemma brevistigma Wight

Phytochemical and pharmacological evaluation of the flowers of Sarcostemma brevistigma Wight

Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb

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